 帝京大学薬学部 |
研究室ページ | English | |
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論文リスト | |
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1.
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Viability variation of T-cells under ultrasound exposure according to adhesion condition with bubbles; Kajita N., Ito Y., Watanabe S., Miyamaoto Y., Omata D., Maruyama K., Suzuki R., MasudaK.: J. Med. Ultrason, (2023) in press | |
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2.
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Feasibility study of novel nanoparticles derived from Glycyrrhizae radix as vaccine adjuvant for cancer immunotherapy; Suzuki Y., Munakata L., Omata D., Koisumi K., Suzuki R.; Immunotherapy, 14(18), 1443-1455 (2022) | |
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3.
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Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain; Ogawa K., Kato N., Yoshida M., Hiu T., Matsuo T., Mizukami S., Omata D., Suzuki R., Mauryama K., Mukai H., Kawakami S. J. Control. Release, 348, 34-41, (2022) | |
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4.
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Ultrasound-directed enzyme-prodrug therapy (UDEPT) using self-immolative doxorubicin derivatives; Roemhild K., Besse HC., Wang B., Pena Q., Sun Q., Omata D., Ozbakir B., Bos C., Scheeren HW., Storm G., Metselaar JM., Yu H., Knuchel-Clarke R., Kiessling F., Moonen CTW., Deckers R., Shi Y., Lammers T. Theranostics, 12(10) 4791-4801 (2022) | |
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5.
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Ultrasound and microbubble-mediated drug delivery and immunotherapy. Daiki Omata, Munakata Lisa, Maruyama Kazuo, Ryos Suzuki, J. Med. Ultrason. (2022) in press | |
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6.
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Ultrasound image-guided gene delivery using three-dimensional diagnostic ultrasound and lipid-based microbubbles, Daiki Omata, Lisa Munakata, Saori Kageyama, Yuno Suzuki, Tamotsu Maruyama, Tadamitsu Shima, Takumi Chikaarashi, Naoya Kajita, Kohji Masuda, Naoto Tsuchiya, Kazuo Maruyama, Ryo Suzuki, J. Drug Target. 30(2) 200-207 (2022) | |
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7.
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Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery, Omata Daiki, Lisa Munakata, Kazuo Maruyama, Ryo Suzuki, Biol Pharm Bull 44(10) 1391-1398 (2021) | |
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8.
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Ternary Complexes of pDNA, Neuron-Binding Peptide, and PEGylated Polyethyleneimine for Brain Delivery with Nano-Bubbles and Ultrasound. Endo-Takahashi Y., Kurokawa R., Sato K., Takizawa N., Katagiri F., Hamano N., Suzuki R., Maruyama K., Nomizu M., Takagi N., Negishi Y., Pharmaceutics. 13(7):1003 (2021) | |
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9.
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Development of combination adjuvant for efficient T cell and antibody response induction against protein antigen. Haseda Y., Munakata L., Kimura C., Kinugasa-Katayama Y., Mori Y., Suzuki R., Aoshi T., PLoS One. 16(8):e0254628 (2021) | |
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10.
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HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells; Kashio T., Shirakura K., Kinoshita M., Morita M., Ishiba R., Muraoka K., Kanbara T., Tanaka M., Funatsu R., Hino N., Koyama S., Suzuki R., Yoshioka Y., Aoshi T., Doi T., Okada Y.; Tissue Barriers, (2021) 9(3), 1911195, (2021) | |
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11.
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Lipid bubbles combined with low-intensity ultrasound enhance the intratumoral accumulation and antitumor effect of pegylated liposomal doxorubicin in vivo; Yokoe I., Omata D., Unga J., Suzuki R., Mauryama K., Okamoto Y., Osaki T.; Drug. Deliv., 28(1), 530-541 (2021) | |
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12.
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Enhanced antitumor activity of combined lipid bubble ultrasound and anticancer drugs in gynecological cervical cancers; Yamaguchi K., Matumoto Y., Suzuki R., Nishida H., Omata D., Inaba H., Kukita A., Tanikawa M., Sone K., Oda K., Osuga Y., Maruyama K., Fujii T.; Cancer Sci., (2021) ,112(6), 2493-2503 (2021) | |
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13.
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Inhibition of miR-96-5p in the mouse brain increases glutathione leveles by altering NOVA1 expression; Kinoshita C., Kikuchi-Utsumi K., Aoyama K., Suzuki R., Okamoto Y., Matsumura N., Omata D., Maruyama K., Nakaki T.; Commun. Biol., 4(1), 182 (2021) | |
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14.
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Effect of lipid shell composition in DSPG-based microbubbles on blood flow imaging with ultrasonography; Maruyama T., Sugii M., Omata D., Unga J., Shima T., Munakata L., Kageyama S., Hagiwara F., Suzuki Y., Maruyama K., Suzuki R.; Int J. Pharm., 590, 119886 (2020) | |
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15.
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"A pilot study on efficacy of lipid bubbles for theranostics in dogs with tumors; Yokoe I., Murahata Y., Harada K., Sunden Y., Omata D., Unga J., Suzuki R., Mruyama K., Okamoto Y., Osaki T.; Cancers, 12(9), 2423 (2020)" | |
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16.
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"Lipid nanoparticle acts as a potential adjuvant for influenza split vaccine without inducing inflammatory responses; Shirai S., Kawai A., Shibuya M., Munakata L., Omata D., Suzuki R., Yoshioka Y., Vaccines, 8(3), 433, (2020)" | |
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17.
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"Characterization of brain-targeted drug delivery enhanced by acombination of lipid-based microbubbles and non-focused ultrasound; Omata D., Hagiwara F., Munakata L., Shima T., Kageyama S., Suzuki Y., Azuma T., Takagi S., Seki K., Maruyama K., Suzuki R.; J. Pharm Sci, 109(9), 2827-2835 (2020)" | |
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18.
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Lipid-based microbubbles and ultrasound for therapeutic application; Omata D, Unga J, Suzuki R, Maruyama K.; Adv. Drug. Deliv. Rev., 154-155, 236-244 (2020) | |
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19.
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"Comprehensive screening of mouse T-cell epitopes in human herpesvirus 6B glycoprotein H/L/Q1/Q2 tetramer complex; Okutani M, Kawabata A, Nishimura M, Nagamata S, Kuwabara S, Haseda Y, Munakata L, Suzuki R, Mori Y, Aoshi T.; J. Immunol. Res., 2020, 4697529 (2020)" | |
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20.
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New development of ultrasonic cancer therapy - The possibility and some of the difficulties; Kondo T., Suzuki R., Sasaki N., Takiguchi M., Thermal Med, 36, 75-90 (2020) | |
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21.
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Scale-up production, characterization and toxicity of a freeze-dried lipid-stabilized microbubble formulation for ultrasound imaging and therapy; Unga J., Kageyama S., Suzuki R., Omata D., Maruyama K.; J. Liposome Res., 30(3), 297-304 (2020) | |
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22.
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Lipid nanoparticles potentiate CpG-Oligodeoxynucleotide-based vaccine for influenza virus; Shirai S., Shibuya M., Kawai A., Tamiya S., Munakata L., Omata D., Suzuki R., Aoshi T., Yoshioka Y.; Front. Immunol., 10, 3018 (2019) | |
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23.
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Microfluidic-prepared DOTAP nanoparticles induce strong T-cell responses in mice; Haseda Y., Munakata L., Meng J., Suzuki R., Aoshi T.; Plos One, 15(1), e0227891 (2019) | |
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24.
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Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-microenvironment and activate CD8 T cells in mice; Munakata L., Tanimoto Y., Osa A., Meng J., Haseda Y., Natio Y., Machiyama H., Omata D., Maruyama K., Yoshioka Y., Okada Y., Koyama S., Suzuki R., Aoshi T.; J. Control. Release, 313, 106-119 (2019) | |
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25.
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Effect of encapsulated gas on stability of lipid-based microbubbles and ultrasound-triggered drug delivery; Omata D., Maruyama T., Unga J., Hagiwara F., Munakata L., Kageyama S., Shima T., Suzuki Y., Maruyama K., Suzuki R.; J. Control. Release, 311-312, 2019 | |
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26.
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Development of antibody-modified nanobubbles using Fc-region-binding polypeptides for ultrasound imaging; Hamano N., Kamoshida S, Kikkawa Y., Yano Y., Kobayashi T., Endo-Takahashi Y., Suzuki R., Maruyama K., Ito Y, Nomizu M., Negishi Y.; Pharmaceutics, 11(6), E283 (2019) | |
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27.
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Development and evaluation of stability and ultrasound response of DSPC-DPSG-based freeze-dried microbubbles. Unga J, Omata D, Kudo N, Ueno S, Munakata L, Shima T, Suzuki R, Maruyama K.; J. Liposome Res.; 29(4), 368-374 (2019) | |
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28.
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Discovery of a sugar-based nanoparticle universally existing in boiling herbal water extracts and their immunostimulant effect. Iitsuka H, Koizumi K, Inujima A, Suzaki M, Mizuno Y, Takeshita Y, Eto T, Otsuka Y, Shimada R, Liu M, Ikeda K, Nakano M, Suzuki R, Maruyama K, Zhou Y, Sakurai H, Shibahara N. Biochem. Biophys. Rep. 16, 62-68 (2018) | |
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29.
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Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer;Dasa SSK, Diakova G, Suzuki R, Mills AM, Gutknecht MF, Klibanov AL, Slack-Davis JK, Kelly KA;Theranostics 8(10): 2782-2798 (2018) doi: 10.7150/thno.23050 | |
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30.
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PMO Delivery System Using Bubble Liposomes and Ultrasound Exposure for Duchenne Muscular Dystrophy Treatment;Negishi Y, Ishii Y, Nirasawa K, Sasaki E, Endo-Takahashi Y, Suzuki R, Maruyama K.;Methods Mol Biol. 2018;1687:185-192. | |
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31.
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Cancer Vaccine Therapy Using Tumor Endothelial Cells as Antigens Suppresses Solid Tumor Growth and Metastasis.;Nomura T, Hirata K, Shimaoka T, Yamakawa M, Koizumi N, Suzuki R, Maruyama K, Utoguchi N.;Biol Pharm Bull. 2017;40(10):1661-1668. | |
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32.
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Epidermal growth factor receptor-targeted sonoporation with microbubbles enhances therapeutic efficacy in a squamous cell carcinoma model.;Hirabayashi F, Iwanaga K, Okinaga T, Takahashi O, Ariyoshi W, Suzuki R, Sugii M, Maruyama K, Tominaga K, Nishihara T.;PLoS One. 2017 Sep 22;12(9):e0185293 | |
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33.
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Efficient delivery of signal-responsive gene carriers for disease-specific gene expression via bubble liposomes and sonoporation.;Tsuchiya A, Kang JH, Mori T, Naritomi Y, Kushio S, Niidome T, Tachibana K, Takahashi Y, Negishi Y, Oda Y, Suzuki R, Maruyama K, Katayama Y.;Colloids Surf B Biointerfaces. 2017 Dec 1;160:60-64 | |
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34.
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The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection.;Abdalkader R, Kawakami S, Unga J, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M.;Drug Deliv. 2017 Nov;24(1):320-327. | |
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35.
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Evaluation of pharmacokinetic and pharmacodynamic profiles of liposomes for the cell type-specific delivery of small molecule drugs.;Dasa SSK, Suzuki R, Mugler E, Chen L, Jansson-L?fmark R, Micha?lsson E, Lindfors L, Klibanov AL, French BA, Kelly KA.;Nanomedicine. 2017 Nov;13(8):2565-2574 | |
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36.
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The Development of Mechanically Formed Stable Nanobubbles Intended for Sonoporation-mediated Gene Transfection. Abdalkader R, Kawakami S, Unga J, Higuch Y, Suzuki R, Maruyama K, Yamashida F, Hashida M, Drug. Deliv. 24(1), 320-327 (2017) | |
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37.
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Preparation of Angiopep-2 Peptide-Modified Bubble Liposomes for Delivery to the Brain. Endo-Takahashi Y, Ooaku K, Ishida K, Suzuki R, Maruyama K, Negishi Y, Biol. Pharm. Bull. 39(6), 977-983 (2016) | |
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38.
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Tumor Growth Suppression by the Combination of Nanobubbles and Ultrasound. Suzuki R, Oda Y, Omata D, Nishiie N, Koshima R, Shiono Y, Sawaguchi Y, Unga J, Naoi T, Negishi Y, Kawakami S, Hashida M, Maruyama K, Cancer Sci. 107(3), 217-223 (2016) | |
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39.
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MicroRNA Imaging in Combination with Diagnostic Ultrasound and Bubble Liposomes for MicroRNA Delivery. Endo-Takahashi Y, Negishi Y, Suzuki R, Maruyama K, Aramaki Y, Methods Mol. Biol, 1372, 209-213, 2016 | |
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40.
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Co-administration of Microbubbles and Drugs in Ultrasound-Assisted Drug Delivery: Comparison with Drug-Carrying Particles. Suzuki R, Klibanov AL, Adv. Exp. Med. Biol., 880, 205-220 (2016) | |
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41.
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Development of target-specific liposomes for delivering small molecule drugs after reperfused myocardial infarction. Dasa SS, Suzuki R, Gutknecht M, Brinton LT, Tian Y, Michaelsson E, Lindfors L, Klibanov AL, French BA, Kelly KA, J. Controlled Release, 220, 556-567, 2015 | |
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42.
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Preliminary study on forming microbubble-surrounded cells as carriers for cellular therapy and evaluation of ultrasound controllability by fluorescence imaging. Fumi Demachi, Yuta Murayama, Naoto Hosaka, Takashi Mochizuki, Kohji Masuda, Shin Enosawa, Toshio Chiba, Yusuke Oda, Ryo Suzuki, Kazuo Maruyama, Japanese J. Applied Physics, 54, 07HF19 (2015) | |
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43.
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Development of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane. Yusuke Oda, Ryo Suzuki, Tetsuya Mori, Hideyo Takahashi, Hideaki Natsugari, Daiki Omata, Johan Unga, Hitoshi Uruga, Mutsumi Sugii, Shigeru Kawakami, Yuriko Higuchi, Fumiyoshi Yamashita, Mitsuru Hashida, Kazuo Maruyama, Int. J. Pharm., 487, 64-71 (2015) | |
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44.
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Enhancement of Blood-Brain Barrier Permeability and Delivery of Antisense Oligonucleotides or Plasmid DNA to the Brain by the Combination of Bubble Liposomes and High-Intensity Focused Ultrasound. Negishi Y, Yamane M, Kurihara N, Endo-Takahashi Y, Sashida S, Takagi N, Suzuki R, Maruyama K, Pharmaceutics, 7, 344-362 (2015) | |
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45.
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Evaluation of the potential of doxorubicin loaded microbubbles as a theranostic modality using a murine tumor model. Abdalkader R, Kawakami S, Unga J, Suzuki R, Maruyama K, Yamashita F, Hashida M, ActaBiomater, 19, 112-118 (2015) | |
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46.
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Nonviral gene delivery systems by the combination of bubble liposomes and ultrasound. Omata D, Negishi Y, Suzuki R, Oda Y, Endo-Takahashi Y, Maruyama K, Adv. Genet., 89, 25-48 (2015) | |
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47.
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Liposomal bubble/ultrasound-mediated delivery of cellular signal-responsive gene carriers for disease-specific gene expression. Akira Tsuchiya, Takeshi Mori, Satoshi Kushio, Yuki Naritomi, Jeong-Hun Kang, Takuro Niidome, Katsuro Tachibana, Yoko Takahashi, Yoichi Negishi, Yusuke Oda, Ryo Suzuki, Kazuo Maruyama, Yoshiki Katayama., Mol. Pharm. | |
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48.
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The potential role of CXCL17/VCC1/DMC in early tumor progression. Aya Matsui, Takashi Murakami, Yoichi Negishi, Yoko Endo-Takahashi, Ryo Suzuki, Ichiro Kadouchi, Nicole A.L. Chun, Kazuo Maruyama, Yukihiko Aramaki, Kentaro Semba, Eiji Kobayashi, Masafumi Takahashi, Can. Res. | |
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49.
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Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice. Kurosaki T, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Sasaki H, Yamashita F, Hashida M, Nanomed: nanotechnol. Biol. Med., 10, 1829-1838 (2014) | |
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50.
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Gene Delivery to Periodontal Tissue using Bubble Liposomes and Ultrasound. Marika Sugano, Yoichi Negishi, Yoko Endo-Takahashi, Nobuhito Hamano, Michihiko Usui, Ryo Suzuki, Kazuo Maruyama, Yukihiko Aramaki, Matsuo Yamamoto, J. Periodontal Res., 49, 398-404 (2014) | |
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51.
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Evaluation of active control of Bubble liposomes in a bifurcated flow under various ultrasound conditions. Ren Koda, Jun Koido, Naoto Hosaka, Shinya Onogi, Takashi Mochizuki, Kohji Masuda, Ryo Suzuki, Kazuo Maruyama, Adv. Biomed. Eng., 3, 21-28 (2014) | |
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52.
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Bubble liposomes and ultrasound exposure improve localized morpholino oligomer delivery into the skeletal muscles of dystrophic mdx mice. Yoichi Negishi, Yuko Ishii, Hitomi Shiono, Saki Akiyama, Shoko Sekine, Takuo Kojima, Sayaka Mayama, Taiki Kikuchi, Nobuhito Hamano, Yoko Endo-Takahashi, Ryo Suzuki, Kazuo Maruyama, Yukihiko Aramaki, Molecular Pharm., 11, 1053-1061(2014) | |
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53.
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Combination of Bubble liposomes and high-intensity focused ultrasound (HIFU) enhanced antitumor effect by tumor ablation. N. Hamano, Y. Negishi, K. Takatori, Y. E. Takahashi , R. Suzuki, K. Maruyama, T. Niidome, Y. Aramaki. Biological & Pharmaceutical Bulletin 37(1), 174-177, 2014.
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54.
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４種類のリドカイン製剤(院内製剤)における基剤の検討(The base I four types of lidocain preparation (formulated in Hospital))、山岡 尚世, 斎藤 百枝美, 丸山 桂司, 渡部 多真紀, 丸山 一雄, 鈴木 亮, 渡辺 茂和, 土屋 雅勇, 内田 佳孝, 望月 正人, 山辺 智代, 山岡 桂子, 平林 慎一, Yakugaku-Zasshi, 134(2), 249-258, 2014 | |
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55.
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Development of anionic bubble lipopolyplexes for efficient and safe gene transfection with ultrasound exposure in mice. Tomoaki Kurosaki, Shigeru Kawakami, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Hitoshi Sasaki, Fumiyoshi Yamashita, and Mitsuru Hashida, J. Controlled Release, 176, 24-34 (2014) | |
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56.
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Systemic delivery of miR-126 by miRNA-loaded Bubble liposomes for the treatment of hindlimb ischemia. Yoko Endo-Takahashi, Yoichi Negishi, Arisa Nakamura, Saori Ukai, Kotomi Ooaku, Yusuke Oda, Katsutoshi Sugimoto, Fuminori Moriyasu, Norio Takagi, Ryo Suzuki, Kazuo Maruyama & Yukihiko Aramaki, Scientific Reports, 4, 3883, 2014 | |
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57.
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Thrombus targeted perfluorocarbon containing liposomal bubbles for enhancement of ultrasonic thrombolysis in vitro and in vivo study -. K. Hagisawa, T. Nishioka, R. Suzuki, K. Maruyama, Y. Nishida, K. Iida, H. Luo, R. J. Siegel. J. Thrombosis and Haemostasis. 11, 1565-1573, 2013
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58.
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Bubble Liposomes and Ultrasound Enhance the Antitumor Effects of AG73 Liposomes Encapsulating Antitumor Agents. Hamano N, Negishi Y, Omata D, Takahashi Y, Manandhar M, Suzuki R, Maruyama K, Nomizu M, Aramaki Y. Mol Pharm., 10(2), 774-779, 2013
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59.
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Suppression of murine collagen-induced arthritis by vaccination of synovial vascular endothelial cells. Y. Sawaguchi, K. Hirata, R. Suzuki, N. Utoguchi, K. Maruyama. Life Sciences 92. 1125-1130. 2013
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60.
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Ultrasound-mediated Gene Delivery Systems by AG73-modified Bubble Liposomes. Y. Negishi, Y. Tsunoda, N. Hamano, D.Omata, Y. E. Takahashi, R. Suzuki, K. Maruyama, M. Nomizu, and Y. Aramaki. Biopolymers. 100 (4) . 402-407. 2013.
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61.
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pDNA-loaded bubble liposomes as potential ultrasound imaging and gene delivery agents. Y. E. Takahashi, Y. Negishi, A. Nakamura, D. Suzuki, S. Ukai, K. Sugimoto, F.i Mariyasu, N. Takagi, R. Suzuki, K. Maruyama, Y. Aramaki. Biomaterials. 34. 2807-2813. 2013.
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62.
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AG73-modified Bubble liposomes for targeted ultrasound imaging of tumor neovasculature. Y. Negishi, N. Hamano, Y. Tsunoda, Y. Oda, Ba. Choijamts, Y. Takahashi, D. Omata, R. Suzuki, K. Maruyama, M. Nomizu, M. Emoto, Y. Aramaki. Biomaterials 34. 501-507. 2013
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63.
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Mild-hyperthermia by the Combination of Liposomal Nanobubbles and Non-focused Ultrasound. R. SUZUKI, Y. ODA, D. OMATA, Y. SAWAGUCHI, M. SEKI, H. URUGA, T. NAOI, Y. NEGISHI, K. MARUYAMA. Thermal Medicine 29（２）37-46. 2013
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64.
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Selective gene transfer to the retina using intravitreal ultrasound irradiation, Shozo Sonoda, Katsuro Tachibana, Toshifumi Yamashita, Makoto Shirasawa, Hiroto Terasaki, Eisuke Uchino, Ryo Suzuki, Kazuo Maruyama and Taiji Sakamoto. J. Ophthalmology. 412752. 2012
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65.
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Selective gene transfer to the retina using intravitreal ultrasound irradiation, Shozo Sonoda, Katsuro Tachibana, Toshifumi Yamashita, Makoto Shirasawa, Hiroto Terasaki, Eisuke Uchino, Ryo Suzuki, Kazuo Maruyama and Taiji Sakamoto. J. Ophthalmology. 412752. 2012
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66.
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Prophylactic immunization with Bubble liposomes and ultrasound-treated dendritic cells provided a four-fold decrease in the frequency of melanoma lung metastasis. Yusuke Oda, Ryo Suzuki, Shota Otake, Norihito Nishiie, Keiichi Hirata, Risa Koshima, Tetsuya Nomura, Naoki Utoguchi, Nobuki Kudo, Katsuro Tachibana, Kazuo Maruyama. J. Controlled Release. 160. 362-366. 2012
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67.
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Involvement of Ca2+ and ATP in Enhanced Gene Delivery by Bubble Liposomes and Ultrasound Exposure. Omata D, Negishi Y, Yamamura S, Hagiwara S, Endo-Takahashi Y, Suzuki R, Maruyama K, Nomizu M, Aramaki Y. Mol. Pharm. 9. 1017-1023. 2012
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68.
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CXCL17 Expression by Tumor Cells Recruits CD11b+Gr1highF4/802 Cells and Promotes Tumor Progression. Aya Matsui, Hideaki Yokoo, Yoichi Negishi, Yoko Endo-Takahashi, Nicole A. L. Chun, Ichiro Kadouchi, Ryo Suzuki, Kazuo Maruyama, Yukihiko Aramaki, Kentaro Semba, Eiji Kobayashi, Masafumi Takahashi, Takashi Murakami. PLOS ONE. 7. e44080 August 2012.
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69.
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Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation. Keita Un, Shigeru Kawakami, Mitsuru Yoshida, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita, Mitsuru Hashida. Hepatology, 56. 259-269. 2012
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70.
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Enhancement of ultrasonic thrombus imaging using novel liposomal bubbles targeting activated platelet glycoprotein IIb/IIIa complex-in vitro and in vivo study. Hagisawa K, Nishioka T, Suzuki R, Takizawa T, Maruyama K, Takase B, Ishihara M, Kurita A, Yoshimoto N, Ohsuzu F, Kikuchi M. Int. J. Cardiol. 152, 202-206, 2011
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71.
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Synergistic effect of ultrasound and antibiotics against Chlamydia trachomatis-infected human epithelial cells in vitro. Yurika Ikeda-Dantsuji, Loreto B. Feril Jr., Katsuro Tachibana, Koichi Ogawa, Hitomi Endo, Yoshimi Harada, Ryo Suzuki, Kazuo Maruyama. Ultrasonics Sonochem. 18, 425-430, 2011
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72.
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Delivery of an Angiogenic Gene into Ischemic Muscle by Novel Bubble Liposomes Followed by Ultrasound Exposure. Yoichi Negishi, Keiko Matsuo, Yoko Endo-Takahashi, Kentaro Suzuki, Yuuki Matsuki, Norio Takagi, Ryo Suzuki, Kazuo Maruyama, and Yukihiko Aramaki. Pharm. Res., 28. 712-719. 2011
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73.
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Suppression of melanoma growth and metastasis by DNA vaccination using an ultrasound-responsive and mannose-modified gene carrier. Keita Un, Shigeru Kawakami, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita and Mitsuru Hashida. Molecular Pharmaceutics. 8, 543-554, 2011
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74.
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A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors. Kouichi Shiraishi, Reiko Endoh, Hiroshi Furuhata, Masamichi, Nishihara, Yusuke Oda, Ryo Suzuki, Kazuo Maruyama, Jun-ichiro Jo, Yasuhiko Tabata, Jun Yamamoto, Masayuki Yokoyama, Int. J. Pharm., 421, 379-387, 2011
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75.
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Combination of ultrasound and bubble liposome enhance the effect of doxorubicin and inhibit murine osteosarcoma growth. Ueno Y, Sonoda S, Suzuki R, Yokouchi M, Kawasoe Y, Tachibana K, Maruyama K, Sakamoto T, Komiya S. Cancer Biol Ther., 12, 270-277, 2011
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76.
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Bubble liposomes and ultrasound promoted endosomal escape of TAT-PEG liposomes as gene delivery carriers. Omata D, Negishi Y, Hagiwara S, Yamamura S, Endo-Takahashi Y, Suzuki R, Maruyama K, Nomizu M, Aramaki Y. Mol. Pharm. 8. 2416-23. 2011
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77.
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Local Gene Delivery System by Bubble liposomes and Ultrasound exposure into Joint Synovium. Yoichi Negishi, Yuka Tsunoda, Yoko Endo-Takahashi, Yusuke Oda, Ryo Suzuki, Kazuo Maruyama, Matsuo Yamamoto, and Yukihiko Aramaki. J. Drug Delivery 203986, 2011
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78.
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The elucidation of gene transferring mechanism by ultrasound-responsive unmodified and mannose- modified lipoplexes. Keita Una, Shigeru Kawakamia, Mitsuru Yoshidaa, Yuriko Higuchia, Ryo Suzuki,Kazuo Maruyama, Fumiyoshi Yamashita and Mitsuru Hashidaa. Biomaterials. 32. 4659-69. 2011
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79.
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Involvement of activated transcriptional process in efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure. Keita Un, Shigeru Kawakami, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita and Mitsuru Hashida. J Controlled Release. 20. 355-363. 2011
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80.
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リポソームと遺伝子発現タグを利用したがん細胞に対する新規アクティブターゲティングシステムの開発（The liposome-based targeting system by the combination of tag ligand and genetically expressed tag protein）佐藤紗也佳, 真柴拓哉, 本田亜紀, Citterio Daniel, 小田雄介, 鈴木 亮, 丸山一雄, 鈴木孝治Progress in Drug Delivery System, 20, 103-108, 2011.
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81.
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超音波応答性リポソームの開発とその医療応用に向けた基礎的検討 鈴木亮、小田雄介、丸山一雄 超音波TECHNO、23、81-84、2011
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総説リスト | |
1. |
腫瘍新生血管オープニングによるがん治療、大崎智弘、横江祈、鈴木亮、小俣大樹、丸山一雄、メディカル・サイエンス・ダイジェスト（MSD） 47(10) 38-40 (2021) | |
2. |
Development of new freeze dried bubble for ultrasound imaging and therapy. J. Unga. D. Omata. Y. Oda. Mutsumi Sugii, Hitoshi Uruga, R. Suzuki, Kazuo Maruyama. Progress in Drug Delivery System, 24, 45-49, 2015. | |
3. |
小児シロップ剤とマウス空腹時血糖値の変動 山岡 尚世, 齋藤 百枝美, 坂本 吉正, 渡部 多真紀, 丸山 一雄, 鈴木 亮, 内田 佳孝, 望月 正人, 丸山 桂司, 渡辺 茂和, 土屋 雅勇, 児玉 浩子, 山岡 桂子, 平林 慎一, Yakugaku-Zasshi?、2014 | |
4. |
バブルリポソームと超音波を用いた遺伝子導入法のがん治療への応用 小田雄介、鈴木亮、小俣大樹、Unga Johan、宇留賀仁史、杉井むつみ、丸山一雄、 超音波TECHNO 5-6, 66-69、2015 | |
5. |
セラノスティクスの構築に向けた超音波応答性バブルリポソームによる遺伝子・核酸デリバリー 根岸洋一、高橋葉子、鈴木亮、丸山一雄、新槇幸彦、Drug Delivery System, 29 (4), 285-293, 2014. | |
6. |
超音波診断・治療システム（超音波セラノスティックス）開発の現状と展望 鈴木 亮, 小田雄介, 小俣大樹, 澤口能一, 根岸洋一, 丸山一雄. INNERVISION 29 (7), 49-52. 2014 | |
7. |
超音波遺伝子導入装置 小俣大樹、丸山一雄 Drug Delivery System, 29 (5), 456-458, 2014. | |
8. |
眼組織における低照射エネルギー超音波の利用 （Application of Ultrasound-enhanced Gene and Drug Delivery to the Ocular Tissue） 園田祥三、山下敏史、鈴木 亮、丸山一雄、坂本泰二、YAKUGAKU ZASSHI 133 (12), 1269-1276, 2013 | |
9. |
ナノテクノロジーが拓く新たな超音波診断・治療技術 （Novel Daignastics and Therapeutics with Ultrasound Technologies and Nanotechnologies） 鈴木 亮、小田雄介、小俣大樹、澤口能一、根岸洋一、丸山一雄、 YAKUGAKU ZASSHI 133 (12), 1263-1268, 2013 | |
10. |
バブルリポソームと超音波を利用した新規がん治療戦略 鈴木 亮、小田雄介、小俣大樹、澤口能一、丸山一雄、根岸洋一、超音波TECHNO 9-10. 52-56. 2013 | |
11. |
バブルリポソームと超音波を用いて抗原送達した樹状細胞の免疫によるがん転移予防効果 小田雄介、鈴木 亮、関むつみ、小俣大樹、澤口能一、宇留賀仁史、丸山一雄、 超音波TECHNO 9-10. 41-45. 2013 | |
12. |
バブリポソームを利用した超音波セラノスティクス. 鈴木亮、丸山一雄 ファルマシア 49, 660-664, 2013 | |
13. |
Novel Strategies for Ultrasound Diagnostics and Therapeutics by Micro/Nanobubbles. R Suzuki, Y. Sawaguchi, M. Seki, H. Uruga, T. Naoi, Y. Negishi, K. Maruyama．Thermal Med. 29, 37-46, 2013 | |
14. |
超音波セラノスティックス Ultrasound Theranostics 丸山一雄、小田雄介、小俣大樹、鈴木亮、薬剤学 73, 194-202, 2013 | |
15. |
バブルリポソームと超音波技術を利用した治療と診断 丸山一雄、小俣大樹、鈴木亮、小田雄介、澤口能一、ファインケミカル（シーエムシー出版）42, 39-43, 2013 | |
16. |
siRNA delivery system using bubble liposomes and ultrasound. Yoichi Negishi, Yoko Endo-Takahashi, Ryo Suzuki, Kazuo Maruyama, Yukihiko Aramaki. J. DRUG DEL. SCI. TECH., 22 (1) 91-97 2012 | |
17. |
筋ジストロフィー治療に向けた超音波核酸デリバリーシステムの開発 (The development of an ultrasound-mediated nucleic acid delivery system for treating muscular dystrophies) 根岸洋一，濱野展人, 塩野 瞳, 秋山早希, 高橋（遠藤）葉子，鈴木亮，丸山一雄，新槇幸彦. YAKUGAKU ZASSHI 132(12), 1383-1388, 2012 | |
18. |
Progress in the development of ultrasound-mediated gene delivery systems utilizing nano- and microbubbles, Ryo Suzuki, Yusuke Oda, Naoki Utoguchi, Kazuo Maruyama, J. Controlled Release. 149, 36-41, 2011 | |
19. |
Intracellular targeting delivery of liposomal drugs for tumor delivery based on EPR effects, Kazuo Maruyama, Advanced Drug Delivery Rev., 63, 161-169, 2011 | |
20. |
超音波応答性リポソームの開発とその医療応用に向けた基礎的検討 鈴木亮、小田雄介、丸山一雄 超音波TECHNO、23、81-84、2011 | |
21. |
バブルリポソームと超音波を利用した薬物・遺伝子デリバリー. 小田雄介、丸山一雄 医学の歩み (医歯薬出版株式会社) 238 (2) 169-173. 2011 | |
22. |
トランスフェリン修飾リポソームによる細胞内送達とがん治療への応用、平田圭一・鈴木 亮・小田雄介・野村 鉄也・宇都口直樹・丸山一雄、 日本血液代替物学会会誌「人工血液」 19, 17-24, 2011 | |
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23.
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リポソーム技術と超音波技術を基盤とした革新的がん治療システムの構築、鈴木亮、小田雄介、平田圭一、野村鉄也、宇都口直樹、丸山一雄、ケミカルエンジニアリング （化学工業社） 56(2), 50-54, 2011 | |
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著書リスト・その他 | |
1. |
血液脳関門と超音波 薬物動態視点から、鈴木亮、小俣大樹、Clinical Neuroscience 40(2) 222-227 (2022) | |
2. |
ファインバブルの超音波診断・治療への応用、鈴木 亮、最近の化学工学70 進化するファインバブル技術と応用展開 第11章 119-129化学工学会 関東支部編 化学工学会 ファインバブル学会連合著2022年3月2日発行 | |
3. |
Development of Ultrasound Theranostics for Cancer. Suzuki R, Maruyama K. Yakugaku Zasshi 138 (7), 919-922, 2018 | |
4. |
微小気泡を用いた新たな医療/診断システム -超音波セラノティクス 小田雄介、鈴木 亮、丸山一雄、 バイオサイエンスとインダストリー 74(5), 396-401 (2016) | |
5. |
Cancer therapy with nanotechnology-based drug delivery systems -Applications and challenges of liposome technologies for advanced cancer therapy-. Ryo Suzuki, Daiki Omata, Yusuke Oda, Johan Unga, Yoichi Negishi, Kazuo Maruyama. In Nanomaterials in Pharmacology (Ed. By Zheng-Rong Lu, Shinji Sakuma), 457-482, Springer, New York 2016 | |
6. |
微小バブル製剤の活用展開と現場ニーズ 丸山一雄、宇留賀仁史、杉井むつみ、鈴木亮 マイクロバブル（ファインバブル）のメカニズム・特性制御と実際応用のポイント 株式会社情報機構 東京 372-383、2015 | |
7. |
バブルリポソームと超音波によるDDS、 鈴木亮、丸山一雄、機能性DDSキャリアの製剤設計Drug Delivery using functional DDS caarriers (監修 岡田弘晃) pp259-268, シーエムシー出版 東京 2014年6月9日 | |
8. |
超音波を利用した新たな診断・治療システムを目指して 鈴木亮、丸山一雄 薬事日報 2014 | |
9. |
Ultrasound-Mediated Delivery Systems Using Nano/Microbubbles or Bubble Liposomes, Kazuo Maruyama, Ryo Suzuki, Yusuke Oda, Yoko Endo-Takahashi, Yoichi Negishi in Bio-Nanotechnology: A revolution in food, biomedical and health sciences. (Ed. by E.Bagchi, M. Bagchi, H. Moriyama, F. Shahidi), pp227-245 Jhon Whily & Sons Ltd. UK 2013 | |
10. |
バブルリポソーム、鈴木亮、小田雄介、小俣大樹、澤口能一、丸山一雄、応用が拡がるDDS ?人体環境から農業・家電までー （寺田弘、中川晋作、辻孝三、牧野公子、絹田精鎮、西野敦 編者）pp127-134、株式会社エヌ・ティー・エス 東京 2013年7月8日 | |
11. |
リポソームを用いたターゲティング、丸山一雄、小田雄介、小俣大樹、澤口能一、直井智幸、鈴木 亮、応用が拡がるDDS -人体環境から農業・家電まで- （寺田弘、中川晋作、辻孝三、牧野公子、絹田精鎮、西野敦 編者）pp47-55、株式会社エヌ・ティー・エス 東京 2013年7月8日 | |
12. |
超音波を利用したDDSの開発（第10節） 鈴木亮、小田雄介、丸山一雄、DDS製剤の開発・評価と実用化手法、629-634 技術情報協会 東京 2013年3月31日 | |
13. |
分布（第2章-２）丸山一雄、薬の生体内運命（中島恵美 編集）PP.86-112, ネオメディカル、神奈川 2013, ３月１5日 | |
14. |
リポソーム（第2章1．4）丸山一雄、小田雄介、小俣大樹、澤口能一、直井智幸、鈴木亮 遺伝子医学MOOK 別冊「ここまで広がるドラッグ徐放技術の最前線」（田畑泰彦 編集）、pp102-106、メディカルドゥ、大阪、2013 3月20日 | |
15. |
バーブルリポソームを利用したDDS （第５編、第３章、４節） 鈴木亮、小田雄介、丸山一雄 先端バイオマテリアルハンドブック pp.358-363 エヌ・ティー・エス、東京、2012 ６月15日刊. | |
16. |
Ultrasound-targeted bubble liposome destruction enhances AG73-mediated gene transfer by improvement of intracellular trafficking. Daiki Omata, Yoichi Negishi, Yoko Endo-Takahashi, Ryo Suzuki, Kazuo Maruyama, Motoyoshi Nomizu, and Yukihiko Aramaki. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 326-329. Melville, New York, 2011 | |
17. |
Characterisation of gene delivery using liposomal bubbles and ultrasound. Risa Koshima, Ryo Suzuki, Yusuke Oda Keiichi Hirata, Tetsuya Nomura, Yoichi Negishi, Naoki Utoguchi, Nobuki Kudo and Kazuo Maruyama. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 330-334. Melville, New York, 2011 | |
18. |
Intramuscular injection of angiogenic gene with bubble liposomes followed by ultrasound exposure to improve angiogenesis. Yoichi Negishi, Keiko Matsuo, Yoko Endo-Takahashi, Kentaro Suzuki, Yuuki Matsuki, Norio Takagi, Ryo Suzuki, Kazuo Maruyama, and Yukihiko Aramaki. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 335-399. Melville, New York, 2011 | |
19. |
Novel siRNA-loaded bubble liposomes with ultrasound exposure for RNA interference. Yoko Endo-Takahashi, Yoichi Negishi, Ryo Suzuki, Kazuo Maruyama, and Yukihiko Aramaki. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 340-344. Melville, New York, 2011 | |
20. |
Anti-tumor mechanism in IL-12 gene therapy using liposomal bubbles and ultrasound. Ryo Suzuki, Yusuke Oda, Risa Koshima, Keiichi Hirata Tetsuya Nomura, Yoichi Negishi, Naoki Utoguchi Shinsaku Nakagawa and Kazuo Maruyama. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 345-350. Melville, New York, 2011 | |
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21.
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Anti-tumor effects from dendritic cell-based cancer immunotherapy using liposomal bubbles and ultrasound. Yusuke Oda, Ryo Suzuki, Keiichi Hirata, Tetsuya Nomura, Naoki Utoguchi and Kazuo Maruyama. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 351-355. Melville, New York, 2011 | |
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22.
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Effective In Vitro and In Vivo Gene Delivery by The Combination of Liposomal Bubbles (Bubble liposomes) and Ultrasound Exposure, Suzuki R, Maruyama K in Liposomes, Methods and Protocols (Ed by Volkmar Weissig) Springer, New York. pp 473-486, 2010. | |
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主な発表（国際会議、国内学会など） | |
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1.
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New Delivery System with Bubble Liposomes and Ultrasound、Kazuo Maruyama, Yusuke Oda, Daiki Omata, Yoshikazu Sawaguchi, Ryo Suzuki、1st Meeting of Asia-Oceania Sonochemical Society（AOSS2013）、July 10-12, 2013、University of Melbourne, Australia | |
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2.
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Targeted gene delivery in liver by bubble liposomes and ultrasound、Daiki Omata, Ryo Suzuki, Yusuke Oda, Yoshikazu Sawaguchi, Yoichi Negishi, Kazuo Maruyama、CRS Annual Meeting 2013、Ｊｕｌｙ ２1?２５ 2013、Honolulu ＵＳＡ | |
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3.
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Brain Specific Gene Delivery by Bubble Liposomes and Ultrasound、Yusuke Oda, Ryo Suzuki, Daiki Omata, Yoshikazu Sawaguchi, Yoichi Negishi, Kazuo Maruyama、CRS Annual Meeting 2013、Ｊｕｌｙ ２1-２５ 2013、Honolulu ＵＳＡ | |
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4.
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Active Control of Bubble Liposome through Artificial Capillary by Using Matrix Array Transducer, Ren Koda, Naoto Hosaka, Shinya Onogi, Takashi Mochizuki, Kohji Masuda, Ryo Suzuki, Kazuo Maruyama、 2013 IEEE International Ultrasonics Symposium (IUS), 21 Jul - 25 Jul 2013, Prague, Czech Republic | |
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5.
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Selective Gene Delivery for Brain by Bubble Liposomes and Ultrasound, Daiki Omata Ryo Suzuki, Yusuke Oda, Yoshikazu Sawaguchi, Yoichi Negishi, Kazuo Maruyama, The 5th Asian Arden Conference, Ａｕｇａｓｔ 5-6 2013, Ｎａｇｏｙａ | |
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6.
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The thrombus imaging by thrombus targeted bubble liposome, Yoshikazu Sawaguchi, Ryo Suzuki, Yusuke Oda, Daiki Omata, Uruga Hitoshi, Mutsumi Seki, Kohsuke Hagisawa, Kazuo Maruyama, 第22回日本バイオイメージング学会学術集会, 2013年9月14〜16日, 東京大学薬学部 | |
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7.
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Development of thrombus-targeting bubble liposome for diagnostic and tPA thrombolysis acceleration, Yoshikazu Sawaguchi, Ryo Suzuki, Yusuke Oda, Daiki Omata, Kazuo Maruyama, 16th World Neurosonology Meeting, October 17-20, 2013, Sofia, Bulgaria | |
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8.
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Development of ultrasonic thrombus imaging agent using active targeting nanobubbles, Ryo Suzuki, Yoshikazu Sawaguchi, Kosuke Hagisawa, Yusuke Oda, Daiki Omata, Mutsumi Seki, Hitoshi Uruga, Kazuo Maruyama, World Molecular Imaging Congress 2013, October 25-27, 2013, Savannah, Georgia, US | |
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9.
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Studies on Cu complexes as therapeutic drugs for Menkes disease, Hideyo Takahashi, Paik Soong-a, Yujiro Hoshi, Norihiko Tani, Hideaki Natsugari, Mutsumi Seki, Ryo Suzuki, Kazuo Maruyama1, Mitsutoshi Munakata, Tomoko Hiroki, Hiroko Kodama. X ISTERH 2013: International Society of Trace Element Research in Humans, November 18-22, 2013, Ｔｏｋｙｏ | |
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10.
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Development of Selective Gene Delivery System for Brain by Bubble Liposomes and Ultrasound, Daiki Omata, Ryo Suzuki, Yusuke Oda, Yoshikazu Sawaguchi, Yoichi Negishi, Kazuo Maruyama, Asian Federation for Pharmaceutical Sciences Conference2013 (AFPS2013), Novenber 20-22, 2013, Jeju, Republic of Korea | |
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