Faculty of Pharmaceutical Sciences, Teikyo University				Publication | Japanese
Laboratory of Host Defence
	Outline of Research
One of the body’s natural defense mechanisms is the ability of blood to clot and stop bleeding. In this process, platelets play a key role by forming an initial plug, which is then stabilized by a protein called fibrin. However, if this system becomes overactive, it can lead to the formation of harmful blood clots (thrombosis) that block blood flow. Recent research has shown that immune cells, in addition to platelets and clotting factors, also play a role in the development of thrombosis. 　For example, when neutrophils are activated, they release neutrophil extracellular traps (NETs), which contain DNA, histones, and enzymes. These NETs are not only important for defending against infections but are now known to contribute to blood clot formation and even cancer spread. Our laboratory focuses on the interaction between the immune system and the blood clotting system. We are studying how disruptions in this balance can lead to excessive clot formation. In particular, we are interested in how NETs and other substances released by neutrophils affect the local environment and promote clotting. Our related research includes investigations into cancer-associated thrombosis and the role of a blood protein called LRG, which changes in concentration under inflammatory conditions. We also study metabolic disorders such as obesity and diabetes, which are closely linked to chronic inflammation and clotting problems, using mouse models. In addition, we are exploring how certain food components might influence inflammation and blood clotting, with the aim of contributing to both basic understanding and practical applications in health and nutrition. Our current research projects are as follows: 1. Studies on coagulation abnormalities induced by neutrophil-derived proteases 2. Research on thrombosis triggered by cancer chemotherapeutic agents 3. Investigation into the mechanisms underlying pre-thrombotic states and the development of its sensitive detection methods 4. Functional analysis of leucine-rich α2-glycoprotein (LRG) 5. Studies on coagulation abnormalities related to drug administration 6. Exploration of dietary functional components that prevent thrombosis and development of novel functional foods 7. Identification of neutrophil-derived factors involved in cancer metastasis and progression, and elucidation of their mechanisms
	Staff
	Professor	Naoki Ohkura, Ph.D.
	Senior Assistant Professor	Riyo Morimoto-Kamata, Ph.D.
	Fellow・Graduate Student