Faculty of Pharma Sciences, Teikyo University Lab page | Japanese
Laboratory of Drug and Gene Delivery Research
Publication List (Journals)
1.
 Viability variation of T-cells under ultrasound exposure according to adhesion condition with bubbles; Kajita N., Ito Y., Watanabe S., Miyamaoto Y., Omata D., Maruyama K., Suzuki R., MasudaK.: J. Med. Ultrason, (2023) in press
2.
 Feasibility study of novel nanoparticles derived from Glycyrrhizae radix as vaccine adjuvant for cancer immunotherapy; Suzuki Y., Munakata L., Omata D., Koisumi K., Suzuki R.; Immunotherapy, 14(18), 1443-1455 (2022)
3.
 Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain; Ogawa K., Kato N., Yoshida M., Hiu T., Matsuo T., Mizukami S., Omata D., Suzuki R., Mauryama K., Mukai H., Kawakami S. J. Control. Release, 348, 34-41, (2022)
4.
 Ultrasound-directed enzyme-prodrug therapy (UDEPT) using self-immolative doxorubicin derivatives; Roemhild K., Besse HC., Wang B., Pena Q., Sun Q., Omata D., Ozbakir B., Bos C., Scheeren HW., Storm G., Metselaar JM., Yu H., Knuchel-Clarke R., Kiessling F., Moonen CTW., Deckers R., Shi Y., Lammers T. Theranostics, 12(10) 4791-4801 (2022)
5.
 Ultrasound and microbubble-mediated drug delivery and immunotherapy. Daiki Omata, Munakata Lisa, Maruyama Kazuo, Ryos Suzuki, J. Med. Ultrason. (2022) in press
6.
 Ultrasound image-guided gene delivery using three-dimensional diagnostic ultrasound and lipid-based microbubbles, Daiki Omata, Lisa Munakata, Saori Kageyama, Yuno Suzuki, Tamotsu Maruyama, Tadamitsu Shima, Takumi Chikaarashi, Naoya Kajita, Kohji Masuda, Naoto Tsuchiya, Kazuo Maruyama, Ryo Suzuki, J. Drug Target. 30(2) 200-207 (2022)
7.
 Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery, Omata Daiki, Lisa Munakata, Kazuo Maruyama, Ryo Suzuki, Biol Pharm Bull 44(10) 1391-1398 (2021)
8.
 Ternary Complexes of pDNA, Neuron-Binding Peptide, and PEGylated Polyethyleneimine for Brain Delivery with Nano-Bubbles and Ultrasound. Endo-Takahashi Y., Kurokawa R., Sato K., Takizawa N., Katagiri F., Hamano N., Suzuki R., Maruyama K., Nomizu M., Takagi N., Negishi Y., Pharmaceutics. 13(7):1003 (2021)
9.
 Development of combination adjuvant for efficient T cell and antibody response induction against protein antigen. Haseda Y., Munakata L., Kimura C., Kinugasa-Katayama Y., Mori Y., Suzuki R., Aoshi T., PLoS One. 16(8):e0254628 (2021)
10.
 HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells; Kashio T., Shirakura K., Kinoshita M., Morita M., Ishiba R., Muraoka K., Kanbara T., Tanaka M., Funatsu R., Hino N., Koyama S., Suzuki R., Yoshioka Y., Aoshi T., Doi T., Okada Y.; Tissue Barriers, (2021) 9(3), 1911195, (2021)
11.
 Lipid bubbles combined with low-intensity ultrasound enhance the intratumoral accumulation and antitumor effect of pegylated liposomal doxorubicin in vivo; Yokoe I., Omata D., Unga J., Suzuki R., Mauryama K., Okamoto Y., Osaki T.; Drug. Deliv., 28(1), 530-541 (2021)
12.
 Enhanced antitumor activity of combined lipid bubble ultrasound and anticancer drugs in gynecological cervical cancers; Yamaguchi K., Matumoto Y., Suzuki R., Nishida H., Omata D., Inaba H., Kukita A., Tanikawa M., Sone K., Oda K., Osuga Y., Maruyama K., Fujii T.; Cancer Sci., (2021) ,112(6), 2493-2503 (2021)
13.
 Inhibition of miR-96-5p in the mouse brain increases glutathione leveles by altering NOVA1 expression; Kinoshita C., Kikuchi-Utsumi K., Aoyama K., Suzuki R., Okamoto Y., Matsumura N., Omata D., Maruyama K., Nakaki T.; Commun. Biol., 4(1), 182 (2021)
14.
 Effect of lipid shell composition in DSPG-based microbubbles on blood flow imaging with ultrasonography; Maruyama T., Sugii M., Omata D., Unga J., Shima T., Munakata L., Kageyama S., Hagiwara F., Suzuki Y., Maruyama K., Suzuki R.; Int J. Pharm., 590, 119886 (2020)
15.
 "A pilot study on efficacy of lipid bubbles for theranostics in dogs with tumors; Yokoe I., Murahata Y., Harada K., Sunden Y., Omata D., Unga J., Suzuki R., Mruyama K., Okamoto Y., Osaki T.; Cancers, 12(9), 2423 (2020)"
16.
 "Lipid nanoparticle acts as a potential adjuvant for influenza split vaccine without inducing inflammatory responses; Shirai S., Kawai A., Shibuya M., Munakata L., Omata D., Suzuki R., Yoshioka Y., Vaccines, 8(3), 433, (2020)"
17.
 "Characterization of brain-targeted drug delivery enhanced by acombination of lipid-based microbubbles and non-focused ultrasound; Omata D., Hagiwara F., Munakata L., Shima T., Kageyama S., Suzuki Y., Azuma T., Takagi S., Seki K., Maruyama K., Suzuki R.; J. Pharm Sci, 109(9), 2827-2835 (2020)"
18.
 Lipid-based microbubbles and ultrasound for therapeutic application; Omata D, Unga J, Suzuki R, Maruyama K.; Adv. Drug. Deliv. Rev., 154-155, 236-244 (2020)
19.
 "Comprehensive screening of mouse T-cell epitopes in human herpesvirus 6B glycoprotein H/L/Q1/Q2 tetramer complex; Okutani M, Kawabata A, Nishimura M, Nagamata S, Kuwabara S, Haseda Y, Munakata L, Suzuki R, Mori Y, Aoshi T.; J. Immunol. Res., 2020, 4697529 (2020)"
20.
 New development of ultrasonic cancer therapy - The possibility and some of the difficulties; Kondo T., Suzuki R., Sasaki N., Takiguchi M., Thermal Med, 36, 75-90 (2020)
21.
 Scale-up production, characterization and toxicity of a freeze-dried lipid-stabilized microbubble formulation for ultrasound imaging and therapy; Unga J., Kageyama S., Suzuki R., Omata D., Maruyama K.; J. Liposome Res., 30(3), 297-304 (2020)
22.
 Lipid nanoparticles potentiate CpG-Oligodeoxynucleotide-based vaccine for influenza virus; Shirai S., Shibuya M., Kawai A., Tamiya S., Munakata L., Omata D., Suzuki R., Aoshi T., Yoshioka Y.; Front. Immunol., 10, 3018 (2019)
23.
 Microfluidic-prepared DOTAP nanoparticles induce strong T-cell responses in mice; Haseda Y., Munakata L., Meng J., Suzuki R., Aoshi T.; Plos One, 15(1), e0227891 (2019)
24.
 Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-microenvironment and activate CD8 T cells in mice; Munakata L., Tanimoto Y., Osa A., Meng J., Haseda Y., Natio Y., Machiyama H., Omata D., Maruyama K., Yoshioka Y., Okada Y., Koyama S., Suzuki R., Aoshi T.; J. Control. R
25.
 Effect of encapsulated gas on stability of lipid-based microbubbles and ultrasound-triggered drug delivery; Omata D., Maruyama T., Unga J., Hagiwara F., Munakata L., Kageyama S., Shima T., Suzuki Y., Maruyama K., Suzuki R.; J. Control. Release, 311-312, 2019
26.
 Development of antibody-modified nanobubbles using Fc-region-binding polypeptides for ultrasound imaging; Hamano N., Kamoshida S, Kikkawa Y., Yano Y., Kobayashi T., Endo-Takahashi Y., Suzuki R., Maruyama K., Ito Y, Nomizu M., Negishi Y.; Pharmaceutics, 11(6), E283 (2019)
27.
 Development and evaluation of stability and ultrasound response of DSPC-DPSG-based freeze-dried microbubbles. Unga J, Omata D, Kudo N, Ueno S, Munakata L, Shima T, Suzuki R, Maruyama K.; J. Liposome Res.; 29(4), 368-374 (2019)
28.
 Discovery of a sugar-based nanoparticle universally existing in boiling herbal water extracts and their immunostimulant effect. Iitsuka H, Koizumi K, Inujima A, Suzaki M, Mizuno Y, Takeshita Y, Eto T, Otsuka Y, Shimada R, Liu M, Ikeda K, Nakano M, Suzuki R, Maruyama K, Zhou Y, Sakurai H, Shibahara N. Biochem. Biophys. Rep. 16, 62-68 (2018)
29.
 Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer;Dasa SSK, Diakova G, Suzuki R, Mills AM, Gutknecht MF, Klibanov AL, Slack-Davis JK, Kelly KA;Theranostics 8(10): 2782-2798 (2018) doi: 10.7150/thno.23050
30.
 PMO Delivery System Using Bubble Liposomes and Ultrasound Exposure for Duchenne Muscular Dystrophy Treatment;Negishi Y, Ishii Y, Nirasawa K, Sasaki E, Endo-Takahashi Y, Suzuki R, Maruyama K.;Methods Mol Biol. 2018;1687:185-192.
31.
 Cancer Vaccine Therapy Using Tumor Endothelial Cells as Antigens Suppresses Solid Tumor Growth and Metastasis.;Nomura T, Hirata K, Shimaoka T, Yamakawa M, Koizumi N, Suzuki R, Maruyama K, Utoguchi N.;Biol Pharm Bull. 2017;40(10):1661-1668.
32.
 Epidermal growth factor receptor-targeted sonoporation with microbubbles enhances therapeutic efficacy in a squamous cell carcinoma model.;Hirabayashi F, Iwanaga K, Okinaga T, Takahashi O, Ariyoshi W, Suzuki R, Sugii M, Maruyama K, Tominaga K, Nishihara T.;PLoS One. 2017 Sep 22;12(9):e0185293
33.
 Efficient delivery of signal-responsive gene carriers for disease-specific gene expression via bubble liposomes and sonoporation.;Tsuchiya A, Kang JH, Mori T, Naritomi Y, Kushio S, Niidome T, Tachibana K, Takahashi Y, Negishi Y, Oda Y, Suzuki R, Maruyama K, Katayama Y.;Colloids Surf B Biointerfaces. 2017 Dec 1;160:60-64
34.
 The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection.;Abdalkader R, Kawakami S, Unga J, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M.;Drug Deliv. 2017 Nov;24(1):320-327.
35.
 Evaluation of pharmacokinetic and pharmacodynamic profiles of liposomes for the cell type-specific delivery of small molecule drugs.;Dasa SSK, Suzuki R, Mugler E, Chen L, Jansson-L?fmark R, Micha?lsson E, Lindfors L, Klibanov AL, French BA, Kelly KA.;Nanomedicine. 2017 Nov;13(8):2565-2574
36.
 The Development of Mechanically Formed Stable Nanobubbles Intended for Sonoporation-mediated Gene Transfection. Abdalkader R, Kawakami S, Unga J, Higuch Y, Suzuki R, Maruyama K, Yamashida F, Hashida M, Drug. Deliv. 24(1), 320-327 (2017)
37.
 Preparation of Angiopep-2 Peptide-Modified Bubble Liposomes for Delivery to the Brain. Endo-Takahashi Y, Ooaku K, Ishida K, Suzuki R, Maruyama K, Negishi Y, Biol. Pharm. Bull. 39(6), 977-983 (2016)
38.
 Tumor Growth Suppression by the Combination of Nanobubbles and Ultrasound. Suzuki R, Oda Y, Omata D, Nishiie N, Koshima R, Shiono Y, Sawaguchi Y, Unga J, Naoi T, Negishi Y, Kawakami S, Hashida M, Maruyama K, Cancer Sci. 107(3), 217-223 (2016)
39.
 MicroRNA Imaging in Combination with Diagnostic Ultrasound and Bubble Liposomes for MicroRNA Delivery. Endo-Takahashi Y, Negishi Y, Suzuki R, Maruyama K, Aramaki Y, Methods Mol. Biol, 1372, 209-213, 2016
40.
 Co-administration of Microbubbles and Drugs in Ultrasound-Assisted Drug Delivery: Comparison with Drug-Carrying Particles. Suzuki R, Klibanov AL, Adv. Exp. Med. Biol., 880, 205-220 (2016)
41.
 Development of target-specific liposomes for delivering small molecule drugs after reperfused myocardial infarction. Dasa SS, Suzuki R, Gutknecht M, Brinton LT, Tian Y, Michaelsson E, Lindfors L, Klibanov AL, French BA, Kelly KA, J. Controlled Release, 220, 556-567, 2015
42.
 Preliminary study on forming microbubble-surrounded cells as carriers for cellular therapy and evaluation of ultrasound controllability by fluorescence imaging. Fumi Demachi, Yuta Murayama, Naoto Hosaka, Takashi Mochizuki, Kohji Masuda, Shin Enosawa, Toshio Chiba, Yusuke Oda, Ryo Suzuki, Kazuo Maruyama, Japanese J. Applied Physics, 54, 07HF19 (2015)
43.
 Development of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane. Yusuke Oda, Ryo Suzuki, Tetsuya Mori, Hideyo Takahashi, Hideaki Natsugari, Daiki Omata, Johan Unga, Hitoshi Uruga, Mutsumi Sugii, Shigeru Kawakami, Yuriko Higuchi, Fumiyoshi Yamashita, Mitsuru Hashida, Kazuo Maruyama, Int. J. Pharm., 487, 64-71 (2015)
44.
 Enhancement of Blood-Brain Barrier Permeability and Delivery of Antisense Oligonucleotides or Plasmid DNA to the Brain by the Combination of Bubble Liposomes and High-Intensity Focused Ultrasound. Negishi Y, Yamane M, Kurihara N, Endo-Takahashi Y, Sashida S, Takagi N, Suzuki R, Maruyama K, Pharmaceutics, 7, 344-362 (2015)
45.
 Evaluation of the potential of doxorubicin loaded microbubbles as a theranostic modality using a murine tumor model. Abdalkader R, Kawakami S, Unga J, Suzuki R, Maruyama K, Yamashita F, Hashida M, ActaBiomater, 19, 112-118 (2015)
46.
 Nonviral　gene delivery systems by the combination of bubble liposomes and ultrasound. Omata D, Negishi Y, Suzuki R, Oda Y, Endo-Takahashi Y, Maruyama K, Adv. Genet., 89, 25-48 (2015)
47.
 Liposomal bubble/ultrasound-mediated delivery of cellular signal-responsive gene carriers for disease-specific gene expression. Akira Tsuchiya, Takeshi Mori, Satoshi Kushio, Yuki Naritomi, Jeong-Hun Kang, Takuro Niidome, Katsuro Tachibana, Yoko Takahashi, Yoichi Negishi, Yusuke Oda, Ryo Suzuki, Kazuo Maruyama, Yoshiki Katayama., Mol. Pharm.
48.
 The potential role of CXCL17/VCC1/DMC in early tumor progression. Aya Matsui, Takashi Murakami, Yoichi Negishi, Yoko Endo-Takahashi, Ryo Suzuki, Ichiro Kadouchi, Nicole A.L. Chun, Kazuo Maruyama, Yukihiko Aramaki, Kentaro Semba, Eiji Kobayashi, Masafumi Takahashi, Can. Res.
49.
 Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice. Kurosaki T, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Sasaki H, Yamashita F, Hashida M, Nanomed: nanotechnol. Biol. Med., 10, 1829-1838 (2014)
50.
 Gene Delivery to Periodontal Tissue using Bubble Liposomes and Ultrasound. Marika Sugano, Yoichi Negishi, Yoko Endo-Takahashi, Nobuhito Hamano, Michihiko Usui, Ryo Suzuki, Kazuo Maruyama, Yukihiko Aramaki, Matsuo Yamamoto, J. Periodontal Res., 49, 398-404 (2014)
51.
 Evaluation of active control of Bubble liposomes in a bifurcated flow under various ultrasound conditions. Ren Koda, Jun Koido, Naoto Hosaka, Shinya Onogi, Takashi Mochizuki, Kohji Masuda, Ryo Suzuki, Kazuo Maruyama, Adv. Biomed. Eng., 3, 21-28 (2014)
52.
 Bubble liposomes and ultrasound exposure improve localized morpholino oligomer delivery into the skeletal muscles of dystrophic mdx mice. Yoichi Negishi, Yuko Ishii, Hitomi Shiono, Saki Akiyama, Shoko Sekine, Takuo Kojima, Sayaka Mayama, Taiki Kikuchi, Nobuhito Hamano, Yoko Endo-Takahashi, Ryo Suzuki, Kazuo Maruyama, Yukihiko Aramaki, Molecular Pharm., 11, 1053-1061(2014)
53.
 Combination of Bubble liposomes and high-intensity focused ultrasound (HIFU) enhanced antitumor effect by tumor ablation. N. Hamano, Y. Negishi, K. Takatori, Y. E. Takahashi , R. Suzuki, K. Maruyama, T. Niidome, Y. Aramaki. Biological & Pharmaceutical Bulletin 37(1), 174-177, 2014.
54.
 Development of anionic bubble lipopolyplexes for efficient and safe gene transfection with ultrasound exposure in mice. Tomoaki Kurosaki, Shigeru Kawakami, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Hitoshi Sasaki, Fumiyoshi Yamashita, and Mitsuru Hashida, J. Controlled Release, 176, 24-34 (2014)
55.
 Systemic delivery of miR-126 by miRNA-loaded Bubble liposomes for the treatment of hindlimb ischemia. Yoko Endo-Takahashi, Yoichi Negishi, Arisa Nakamura, Saori Ukai, Kotomi Ooaku, Yusuke Oda, Katsutoshi Sugimoto, Fuminori Moriyasu, Norio Takagi, Ryo Suzuki, Kazuo Maruyama & Yukihiko Aramaki, Scientific Reports, 4, 3883, 2014
56.
 Thrombus targeted perfluorocarbon containing liposomal bubbles for enhancement of ultrasonic thrombolysis in vitro and in vivo study -. K. Hagisawa, T. Nishioka, R. Suzuki, K. Maruyama, Y. Nishida, K. Iida, H. Luo, R. J. Siegel. J. Thrombosis and Haemostasis.　11, 1565-1573, 2013
57.
 Bubble Liposomes and Ultrasound Enhance the Antitumor Effects of AG73 Liposomes Encapsulating Antitumor Agents. Hamano N, Negishi Y, Omata D, Takahashi Y, Manandhar M, Suzuki R, Maruyama K, Nomizu M, Aramaki Y. Mol Pharm., 10(2), 774-779, 2013
58.
 Suppression of murine collagen-induced arthritis by vaccination of synovial vascular endothelial cells. Y. Sawaguchi, K. Hirata, R. Suzuki, N. Utoguchi, K. Maruyama. Life Sciences 92. 1125-1130. 2013
59.
 Ultrasound-mediated Gene Delivery Systems by AG73-modified Bubble Liposomes. Y. Negishi, Y. Tsunoda, N. Hamano, D.Omata, Y. E. Takahashi, R. Suzuki, K. Maruyama, M. Nomizu, and Y. Aramaki. Biopolymers. 100 (4) . 402-407. 2013.
60.
 pDNA-loaded bubble liposomes as potential ultrasound imaging and gene delivery agents. Y. E. Takahashi, Y. Negishi, A. Nakamura, D. Suzuki, S. Ukai, K. Sugimoto, F.i Mariyasu, N. Takagi, R. Suzuki, K. Maruyama, Y. Aramaki. Biomaterials. 34. 2807-2813. 2013.
61.
 AG73-modified Bubble liposomes for targeted ultrasound imaging of tumor neovasculature. Y. Negishi, N. Hamano, Y. Tsunoda, Y. Oda, Ba. Choijamts, Y. Takahashi, D. Omata, R. Suzuki, K. Maruyama, M. Nomizu, M. Emoto, Y. Aramaki. Biomaterials 34. 501-507. 2013
62.
 Mild-hyperthermia by the Combination of Liposomal Nanobubbles and Non-focused Ultrasound. R. SUZUKI, Y. ODA, D. OMATA, Y. SAWAGUCHI, M. SEKI, H. URUGA, T. NAOI, Y. NEGISHI, K. MARUYAMA. Thermal Medicine 29（２）37-46.　2013
63.
 Selective gene transfer to the retina using intravitreal ultrasound irradiation, Shozo Sonoda, Katsuro Tachibana, Toshifumi Yamashita, Makoto Shirasawa, Hiroto Terasaki, Eisuke Uchino, Ryo Suzuki, Kazuo Maruyama and Taiji Sakamoto. J. Ophthalmology. 412752. 2012
64.
 Selective gene transfer to the retina using intravitreal ultrasound irradiation, Shozo Sonoda, Katsuro Tachibana, Toshifumi Yamashita, Makoto Shirasawa, Hiroto Terasaki, Eisuke Uchino, Ryo Suzuki, Kazuo Maruyama and Taiji Sakamoto. J. Ophthalmology. 412752. 2012
65.
 Prophylactic immunization with Bubble liposomes and ultrasound-treated dendritic cells provided a four-fold decrease in the frequency of melanoma lung metastasis. Yusuke Oda, Ryo Suzuki, Shota Otake, Norihito Nishiie, Keiichi Hirata, Risa Koshima, Tetsuya Nomura, Naoki Utoguchi, Nobuki Kudo, Katsuro Tachibana, Kazuo Maruyama. J. Controlled Release. 160. 362-366. 2012
66.
 Involvement of Ca2+ and ATP in Enhanced Gene Delivery by Bubble Liposomes and Ultrasound Exposure. Omata D, Negishi Y, Yamamura S, Hagiwara S, Endo-Takahashi Y, Suzuki R, Maruyama K, Nomizu M, Aramaki Y. Mol. Pharm. 9. 1017-1023. 2012
67.
 CXCL17 Expression by Tumor Cells Recruits CD11b+Gr1highF4/802 Cells and Promotes Tumor Progression. Aya Matsui, Hideaki Yokoo, Yoichi Negishi, Yoko Endo-Takahashi, Nicole A. L. Chun, Ichiro Kadouchi, Ryo Suzuki, Kazuo Maruyama, Yukihiko Aramaki, Kentaro Semba, Eiji Kobayashi, Masafumi Takahashi, Takashi Murakami. PLOS ONE. 7. e44080 August 2012.
68.
 Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation. Keita Un, Shigeru Kawakami, Mitsuru Yoshida, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita, Mitsuru Hashida. Hepatology, 56. 259-269. 2012
69.
 Enhancement of ultrasonic thrombus imaging using novel liposomal bubbles targeting activated platelet glycoprotein IIb/IIIa complex-in vitro and in vivo study. Hagisawa K, Nishioka T, Suzuki R, Takizawa T, Maruyama K, Takase B, Ishihara M, Kurita A, Yoshimoto N, Ohsuzu F, Kikuchi M. Int. J. Cardiol. 152, 202-206, 2011
70.
 Synergistic effect of ultrasound and antibiotics against Chlamydia trachomatis-infected human epithelial cells in vitro. Yurika Ikeda-Dantsuji, Loreto B. Feril Jr., Katsuro Tachibana, Koichi Ogawa, Hitomi Endo, Yoshimi Harada, Ryo Suzuki, Kazuo Maruyama. Ultrasonics Sonochem. 18, 425-430, 2011
71.
 Delivery of an Angiogenic Gene into Ischemic Muscle by Novel Bubble Liposomes Followed by Ultrasound Exposure. Yoichi Negishi, Keiko Matsuo, Yoko Endo-Takahashi, Kentaro Suzuki, Yuuki Matsuki, Norio Takagi, Ryo Suzuki, Kazuo Maruyama, and Yukihiko Aramaki. Pharm. Res., 28. 712-719. 2011
72.
 Suppression of melanoma growth and metastasis by DNA vaccination using an ultrasound-responsive and mannose-modified gene carrier. Keita Un, Shigeru Kawakami, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita and Mitsuru Hashida. Molecular Pharmaceutics. 8, 543-554, 2011
73.
 A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors. Kouichi Shiraishi, Reiko Endoh, Hiroshi Furuhata, Masamichi, Nishihara, Yusuke Oda, Ryo Suzuki, Kazuo Maruyama, Jun-ichiro Jo, Yasuhiko Tabata, Jun Yamamoto, Masayuki Yokoyama, Int. J. Pharm., 421, 379-387, 2011
74.
 Combination of ultrasound and bubble liposome enhance the effect of doxorubicin and inhibit murine osteosarcoma growth. Ueno Y, Sonoda S, Suzuki R, Yokouchi M, Kawasoe Y, Tachibana K, Maruyama K, Sakamoto T, Komiya S. Cancer Biol Ther., 12, 270-277, 2011
75.
 Bubble liposomes and ultrasound promoted endosomal escape of TAT-PEG liposomes as gene delivery carriers. Omata D, Negishi Y, Hagiwara S, Yamamura S, Endo-Takahashi Y, Suzuki R, Maruyama K, Nomizu M, Aramaki Y. Mol. Pharm. 8. 2416-23. 2011
76.
 Local Gene Delivery System by Bubble liposomes and Ultrasound exposure into Joint Synovium. Yoichi Negishi, Yuka Tsunoda, Yoko Endo-Takahashi, Yusuke Oda, Ryo Suzuki, Kazuo Maruyama, Matsuo Yamamoto, and Yukihiko Aramaki. J. Drug Delivery 203986, 2011
77.
 The elucidation of gene transferring mechanism by ultrasound-responsive unmodified and mannose- modified lipoplexes. Keita Una, Shigeru Kawakamia, Mitsuru Yoshidaa, Yuriko Higuchia, Ryo Suzuki,Kazuo Maruyama, Fumiyoshi Yamashita and Mitsuru Hashidaa. Biomaterials. 32. 4659-69. 2011
78.
 Involvement of activated transcriptional process in efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure. Keita Un, Shigeru Kawakami, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita and Mitsuru Hashida. J Controlled Release. 20. 355-363. 2011
79.
 Progress in the development of ultrasound-mediated gene delivery systems utilizing nano- and microbubbles, Ryo Suzuki, Yusuke Oda, Naoki Utoguchi, Kazuo Maruyama, J. Controlled Release. 149, 36-41, 2011
80.
 Intracellular targeting delivery of liposomal drugs for tumor delivery based on EPR effects, Kazuo Maruyama, Advanced Drug Delivery Rev., 63, 161-169, 2011
Publication List (Books and others)
1.
 Development of Ultrasound Theranostics for Cancer. Suzuki R, Maruyama K. Yakugaku Zasshi 138 (7), 919-922, 2018
2.
 Cancer therapy with nanotechnology-based drug delivery systems -Applications and challenges of liposome technologies for advanced cancer therapy-. Ryo Suzuki, Daiki Omata, Yusuke Oda, Johan Unga, Yoichi Negishi, Kazuo Maruyama. In Nanomaterials in Pharmacology (Ed. By Zheng-Rong Lu, Shinji Sakuma), 457-482, Springer, New York 2016
3.
 Development of new freeze dried bubble for ultrasound imaging and therapy. J. Unga. D. Omata. Y. Oda. Mutsumi Sugii, Hitoshi Uruga, R. Suzuki, Kazuo Maruyama. Progress in Drug Delivery System, 24, 45-49, 2015.
4.
 Ultrasound-Mediated Delivery Systems Using Nano/Microbubbles or Bubble Liposomes, Kazuo Maruyama, Ryo Suzuki, Yusuke Oda, Yoko Endo-Takahashi, Yoichi Negishi in Bio-Nanotechnology: A revolution in food, biomedical and health sciences. (Ed. by E.Bagchi, M. Bagchi, H. Moriyama, F. Shahidi), pp227-245 Jhon Whily & Sons Ltd. UK 2013
5.
 Ultrasound-targeted bubble liposome destruction enhances AG73-mediated gene transfer by improvement of intracellular trafficking. Daiki Omata, Yoichi Negishi, Yoko Endo-Takahashi, Ryo Suzuki, Kazuo Maruyama, Motoyoshi Nomizu, and Yukihiko Aramaki. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 326-329. Melville, New York, 2011
6.
 Characterisation of gene delivery using liposomal bubbles and ultrasound. Risa Koshima, Ryo Suzuki, Yusuke Oda Keiichi Hirata, Tetsuya Nomura, Yoichi Negishi, Naoki Utoguchi, Nobuki Kudo and Kazuo Maruyama. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 330-334. Melville, New York, 2011
7.
 Intramuscular injection of angiogenic gene with bubble liposomes followed by ultrasound exposure to improve angiogenesis. Yoichi Negishi, Keiko Matsuo, Yoko Endo-Takahashi, Kentaro Suzuki, Yuuki Matsuki, Norio Takagi, Ryo Suzuki, Kazuo Maruyama, and Yukihiko Aramaki. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 335-399. Melville, New York, 2011
8.
 Novel siRNA-loaded bubble liposomes with ultrasound exposure for RNA interference. Yoko Endo-Takahashi, Yoichi Negishi, Ryo Suzuki, Kazuo Maruyama, and Yukihiko Aramaki. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 340-344. Melville, New York, 2011
9.
 Anti-tumor mechanism in IL-12 gene therapy using liposomal bubbles and ultrasound. Ryo Suzuki, Yusuke Oda, Risa Koshima, Keiichi Hirata Tetsuya Nomura, Yoichi Negishi, Naoki Utoguchi Shinsaku Nakagawa and Kazuo Maruyama. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 345-350. Melville, New York, 2011
10.
 Anti-tumor effects from dendritic cell-based cancer immunotherapy using liposomal bubbles and ultrasound. Yusuke Oda, Ryo Suzuki, Keiichi Hirata, Tetsuya Nomura, Naoki Utoguchi and Kazuo Maruyama. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 351-355. Melville, New York, 2011
11.
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