Laboratory of Host Defence
Lab page | Japanese
Publication List (Journals)
1.
 A ketogenic diet containing medium-chain triglycerides reduces REM sleep duration without significant influence on mouse circadian phenotypes.; Zhuang H, Fujikura Y, Ohkura N, Higo-Yamamoto S, Taiga Mishima T, Oishi K.; Food Research International, in press (2023)
2.
 Age-dependent sex difference of non-alcoholic fatty liver disease in TSOD and db/db mice.; Dungubat E, Kusano H, Mori I, Tawara H, Sutoh M, Ohkura N, Takanashi M, Kuroda M, Harada N, Udo E, Souda M, Furusato B, Fukusato T, Takahashi Y.; PLoS One, 17(12):e0278580 (2022)
3.
 Nobiletin and 3'-Demethyl Nobiletin Activate Brown Adipocytes upon β-Adrenergic Stimulation.; Kihara-Negishi F, Ohkura N, Takahashi Y, Fujita T, Nakamura Y, Maruyama K, Oshitari T, Yamaguchi S.; Biological & Pharmaceutical Bulletin, 45(4):528-533 (2022)
4.
 Extracellular Vesicles Derived from 3T3-L1 Adipocytes Enhance Procoagulant Activity.; Nakatani E, Naito Y, Ishibashi K, Ohkura N, Atsumi GI.; Biological & Pharmaceutical Bulletin, 45(2):178-183 (2022)
5.
 Potential applications of Chinese herbal medicines with hemostatic properties.; Ohkura N.; Drug Discoveries & Therapeutics, 16(3):112-117 (2022)
6.
 Cathepsin G-Induced Cell Aggregation of Breast Cancer MCF-7 Decreases Doxorubicin Sensitivity in a Hypoxia-Inducible Factor-Independent Mechanism.; Morimoto-Kamata R, Matsuki S, Ohkura N, Yui S.; Biological & Pharmaceutical Bulletin, 45(12):1772-1783 (2022)
7.
 Angelica keiskei (Ashitaba) has potential as an antithrombotic health food;Ohkura N, Taniguchi M, Oishi K, Inoue K, Ohta M.; Food Research, in press (2021)
8.
 Screening natural compounds derived from crude drugs that suppress plasminogen activator inhibitor 1 (PAI-1) production by vascular endothelial cells: Inhibitors of PAI-1 production as antithrombotic agents; Ohkura N., Atsumi G.; Journal of Japan Mibyou Association, 27(1): 14 - 18 (2021)
9.
 Comparison of male and female learning effects of chest compressions using a real-time feedback device; Maruyama K, Takeuchi Y, Kaneko I, Kihara-Negishi F, Ohkura N, Akiyama N, Sakamoto T; Sosei, 39(1): 1 - 5 (2020)
10.
 Possible antithrombotic properties of propolis; Ohkura N, Maruyama K, Kihara-Negishi F.; Journal of Apitherapy, 7(1): 1?9 (2020)
11.
 Analysis of Basic Life Support Training Provided to Pharmacy Students Using Feedback Device;Maruyama K, Takeuchi Y, Ohkura N, Kihara-Negishi F, Akiyama N, Kaneko I.; Yakugaku Zasshi, 140(6): 819?825, (2020)
12.
 Cathepsin G-Induced Insulin-Like Growth Factor (IGF) Elevation in MCF-7 Medium Is Caused by Proteolysis of IGF Binding Protein (IGFBP)-2 but Not of IGF-1; Morimoto-Kamata R, Tsuji D, Yui S.; Biological & pharmaceutical bulletin, 43(11): 1678?1686 (2020)
13.
 Ashitaba (Angelica keiskei) Exerts Possible Beneficial Effects on Metabolic Syndrome; Ohkura N, Atsumi G, Uehara S, Ohta M, Taniguchi M.; OBM Integrative and Complementary Medicine, 4(1): (2019)
14.
 Ashitaba (Angelica Keiskei) Exudate Prevents Increases in Plasminogen Activator Inhibitor-1 Induced by Obesity in Tsumura Suzuki Obese Diabetic Mice; Ohta M, Fujinami A, Oishi K, Kobayashi N, Ohnishi K, Ohkura N.; Journal of Dietary Supplements, 16(3): 331-344 (2019)
15.
 Effects of fermented rice vinegar Kurozu and its sediment on inflammation-induced plasminogen activator inhibitor 1 (PAI-1) increase; Ohkura N, Kihara-Negishi F, Fujii A, Kanouchi H, Oishi K, Atsumi GI, Nagano M.; Food and Nutrition Sciences, 9(3): 235-246 (2018)
16.
 Possible antithrombotic effects of Angelica keiskei (Ashitaba); Ohkura N, Atsumi G, Ohnishi K, Baba K, Taniguchi M.; Pharmazie, 73(6): 315 - 317 (2018)
17.
 An in vitro screening study of food functions among vegetable cultivars consumed in Japan; Ohkura N, Fujita R, Kanai R, Ishibashi K, Ueda H, Atsumi GI.; American Journal of Research in Medical Sciences, 3(1): 1-6 (2018)
18.
 Positions of Hydroxyl Groups in Chrysin are Critical for Inhibiting Plasminogen Activator Inhibitor-1 Release from Human Umbilical Vein Endothelial Cells; Ohkura N, Ando K, Takata Y, Kanai S, Ishibashi K, Taniguchi M, Tatefuji T, Atsumi G.; Natural Product Communications, 12(4): 499-502 (2017)
19.
 Cinnamic acid shortens the period of the circadian clock in mice; Oishi K., Yamamoto S, Oike H, Ohkura N, Taniguchi M.; Biochemistry and Biophysics Reports, 9: 232-237 (2017)
20.
 Insulin-like growth factor-1 signaling is responsible for cathepsin G-induced aggregation of breast cancer MCF-7 cells; Morimoto-Kamata R, Yui S.; Cancer Science, 108(8):1574-1583, (2017)
21.
 Simultaneous Determination of Catechins and Caffeine in Green Tea-Based Beverages and Foods for Specified Health Uses; Maruyama K, Kihara-Negishi F, Ohkura N, Nakamura Y, Nasui M, Saito M.; Food and Nutrition Sciences, 8: 316-325 (2017)
22.
 Circadian fluctuations in circulating plasminogen activator inhibitor-1 are independent of feeding cycles in mice; Oishi K, Ohkura N, Yasumoto Y, Yamamoto S.; Chronobiology International, 34(2): 254 - 259 (2017)
23.
 Anti-platelet effects of chalcones from Angelica keiskei Koidzumi (Ashitaba) in vivo; Ohkura N, Ohnishi K, Taniguchi M, Nakayama A, Usuba Y, Fujita M, Fujii A, Ishibashi K, Baba K, Atsumi G.; Pharmazie, 71(11): 651-654 (2016)
24.
 Effects of a diet containing Brazilian propolis on lipopolysaccharideinduced increases in plasma plasminogen activator inhibitor-1 levels in mice; Ohkura N, Oishi K, Kihara-Negishi F, Atsumi G, Tatefuji T.; Journal of Intercultural Ethnopharmacology, 5(4): 439 -443 (2016)
25.
 Blood coagulation and metabolic profiles in middle-aged male and female ob/ob mice; Ohkura N, Oishi K, Atsumi G.; Blood Coagulation & Fibrinolysis, 26(5): 522 - 526 (2015)
26.
 Inhibition of plasminogen activator inhibitor-1 release from human endothelial cells by Angelica keiskei Koidzumi (Ashitaba) chalcones is structure-dependent; Ohkura N, Oiwa H, Ohnishi K, Taniguchi M, Baba K, Atsumi G.; Journal of Intercultural Ethnopharmacology, 4(4): 355?357 (2015)
27.
 Screening for hemostatic activities of popular Chinese medicinal herbs in vitro; Ohkura N, Yokouchi H, Mimura M, Nakamura R, Atsumi G.; Journal of Intercultural Ethnopharmacology, 4: 19?23 (2015)
28.
 Neutrophil cathepsin G, but not elastase, induces aggregation of MCF-7 mammary carcinoma cells by a protease activity-dependent cell-oriented mechanism; Yui, S., Osawa, Y., Ichisugi, T., Morimoto-Kamata, R.; Mediators Inflammation, Article ID 971409, (2014)
29.
 Retinoic Acid-Induced Epidermal Transdifferentiation in Skin; Akimoto Y, Miyaji M, Morimoto-Kamata R, Kosaka Y, Obinata A.; Journal of Developmental Biology, 2(3): 158 -173 (2014)
30.
 Lipopolysaccharide-induced plasma PAI-1 increase does not correlate with PAI-1 synthesised de novo in the liver; Ohkura N, Oishi K, Nakakuki Y, Miura M, Atsumi G.; Thrombosis Research, 132(3): 398 - 399 (2013)
31.
 Acidic Sialidase Activity Is Aberrant in Obese and Diabetic Mice; Natori Y, Ohkura N, Nasui M, Atsumi G, Kihara-Negishi F.; Biological & Pharmaceutical Bulletin, 36(6): 1027 -1031 (2013)
32.
 The molecular clock regulates circadian transcription of tissue factor gene; Oishi K, Koyanagi S, Ohkura N.; Biochemical and Biophysical Research Communications, 431(2): 332?335 (2013)
33.
 Chronic circadian clock disruption induces expression of the cardiovascular risk factor plasminogen activator inhibitor-1 in mice;Oishi, N., Ohkura, N.; Blood Coagulation & Fibrinolysis, 24(1): 106 -108 (2013)
34.
 Cathepsin G induces cell aggregation of human breast cancer MCF-7 cells via a 2-StepMechanism: catalytic site-independent binding to the cell surface and enzymatic activity-dependent induction of the cell aggregation; Morimoto-Kamata R, Mizoguchi S, Ichisugi T, Yui S.; Mediators Inflammation, Article ID 456462 (2012)
35.
 Associations between plasma PAI-1 concentrations and its expressions in various organs in obese model mice; Ohkura N, Shirakura M, Nakatani E, Oishi K, Atsumi G.; Thrombosis Research, 130(6): E301 - E304 (2012)
36.
 Pollen Typhae is a rapid hemostyptic; Ohkura, N., Tauchi, C., Nakayama, A., Atsumi G.; Blood Coagulation & Fibrinolysis, 23(3): 254-255 (2012)
37.
 Propolis and its constituent chrysin inhibit plasminogen activator inhibitor 1 production induced by tumour necrosis factor- alpha and lipopolysaccharide; Ohkura N, Takata Y, Ando K, Kanai S, Watanabe M, Nohira T, Atsumi G.; Journal of Apicultural Research, 51(2): 179 ? 184 (2012)
38.
 Experimental study on the hemostatc activity of Pollen Typhae: a traditional folk medicine used by external and oral application;Ohkura N, Tamura K, Tanaka A, Matsuda, J., Atsumi, G.; Blood coagulation & fibrinolysis, 22(8): 631 - 636 (2011)
39.
 Circadian mRNA expression of coagulation and fibrinolytic factors is organ-dependently disrupted in aged mice; Oishi K, Koyanagi S, Ohkura N.; Experimental Gerontology, 46(12): 994 ? 999 (2011)
40.
 PPARγ activation induces acute PAI-1 gene expression in the liver but not in adipose tissues of diabetic model mice; Oishi K, Tomita T, Itoh N, Ohkura N.; Thrombosis research, 128(5): E81 ? E85 (2011)
41.
 Xanthoangelols isolated from Angelica keiskei inhibit inflammatory-induced plasminogen activator inhibitor 1 (PAI-1) production;Ohkura N, Nakakuki Y, Taniguchi M, Kanai S, Nakayama A, Ohnishi K, Sakata T, Nohira T, Matsuda J, Baba K, Atsumi G.; BioFactors, 37(6): 455 ? 461 (2011)
42.
 Overexpression of Hematopoietically Expressed Homeoprotein Induces Nonapoptotic Cell Death in Mouse Prechondrogenic ATDC5 Cells; Morimoto R, Obinata A.; Biological & Pharmaceutical Bulletin, 34(10): 1589 - 1595 (2011)
43.
 Functional Characterization of Rat Plasma Membrane Monoamine Transporter in the Blood-Brain and Blood-Cerebrospinal Fluid Barriers; Okura T, Kato S, Takano Y, Sato T, Yamashita A, Morimoto R, Ohtsuki S, Terasaki T, Deguchi Y.; Journal of harmaceutical Sciences, 100(9): 3924 - 3938 (2011)
44.
 Homeoprotein Hex is expressed in mouse developing chondrocytes; Morimoto R, Yamamoto A, Akimoto Y, Obinata A.; Journal of Biochemistry, 150(1): 61 - 71 (2011)
45.
 Tgm2/Gh, Gbx1 and TGF-beta are involved in retinoic acid-induced transdifferentiation from epidermis to mucosal epithelium; Obinata A, Osakabe K, Yamaguchi M, Morimoto R, Akimoto Y.; The International Journal of Developmental Biology, 55(10?12): 933 - 943 (2011)
46.
 PPARα deficiency augments a ketogenic diet-induced circadian PAI-1 expression possibly through PPARγ activation in the liver; Oishi K, Uchida D, Ohkura N, Horie S.; Biochemical and Biophysical Research Communications, 401(2): 313 ? 318 (2010)
47.
 Strain- and Tissue-Dependent Induction of Plasminogen Activator Inhibitor-1 Gene Expression in Fasted Mice; Oishi K, Ohkura N.; Biological & Pharmaceutical Bulletin, 33(3): 530 - 531 (2010)
48.
 Up-regulation of the Expression of Leucine-rich α2-glycoprotein in Hepatocytes by the Mediators of Acute-phase Response;Shirai R, Hirano H, Ohkura N, Ikeda K, Inoue S.; Bulletin of Osaka University of Pharmaceutical Sciences, 4: 85 -92 (2010)
49.
 Cathepsin G, a Neutrophil Protease, Induces Compact Cell-Cell Adhesion in MCF-7 Human Breast Cancer Cells; Kudo K, Kigoshi H, Hagiwara T, Takino T, Yamazaki M, Yui S.: Mediators of Inflammation, Article ID 850940 (2009)
50.
 Ketogenic Diet Disrupts the Circadian Clock and Increases Hypofibrinolytic Risk by Inducing Expression of Plasminogen Activator Inhibitor-1; Oishi K, Uchida D, Ohkura N, Doi R, Ishida N, Kadota K, Horie S.; Arteriosclerosis Thrombosis and Vascular Biology, 29(10): 1571-1577 (2009)
51.
 Up-regulation of the expression of leucine-rich α2-glycoprotein in hepatocytes by the mediators of acute-phase response;Shirai R, Hirano F, Ohkura N, Ikeda K, Inoue S.; Biochemical and Biophysical Research Communications, 382(4): 776 - 779 (2009)
52.
 PERIOD2 is a circadian negative regulator of PAI-1 gene expression in mice;Oishi K, Miyazaki K, Uchida D, Ohkura N, Wakabayashi M, Doi R, Matsuda J, Ishida N.; Journal of Molecular and Cellular Cardiology, 46(4): 545 - 552 (2009)
53.
 CLOCK regulates circadian platelet activity; Ohkura N, Oishi K, Sudo T, Hayashi H, Shikata K, Ishida N, Matsuda J, Horie S.; Thrombosis Research, 123(3): 523 - 527 (2009)
54.
 Subunit structure and inhibition specificity of alpha-type phospholipase A(2) inhibitor from Protobothrops flavoviridis; Shimada A. Ohkura N, Hayashi K, Samejima Y, Omori-Satoh T, Inoue S, Ikeda K.; Toxicon, 51(5): 787 - 796 (2008)
55.
 Sole existence of antithrombin antibody in patients with systemic lupus erythematosus showing tendency of its antigenic determinants directing against exosite II (antithrombin/heparin binding site) of thrombin; Matsuda J, Matsuyama A, Atsumi G, Ohkura N.; Blood Coagulation & Fibrinolysis, 19(1): 66 -69 (2008)
56.
 CLOCK regulates the circadian rhythm of kaolin-induced writhing behavior in mice; Oishi K, Ohkura N, Sei H, Matsuda J, Ishida N.; Neuroreport, 18(18): 1925 -1928 (2007)
57.
 Food deprivation induces adipose plasminogen activator inhibitor-1 (PAI-1) expression without accumulation of plasma PAI-1 in genetically obese and diabetic db/db mice; Oishi K, Ohkura N, Matsuda J, Ishida N.; Thrombosis and Haemostasis, 98(4): 864 - 870 (2007)
58.
 Circadian variations in coagulation and fibrinolytic factors among four different strains of mice;Ohkura N, Oishi K, Sakata T, Kadota K, Kasamatsu M, Fukushima N, Kurata A, Tamai Y, Shirai H, Atsumi G, Ishida N, Matsuda J, Horie S.; Chronobiology International, 24(4): 651 ? 669 (2007)
59.
 Comparative study of circadian variation in numbers of peripheral blood cells among mouse strains: Unique feature of C3H/HeN mice; Ohkura N, Oishi K, Sekine Y, Atsumi G, Ishida N. Matsuda J, Horie S.; Biological & Pharmaceutical Bulletin, 30(6): 1177 - 1180 (2007)
60.
 Circadian variations in coagulation and fibrinolytic factors among four different strains of mice; Ohkura N, Oishi K, Sakata T, Kadota K, Kasamatsu M, Fukushima N, Kurata A, Tamai Y, Shira H, Atsumi G, Ishida N, Matsuda J, Horie S.; Chronobiology International, 24(4): 651 - 669 (2007)
61.
 Induction of multicellular 3-D spheroids of MCF-7 breast carcinoma cells by neutrophil-derived cathepsin G and elastase; Yui S, Tomita K, Kudo T, Ando S, Yamazaki M.; Cancer Science, 96(9): 560 -570 (2006)
62.
 Circadian clock molecules CLOCK and CRYs modulate fibrinolytic activity by regulating the PAI-1 gene expression;Ohkura N, Oishi K, Fukushima N, Kasamatsu M, Atsumi G, Ishida N, Horie S, Matsuda J.; Journal of Thrombosis and Haemostasis, 4(11): 2478 - 2485 (2006)
63.
 Clock mutation affects circadian regulation of circulating blood cells; Oishi K, Ohkura N, Kadota K, Kasamatsu M, Shibusawa K, Matsuda J, Machida K, Horie S, Ishida N.; Journal of Circadian Rhythms, 4: 13 (2006)
64.
 CLOCK is involved in obesity-induced disordered fibrinolysis in ob/ob mice by regulating PAI-1 gene expression; Oishi K, Ohkura N, Wakabayashi M, Shirai H, Sato K, Matsuda J, Atsumi G, Ishida N.; Journal of Thrombosis and Haemostasis, 4(8): 1774 - 1780 (2006)
65.
 Adrenal gland-dependent augmentation of plasminogen activator inhibitor-1 expression in streptozotocin-induced diabetic mice;Oishi K, Ohkura N, Ishida N.; Journal of Thrombosis and Haemostasis, 4(7): 1566 - 1574 (2006)
66.
 Extended light exposure suppresses nocturnal increases in cytotoxic activity of splenic natural killer cells in rats; Oishi K, Shibusawa K, Kakazu H, Kuriyama T, N Ohkura, K Machida.; Biological Rhythm Research, 37(1): 29 - 35 (2006)
67.
 Secretion of L-glutamate from osteoclasts through transcytosis;Morimoto R, Uehara S, Yatsushiro S, Juge N, Hua Z, Senoh S, Echigo N, Hayashi M, Mizoguchi T, Ninomiya T, Udagawa N, Omote H, Yamamoto A, Edwards RH, Moriyama Y.; EMBO Journal, 25(18): 4175 - 4186 (2006)
68.
 Involvement of circadian clock gene Clock in diabetes-induced circadian augmentation of plasminogen activator inhibitor-1 (PAI-1) expression in the mouse heart; Oishi K, Ohkura N, Amagai N, Ishida N.; FEBS Letters, 579(17): 3555 - 3559 (2005)
69.
 Genome-wide expression analysis reveals 100 adrenal gland-dependent circadian genes in the mouse liver; Oishi K, Amagai N, Shirai H, Kadota K, Ohkura N, Ishida N.; DNA Research, 12(3): 191 - 202 (2005)
70.
 Potential of free-form TFPI and PAI-1 to be useful markers of early atherosclerosis in a Japanese general population (the Suita Study): association with the intimal-medial thickness of carotid arteries; Sakata T, Mannami S, Baba Y, Kokubo K, Kario A, Okamoto K, Kumeda Ohkura N., Katayama Y, Miyata, T., Tomoike, H., Kato, H.; Atherosclerosis, 176(2): 355 ? 360 (2004)
71.
 Oxidized phospholipids in oxidized low-density lipoprotein reduce the activity of tissue factor pathway inhibitor through association with its carboxy-terminal region;Ohkura N, Hiraishi S, Itabe H, Hamuro T, Kamikubo Y, Takano T, Matsuda J, Horie S.; Antioxidants & Redox Signaling, 6(4): 705 - 712 (2004)
72.
 Tissue-specific augmentation of circadian PAI-1 expression in mice with streptozotocin-induced diabetes; Oishi K, Ohkura N, Kasamatsu M, Fukushima N, Shirai H, Matsuda J, Horie S, Ishida N.; Thrombosis Research, 114(2): 129 - 135 (2004)
73.
 Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes; K Oishi, K Miyazaki, K Kadota, R Kikuno, T Nagase, G Atsumi, N Ohkura, T Azama, M Mesaki, S Yukimasa, H Kobayashi, C Iitaka, T Umehara, M Horikoshi, T Kudo, Y Shimizu, M Yano, M Monden, K Machida, J Matsuda, S Horie, T Todo, N Ishida.; Journal of Biological Chemistry, 278(42): 41519 - 41527 (2003)