Laboratory of Host Defence
Lab page | Japanese
Publication List (Journals)
1.
 Randomised, double-blind, parallel group comparison of Ashitaba (Angelica Keiskei) chalcone effects on visceral fat areas and waist circumference of overweight persons Norikazu Watanabe,Kenichi Inoue,Hiroyuki Hara,Miyu Midorikawa,Mitsuhiro Ohta Naoki Ohkura International Journal of Food Sciences and Nutrition Published online: 01 Apr 2024
2.
 Antithrombotic Natural Products That Inhibit Plasminogen Activator Inhibitor 1 (PAI-1) Naoki Ohkura, Riyo Morimoto-Kamata BPB Reports 7(2) 51-55 (2024)
3.
 Supplementation with Ashitaba (Angelica keiskei) Yellow Stem Exudate Prevents Aging-Induced Thrombotic Tendencies and Systemic Inflammation Without Affecting Body Weight Gain in Mice Naoki Ohkura, Riyo Morimoto-Kamata, Katsutaka Oishi, Sayaka Higo-Yamamoto, Aya Fujinami, Ken-ichi Inoue, Mitsuhiro Ohta Journal of Medicinal Food 26(11) 843-848 (2023)
4.
 Hypofibrinolytic phenotype in Tsumura Suzuki Obese Diabetes (TSOD) mice unrelated to hyperglycemia Naoki Ohkura, Riyo Morimoto-Kamata, Yuichi Kamikubo, Yoshihisa Takahashi, Katsutaka Oishi Drug Discoveries and Therapeutics 17(5) 346-350 (2023)
5.
 A ketogenic diet containing medium-chain triglycerides reduces REM sleep duration without significant influence on mouse circadian phenotypes Haotong Zhuang, Yuri Fujikura, Naoki Ohkura, Sayaka Higo-Yamamoto, Taiga Mishima, Katsutaka Oishi Food Research International 169 112852-112852 (2023)
6.
 Age-dependent sex difference of non-alcoholic fatty liver disease in TSOD and db/db mice.; Dungubat E, Kusano H, Mori I, Tawara H, Sutoh M, Ohkura N, Takanashi M, Kuroda M, Harada N, Udo E, Souda M, Furusato B, Fukusato T, Takahashi Y.; PLoS One, 17(12):e0278580 (2022)
7.
 Nobiletin and 3'-Demethyl Nobiletin Activate Brown Adipocytes upon β-Adrenergic Stimulation.; Kihara-Negishi F, Ohkura N, Takahashi Y, Fujita T, Nakamura Y, Maruyama K, Oshitari T, Yamaguchi S.; Biological & Pharmaceutical Bulletin, 45(4):528-533 (2022)
8.
 Extracellular Vesicles Derived from 3T3-L1 Adipocytes Enhance Procoagulant Activity.; Nakatani E, Naito Y, Ishibashi K, Ohkura N, Atsumi GI.; Biological & Pharmaceutical Bulletin, 45(2):178-183 (2022)
9.
 Potential applications of Chinese herbal medicines with hemostatic properties.; Ohkura N.; Drug Discoveries & Therapeutics, 16(3):112-117 (2022)
10.
 Cathepsin G-Induced Cell Aggregation of Breast Cancer MCF-7 Decreases Doxorubicin Sensitivity in a Hypoxia-Inducible Factor-Independent Mechanism.; Morimoto-Kamata R, Matsuki S, Ohkura N, Yui S.; Biological & Pharmaceutical Bulletin, 45(12):1772-1783 (2022)
11.
 Angelica keiskei (Ashitaba) has potential as an antithrombotic health food;Ohkura N, Taniguchi M, Oishi K, Inoue K, Ohta M.; Food Research, 6 (2) 18-24 (2021)
12.
 Screening natural compounds derived from crude drugs that suppress plasminogen activator inhibitor 1 (PAI-1) production by vascular endothelial cells: Inhibitors of PAI-1 production as antithrombotic agents; Ohkura N., Atsumi G.; Journal of Japan Mibyou Association, 27(1): 14 - 18 (2021)
13.
 Comparison of male and female learning effects of chest compressions using a real-time feedback device; Maruyama K, Takeuchi Y, Kaneko I, Kihara-Negishi F, Ohkura N, Akiyama N, Sakamoto T; Sosei, 39(1): 1 - 5 (2020)
14.
 Possible antithrombotic properties of propolis; Ohkura N, Maruyama K, Kihara-Negishi F.; Journal of Apitherapy, 7(1): 1?9 (2020)
15.
 Analysis of Basic Life Support Training Provided to Pharmacy Students Using Feedback Device;Maruyama K, Takeuchi Y, Ohkura N, Kihara-Negishi F, Akiyama N, Kaneko I.; Yakugaku Zasshi, 140(6): 819?825, (2020)
16.
 Cathepsin G-Induced Insulin-Like Growth Factor (IGF) Elevation in MCF-7 Medium Is Caused by Proteolysis of IGF Binding Protein (IGFBP)-2 but Not of IGF-1; Morimoto-Kamata R, Tsuji D, Yui S.; Biological & pharmaceutical bulletin, 43(11): 1678?1686 (2020)
17.
 Ashitaba (Angelica keiskei) Exerts Possible Beneficial Effects on Metabolic Syndrome; Ohkura N, Atsumi G, Uehara S, Ohta M, Taniguchi M.; OBM Integrative and Complementary Medicine, 4(1): (2019)
18.
 Ashitaba (Angelica Keiskei) Exudate Prevents Increases in Plasminogen Activator Inhibitor-1 Induced by Obesity in Tsumura Suzuki Obese Diabetic Mice; Ohta M, Fujinami A, Oishi K, Kobayashi N, Ohnishi K, Ohkura N.; Journal of Dietary Supplements, 16(3): 331-344 (2019)
19.
 Effects of fermented rice vinegar Kurozu and its sediment on inflammation-induced plasminogen activator inhibitor 1 (PAI-1) increase; Ohkura N, Kihara-Negishi F, Fujii A, Kanouchi H, Oishi K, Atsumi GI, Nagano M.; Food and Nutrition Sciences, 9(3): 235-246 (2018)
20.
 Possible antithrombotic effects of Angelica keiskei (Ashitaba); Ohkura N, Atsumi G, Ohnishi K, Baba K, Taniguchi M.; Pharmazie, 73(6): 315 - 317 (2018)
21.
 An in vitro screening study of food functions among vegetable cultivars consumed in Japan; Ohkura N, Fujita R, Kanai R, Ishibashi K, Ueda H, Atsumi GI.; American Journal of Research in Medical Sciences, 3(1): 1-6 (2018)
22.
 Positions of Hydroxyl Groups in Chrysin are Critical for Inhibiting Plasminogen Activator Inhibitor-1 Release from Human Umbilical Vein Endothelial Cells; Ohkura N, Ando K, Takata Y, Kanai S, Ishibashi K, Taniguchi M, Tatefuji T, Atsumi G.; Natural Product Communications, 12(4): 499-502 (2017)
23.
 Cinnamic acid shortens the period of the circadian clock in mice; Oishi K., Yamamoto S, Oike H, Ohkura N, Taniguchi M.; Biochemistry and Biophysics Reports, 9: 232-237 (2017)
24.
 Insulin-like growth factor-1 signaling is responsible for cathepsin G-induced aggregation of breast cancer MCF-7 cells; Morimoto-Kamata R, Yui S.; Cancer Science, 108(8):1574-1583, (2017)
25.
 Simultaneous Determination of Catechins and Caffeine in Green Tea-Based Beverages and Foods for Specified Health Uses; Maruyama K, Kihara-Negishi F, Ohkura N, Nakamura Y, Nasui M, Saito M.; Food and Nutrition Sciences, 8: 316-325 (2017)
26.
 Circadian fluctuations in circulating plasminogen activator inhibitor-1 are independent of feeding cycles in mice; Oishi K, Ohkura N, Yasumoto Y, Yamamoto S.; Chronobiology International, 34(2): 254 - 259 (2017)
27.
 Anti-platelet effects of chalcones from Angelica keiskei Koidzumi (Ashitaba) in vivo; Ohkura N, Ohnishi K, Taniguchi M, Nakayama A, Usuba Y, Fujita M, Fujii A, Ishibashi K, Baba K, Atsumi G.; Pharmazie, 71(11): 651-654 (2016)
28.
 Effects of a diet containing Brazilian propolis on lipopolysaccharideinduced increases in plasma plasminogen activator inhibitor-1 levels in mice; Ohkura N, Oishi K, Kihara-Negishi F, Atsumi G, Tatefuji T.; Journal of Intercultural Ethnopharmacology, 5(4): 439 -443 (2016)
29.
 Blood coagulation and metabolic profiles in middle-aged male and female ob/ob mice; Ohkura N, Oishi K, Atsumi G.; Blood Coagulation & Fibrinolysis, 26(5): 522 - 526 (2015)
30.
 Inhibition of plasminogen activator inhibitor-1 release from human endothelial cells by Angelica keiskei Koidzumi (Ashitaba) chalcones is structure-dependent; Ohkura N, Oiwa H, Ohnishi K, Taniguchi M, Baba K, Atsumi G.; Journal of Intercultural Ethnopharmacology, 4(4): 355?357 (2015)
31.
 Screening for hemostatic activities of popular Chinese medicinal herbs in vitro; Ohkura N, Yokouchi H, Mimura M, Nakamura R, Atsumi G.; Journal of Intercultural Ethnopharmacology, 4: 19?23 (2015)
32.
 Neutrophil cathepsin G, but not elastase, induces aggregation of MCF-7 mammary carcinoma cells by a protease activity-dependent cell-oriented mechanism; Yui, S., Osawa, Y., Ichisugi, T., Morimoto-Kamata, R.; Mediators Inflammation, Article ID 971409, (2014)
33.
 Retinoic Acid-Induced Epidermal Transdifferentiation in Skin; Akimoto Y, Miyaji M, Morimoto-Kamata R, Kosaka Y, Obinata A.; Journal of Developmental Biology, 2(3): 158 -173 (2014)
34.
 Lipopolysaccharide-induced plasma PAI-1 increase does not correlate with PAI-1 synthesised de novo in the liver; Ohkura N, Oishi K, Nakakuki Y, Miura M, Atsumi G.; Thrombosis Research, 132(3): 398 - 399 (2013)
35.
 Acidic Sialidase Activity Is Aberrant in Obese and Diabetic Mice; Natori Y, Ohkura N, Nasui M, Atsumi G, Kihara-Negishi F.; Biological & Pharmaceutical Bulletin, 36(6): 1027 -1031 (2013)
36.
 The molecular clock regulates circadian transcription of tissue factor gene; Oishi K, Koyanagi S, Ohkura N.; Biochemical and Biophysical Research Communications, 431(2): 332?335 (2013)
37.
 Chronic circadian clock disruption induces expression of the cardiovascular risk factor plasminogen activator inhibitor-1 in mice;Oishi, N., Ohkura, N.; Blood Coagulation & Fibrinolysis, 24(1): 106 -108 (2013)
38.
 Cathepsin G induces cell aggregation of human breast cancer MCF-7 cells via a 2-StepMechanism: catalytic site-independent binding to the cell surface and enzymatic activity-dependent induction of the cell aggregation; Morimoto-Kamata R, Mizoguchi S, Ichisugi T, Yui S.; Mediators Inflammation, Article ID 456462 (2012)
39.
 Associations between plasma PAI-1 concentrations and its expressions in various organs in obese model mice; Ohkura N, Shirakura M, Nakatani E, Oishi K, Atsumi G.; Thrombosis Research, 130(6): E301 - E304 (2012)
40.
 Pollen Typhae is a rapid hemostyptic; Ohkura, N., Tauchi, C., Nakayama, A., Atsumi G.; Blood Coagulation & Fibrinolysis, 23(3): 254-255 (2012)
41.
 Propolis and its constituent chrysin inhibit plasminogen activator inhibitor 1 production induced by tumour necrosis factor- alpha and lipopolysaccharide; Ohkura N, Takata Y, Ando K, Kanai S, Watanabe M, Nohira T, Atsumi G.; Journal of Apicultural Research, 51(2): 179 ? 184 (2012)
42.
 Experimental study on the hemostatc activity of Pollen Typhae: a traditional folk medicine used by external and oral application;Ohkura N, Tamura K, Tanaka A, Matsuda, J., Atsumi, G.; Blood coagulation & fibrinolysis, 22(8): 631 - 636 (2011)
43.
 Circadian mRNA expression of coagulation and fibrinolytic factors is organ-dependently disrupted in aged mice; Oishi K, Koyanagi S, Ohkura N.; Experimental Gerontology, 46(12): 994 ? 999 (2011)
44.
 PPARγ activation induces acute PAI-1 gene expression in the liver but not in adipose tissues of diabetic model mice; Oishi K, Tomita T, Itoh N, Ohkura N.; Thrombosis research, 128(5): E81 ? E85 (2011)
45.
 Xanthoangelols isolated from Angelica keiskei inhibit inflammatory-induced plasminogen activator inhibitor 1 (PAI-1) production;Ohkura N, Nakakuki Y, Taniguchi M, Kanai S, Nakayama A, Ohnishi K, Sakata T, Nohira T, Matsuda J, Baba K, Atsumi G.; BioFactors, 37(6): 455 ? 461 (2011)
46.
 Overexpression of Hematopoietically Expressed Homeoprotein Induces Nonapoptotic Cell Death in Mouse Prechondrogenic ATDC5 Cells; Morimoto R, Obinata A.; Biological & Pharmaceutical Bulletin, 34(10): 1589 - 1595 (2011)
47.
 Functional Characterization of Rat Plasma Membrane Monoamine Transporter in the Blood-Brain and Blood-Cerebrospinal Fluid Barriers; Okura T, Kato S, Takano Y, Sato T, Yamashita A, Morimoto R, Ohtsuki S, Terasaki T, Deguchi Y.; Journal of harmaceutical Sciences, 100(9): 3924 - 3938 (2011)
48.
 Homeoprotein Hex is expressed in mouse developing chondrocytes; Morimoto R, Yamamoto A, Akimoto Y, Obinata A.; Journal of Biochemistry, 150(1): 61 - 71 (2011)
49.
 Tgm2/Gh, Gbx1 and TGF-beta are involved in retinoic acid-induced transdifferentiation from epidermis to mucosal epithelium; Obinata A, Osakabe K, Yamaguchi M, Morimoto R, Akimoto Y.; The International Journal of Developmental Biology, 55(10?12): 933 - 943 (2011)
50.
 PPARα deficiency augments a ketogenic diet-induced circadian PAI-1 expression possibly through PPARγ activation in the liver; Oishi K, Uchida D, Ohkura N, Horie S.; Biochemical and Biophysical Research Communications, 401(2): 313 ? 318 (2010)
51.
 Strain- and Tissue-Dependent Induction of Plasminogen Activator Inhibitor-1 Gene Expression in Fasted Mice; Oishi K, Ohkura N.; Biological & Pharmaceutical Bulletin, 33(3): 530 - 531 (2010)
52.
 Up-regulation of the Expression of Leucine-rich α2-glycoprotein in Hepatocytes by the Mediators of Acute-phase Response;Shirai R, Hirano H, Ohkura N, Ikeda K, Inoue S.; Bulletin of Osaka University of Pharmaceutical Sciences, 4: 85 -92 (2010)
53.
 Cathepsin G, a Neutrophil Protease, Induces Compact Cell-Cell Adhesion in MCF-7 Human Breast Cancer Cells; Kudo K, Kigoshi H, Hagiwara T, Takino T, Yamazaki M, Yui S.: Mediators of Inflammation, Article ID 850940 (2009)
54.
 Ketogenic Diet Disrupts the Circadian Clock and Increases Hypofibrinolytic Risk by Inducing Expression of Plasminogen Activator Inhibitor-1; Oishi K, Uchida D, Ohkura N, Doi R, Ishida N, Kadota K, Horie S.; Arteriosclerosis Thrombosis and Vascular Biology, 29(10): 1571-1577 (2009)
55.
 Up-regulation of the expression of leucine-rich α2-glycoprotein in hepatocytes by the mediators of acute-phase response;Shirai R, Hirano F, Ohkura N, Ikeda K, Inoue S.; Biochemical and Biophysical Research Communications, 382(4): 776 - 779 (2009)
56.
 PERIOD2 is a circadian negative regulator of PAI-1 gene expression in mice;Oishi K, Miyazaki K, Uchida D, Ohkura N, Wakabayashi M, Doi R, Matsuda J, Ishida N.; Journal of Molecular and Cellular Cardiology, 46(4): 545 - 552 (2009)
57.
 CLOCK regulates circadian platelet activity; Ohkura N, Oishi K, Sudo T, Hayashi H, Shikata K, Ishida N, Matsuda J, Horie S.; Thrombosis Research, 123(3): 523 - 527 (2009)
58.
 Subunit structure and inhibition specificity of alpha-type phospholipase A(2) inhibitor from Protobothrops flavoviridis; Shimada A. Ohkura N, Hayashi K, Samejima Y, Omori-Satoh T, Inoue S, Ikeda K.; Toxicon, 51(5): 787 - 796 (2008)
59.
 Sole existence of antithrombin antibody in patients with systemic lupus erythematosus showing tendency of its antigenic determinants directing against exosite II (antithrombin/heparin binding site) of thrombin; Matsuda J, Matsuyama A, Atsumi G, Ohkura N.; Blood Coagulation & Fibrinolysis, 19(1): 66 -69 (2008)
60.
 CLOCK regulates the circadian rhythm of kaolin-induced writhing behavior in mice; Oishi K, Ohkura N, Sei H, Matsuda J, Ishida N.; Neuroreport, 18(18): 1925 -1928 (2007)
61.
 Food deprivation induces adipose plasminogen activator inhibitor-1 (PAI-1) expression without accumulation of plasma PAI-1 in genetically obese and diabetic db/db mice; Oishi K, Ohkura N, Matsuda J, Ishida N.; Thrombosis and Haemostasis, 98(4): 864 - 870 (2007)
62.
 Circadian variations in coagulation and fibrinolytic factors among four different strains of mice;Ohkura N, Oishi K, Sakata T, Kadota K, Kasamatsu M, Fukushima N, Kurata A, Tamai Y, Shirai H, Atsumi G, Ishida N, Matsuda J, Horie S.; Chronobiology International, 24(4): 651 ? 669 (2007)
63.
 Comparative study of circadian variation in numbers of peripheral blood cells among mouse strains: Unique feature of C3H/HeN mice; Ohkura N, Oishi K, Sekine Y, Atsumi G, Ishida N. Matsuda J, Horie S.; Biological & Pharmaceutical Bulletin, 30(6): 1177 - 1180 (2007)
64.
 Circadian variations in coagulation and fibrinolytic factors among four different strains of mice; Ohkura N, Oishi K, Sakata T, Kadota K, Kasamatsu M, Fukushima N, Kurata A, Tamai Y, Shira H, Atsumi G, Ishida N, Matsuda J, Horie S.; Chronobiology International, 24(4): 651 - 669 (2007)
65.
 Induction of multicellular 3-D spheroids of MCF-7 breast carcinoma cells by neutrophil-derived cathepsin G and elastase; Yui S, Tomita K, Kudo T, Ando S, Yamazaki M.; Cancer Science, 96(9): 560 -570 (2006)
66.
 Circadian clock molecules CLOCK and CRYs modulate fibrinolytic activity by regulating the PAI-1 gene expression;Ohkura N, Oishi K, Fukushima N, Kasamatsu M, Atsumi G, Ishida N, Horie S, Matsuda J.; Journal of Thrombosis and Haemostasis, 4(11): 2478 - 2485 (2006)
67.
 Clock mutation affects circadian regulation of circulating blood cells; Oishi K, Ohkura N, Kadota K, Kasamatsu M, Shibusawa K, Matsuda J, Machida K, Horie S, Ishida N.; Journal of Circadian Rhythms, 4: 13 (2006)
68.
 CLOCK is involved in obesity-induced disordered fibrinolysis in ob/ob mice by regulating PAI-1 gene expression; Oishi K, Ohkura N, Wakabayashi M, Shirai H, Sato K, Matsuda J, Atsumi G, Ishida N.; Journal of Thrombosis and Haemostasis, 4(8): 1774 - 1780 (2006)
69.
 Adrenal gland-dependent augmentation of plasminogen activator inhibitor-1 expression in streptozotocin-induced diabetic mice;Oishi K, Ohkura N, Ishida N.; Journal of Thrombosis and Haemostasis, 4(7): 1566 - 1574 (2006)
70.
 Extended light exposure suppresses nocturnal increases in cytotoxic activity of splenic natural killer cells in rats; Oishi K, Shibusawa K, Kakazu H, Kuriyama T, N Ohkura, K Machida.; Biological Rhythm Research, 37(1): 29 - 35 (2006)
71.
 Secretion of L-glutamate from osteoclasts through transcytosis;Morimoto R, Uehara S, Yatsushiro S, Juge N, Hua Z, Senoh S, Echigo N, Hayashi M, Mizoguchi T, Ninomiya T, Udagawa N, Omote H, Yamamoto A, Edwards RH, Moriyama Y.; EMBO Journal, 25(18): 4175 - 4186 (2006)
72.
 Involvement of circadian clock gene Clock in diabetes-induced circadian augmentation of plasminogen activator inhibitor-1 (PAI-1) expression in the mouse heart; Oishi K, Ohkura N, Amagai N, Ishida N.; FEBS Letters, 579(17): 3555 - 3559 (2005)
73.
 Genome-wide expression analysis reveals 100 adrenal gland-dependent circadian genes in the mouse liver; Oishi K, Amagai N, Shirai H, Kadota K, Ohkura N, Ishida N.; DNA Research, 12(3): 191 - 202 (2005)
74.
 Potential of free-form TFPI and PAI-1 to be useful markers of early atherosclerosis in a Japanese general population (the Suita Study): association with the intimal-medial thickness of carotid arteries; Sakata T, Mannami S, Baba Y, Kokubo K, Kario A, Okamoto K, Kumeda Ohkura N., Katayama Y, Miyata, T., Tomoike, H., Kato, H.; Atherosclerosis, 176(2): 355 ? 360 (2004)
75.
 Oxidized phospholipids in oxidized low-density lipoprotein reduce the activity of tissue factor pathway inhibitor through association with its carboxy-terminal region;Ohkura N, Hiraishi S, Itabe H, Hamuro T, Kamikubo Y, Takano T, Matsuda J, Horie S.; Antioxidants & Redox Signaling, 6(4): 705 - 712 (2004)
76.
 Tissue-specific augmentation of circadian PAI-1 expression in mice with streptozotocin-induced diabetes; Oishi K, Ohkura N, Kasamatsu M, Fukushima N, Shirai H, Matsuda J, Horie S, Ishida N.; Thrombosis Research, 114(2): 129 - 135 (2004)
77.
 Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes; K Oishi, K Miyazaki, K Kadota, R Kikuno, T Nagase, G Atsumi, N Ohkura, T Azama, M Mesaki, S Yukimasa, H Kobayashi, C Iitaka, T Umehara, M Horikoshi, T Kudo, Y Shimizu, M Yano, M Monden, K Machida, J Matsuda, S Horie, T Todo, N Ishida.; Journal of Biological Chemistry, 278(42): 41519 - 41527 (2003)