Laboratory of Pharmacotherapeutics
Lab page | Japanese
Publication List (Journals)
1.
 Regulation of Endothelium-Reticulum-Stress-Mediated Apoptotic Cell Death by a Polymethoxylated Flavone, Nobiletin, Through the Inhibition of Nuclear Translocation of Glyceraldehyde 3-Phosphate Dehydrogenase in Retinal Müller cells; Miyata, Y., Matsumoto, K., Kusano, S., Kusakabe, Y., Katsura, Y., Oshitari, T. and Kosano, H.; Cells, 10(3), 669 (2021)
2.
 Potential Therapeutic Agents, Polymethoxylated Flavones Isolated from Kaempeferia parviflora for Cataract Prevention through Inhibition of Matrix Metalloproteinase-9 in Lens Epithelial Cells; Miyata, Y., Tatsuzaki, J., Yang, J. and Kosano, H.; Biol. Pharm. Bull., 42(10), 1658-1664 (2019)
3.
 In vitro studies on nobiletin isolated from citrus plants and the bioactive metabolites, inhibitory action against gelatinase enzymatic activity and the molecular mechanisms in human retinal Muller cell line.Miyata Y, Nagase T, Katsura Y, Takahashi H, Natsugari H, Oshitari T, Kosano H.@Biomed Pharmacother. 2017 Sep;93:70-80
4.
 Introduction of outcome-based education in pharmaceutical education in Japan.GTakahashi H.and@Kosano H.GYakugaku Zasshi. 2015;135(3):339-43.
5.
 Team-based Learning (TBL) Brings Active and Complementary Learning -Practice and Outcomes in Pharmacy Education; Yasuhara, T., Kosano, H.; YAKUGAKU ZASSHI, 134, 169-170 (2014)
6.
 Type I Collagen Accelerates the Spreading of Lens Epithelial Cells through the Expression and Activation of Matrix Metalloproteinases; Shimada, A., Miyata, Y., Kosano, H.; Curr. Eye Res., 1-12 (2014)
7.
 Cell-mediated contraction of vitreous explants from chicken embryo: Possibility of screening for therapeutic agents against proliferative vitreoretinal diseases; Oki, K., Miyata, Y., Shimada, A., Nagase, T., Katsura, Y., Kosano, H.; Mol. Vis., 19, 2374-2384 (2013)
8.
 Polymethoxyflavones as agents that prevent formation of cataract: Nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells; Miyata, Y., Oshitari, T., Okuyama, Y., Shimada, A., Takahashi, H., Natsugari, H., Kosano, H.; Bioorg. Med. Chem. Lett., 23, 183-187 (2013)
9.
 Protein kinase C-mediated regulation of matrix metalloproteinase and tissue inhibitor of metalloproteinase production in a human retinal m?ller cells.; Miyata Y, Kase M, Sugita Y, Shimada A, Nagase T, Katsura Y, Kosano H.; Curr Eye Res. 2012 Sep;37(9):842-9.
10.
 B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.; Oshitari T, Okuyama Y, Miyata Y, Kosano H, Takahashi H, Natsugari H.; Bioorg Med Chem. 2011 Dec 1;19(23):7085-92.
11.
 Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production.; Oshitari T, Okuyama Y, Miyata Y, Kosano H, Takahashi H, Natsugari H.;Bioorg Med Chem Lett. 2011 Aug 1;21(15):4540-4.
12.
 Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin.; Miyata Y, Tanaka H, Shimada A, Sato T, Ito A, Yamanouchi T, Kosano H.; Life Sci. 2011 Mar 28;88(13-14):613-8.
13.
 [Synthetic estrogens: some new pharmacological actions and mechanisms].; Kosano H.; Nihon Rinsho. 2008 Jan;66(1):104-10. Review. Japanese.
14.
 Erythropoietin is highly elevated in vitreous fluid of patients with proliferative diabetic retinopathy.; Katsura Y, Okano T, Matsuno K, Osako M, Kure M, Watanabe T, Iwaki Y,
Noritake M, Kosano H, Nishigori H, Matsuoka T.;Diabetes Care. 2005 Sep;28(9):2252-4.
15.
 A trial to assess the amount of insulin antibodies in diabetic patients by surface plasmon resonance.;Kure M, Katsura Y, Kosano H, Noritake M, Watanabe T, Iwaki Y, Nishigori H, Matsuoka T.; Intern Med. 2005 Feb;44(2):100-6.
16.
 Inhibition of glucocorticoid-induced cataracts in chick embryos by RU486: a model for studies on the role of glucocorticoids in development.; Nishigori H, Kosano H, Umeda IO, Nishigori H.; Life Sci. 2004 Nov 5;75(25):3027-33.
17.
 Involvement of hepatic glucocorticoid receptor-mediated functions in steroid-induced cataract formation.; Hamamichi S, Kosano H, Nakai S, Ogihara-Umeda I, Nishigori H.; Exp Eye Res. 2003 Nov;77(5):575-80.
18.
 Effects of endostatin in proliferative diabetic retinopathy. Ozaki, H., Katsura,Y., Noritake, M., Matsuno, K., Okano, T., Kosano, H., Nishigori, H., and Matsuoka, T. J. Tokyo.Med. Univ., 61(3), 226-231, 2003
19.
 Steroid-induced cataract: other than in the whole animal system, in the lens culture system, androgens, estrogens and progestins as well as glucocorticoids produce a loss of transparency of the lens.; Kosano H, Nishigori H.; Dev Ophthalmol. 2002;35:161-8.
20.
 Suppressive effects of thyroxine on glucocorticoid (gc)-induced metabolic changes and cataract formation on developing chick embryos.; Kosano H, Watanabe H, Nishigori H.; Exp Eye Res. 2001 Jun;72(6):643-8.
21.
 Stimulation of melanogenesis in murine melanoma cells by 2-mercapto-1-(beta-4-pyridethyl) benzimidazole (MPB).; Kosano H, Kayanuma T, Nishigori H.; Biochim Biophys Acta. 2000 Dec 11;1499(1-2):11-18.
22.
 Steroid-induced short term diabetes in chick embryo: reversible effects of insulin on metabolic changes and cataract formation.; Watanabe H, Kosano H, Nishigori H.; Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1846-52
23.
 ProMMP-9 (92 kDa gelatinase) in vitreous fluid of patients with proliferative diabetic retinopathy.; Kosano H, Okano T, Katsura Y, Noritake M, Kado S, Matsuoka T, Nishigori H.; Life Sci. 1999;64(25):2307-15.
24.
 The assembly of progesterone receptor-hsp90 complexes using purified proteins.; Kosano H, Stensgard B, Charlesworth MC, McMahon N, Toft D.; J Biol Chem. 1998 Dec 4;273(49):32973-9.
25.
 Hepatocyte growth factor in vitreous fluid of patients with proliferative diabetic retinopathy and other retinal disorders.; Katsura Y, Okano T, Noritake M, Kosano H, Nishigori H, Kado S, Matsuoka T.; Diabetes Care. 1998 Oct;21(10):1759-63.
26.
 Comparison of lens biochemistry and structure between BSO-treated and glucocorticoid-treated developing chick embryos.; Murakami I, Kosano H, Ogihara-Umeda I, Nishigori H, Uga S, Ishikawa S.; Exp Eye Res. 1996 Dec;63(6):673-81.
27.
 Pyrroloquinoline quinone (PQQ) inhibits the expression of tyrosinase mRNA by alpha-melanocyte stimulating hormone in murine B16 melanoma cells.; Kosano H, Setogawa T, Kobayashi K, Nishigori H.; Life Sci. 1995;56(20):1707-13.
28.
 Preventive effect of SA3443, a novel cyclic disulfide, on glucocorticoid-induced cataract formation of developing chick embryo.; Setogawa T, Kosano H, Ogihara-Umeda I, Kayanuma T, Nishigori H.; Exp Eye Res. 1994 Jun;58(6):689-95.
29.
 [Synthetic estrogens--new pharmacological actions and mechanisms].; Kosano H,
Nishigori H.; Nihon Rinsho. 1994 Mar;52(3):587-92. Review. Japanese.
30.
 Mode of action of estra-1,3,5(10)-triene-3, 17 beta-diol, 3-benzoate, 17[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy] acetate] (KM2210) on MCF-7 human breast tumours transplanted into nude mice.; Kubota T, Ishibiki K, Abe O, Kosano H, Ohsawa N, Hoffman RM.; Anticancer Res. 1993 Jul-Aug;13(4):935-40.
31.
 Growth-inhibitory action of an estrogen-chlorambucil conjugate (KM2210) in human breast cancer cell line MCF-7: its relation to reduction of estrogen receptor and transforming growth factor-alpha secretion.; Kosano H, Kubota T, Ohsawa N, Yamamori S, Abe O, Inagaki H, Nagata N.; Cancer Res. 1992 Mar 1;52(5):1187-91.
32.
 A case of asymptomatic cortisol producing adrenal adenoma.; Noritake M, Morimoto K, Kosano H, Nemoto Y, Kugai N, Takao M, Murai M, Tamai S, Tanaka K, Nagata N.; Endocrinol Jpn. 1992 Feb;39(1):19-24.
33.
 The effect of PGF2 alpha on parathyroid hormone-stimulated cyclic AMP production in mouse osteoblastic cell, MC3T3E1.; Wada S, Yasutomo Y, Kosano H, Kugai N, Nagata N.; Biochim Biophys Acta. 1991 May 24;1074(1):182-8.
34.
 Genesis of breast cancer in Japanese: a possible relationship between sex hormone binding globulin (SHBG) and serum lipid components.; Takatani O, Okumoto T, Kosano H.; Breast Cancer Res Treat. 1991 May;18 Suppl 1:S27-9.
35.
 Purification and partial sequencing of inhibitory factor on renal membrane adenylate cyclase in pancreatic cancer extract: identity with histones H1b or H1d.; Yasutomo Y, Suga T,
Wada S, Kosano H, Takishima K, Mamiya G, Kugai N, Nagata N.; Biochem Biophys Res Commun. 1991 Apr 15;176(1):255-61.
36.
 Inhibition of estradiol uptake and transforming growth factor alpha secretion in human breast cancer cell line MCF-7 by an alkyl-lysophospholipid.; Kosano H, Yasutomo Y, Kugai N,
Nagata N, Inagaki H, Tanaka S, Takatani O.; Cancer Res. 1990 Jun 1;50(11):3172-5.
37.
 Inhibition of renal membrane adenylate cyclase by extract of pancreatic cancer associated with humoral hypercalcemia of malignancy.; Yasutomo Y, Kugai N, Nagata N, Akatsu T, Wada S, Kinoshita T, Kosano H, Takatani O.; Bone Miner. 1990 May;9(2):111-20.
38.
 Increase of transferrin binding induced by an alkyl-lysophospholipid in breast cancer cells.; Kosano H, Takatani O.; J Lipid Mediat. 1990 Mar-Apr;2(2):117-21.
39.
 Inhibition by an alkyl-lysophospholipid of the uptake of epidermal growth factor in human breast cancer cell lines in relation to epidermal growth factor internalization.; Kosano H, Takatani O.; Cancer Res. 1989 Jun 1;49(11):2868-70.
40.
 Relationship between the levels of serum thyroid hormones or estrogen status and the risk of breast cancer genesis in Japanese women.; Takatani O, Okumoto T, Kosano H, Nishida M, Hiraide H, Tamakuma S.; Cancer Res. 1989 Jun 1;49(11):3109-12.
41.
 The tumor cells (FA-6) established from a pancreatic cancer associated with humoral hypercalcemia of malignancy: a simultaneous production of parathyroid hormone-like activity and transforming growth factor activity.; Nagata N, Akatsu T, Kugai N, Yasutomo Y, Kinoshita T, Kosano H, Shimauchi T, Takatani O, Ueyama Y.; Endocrinol Jpn. 1989 Feb;36(1):75-85.
42.
 Reduction of epidermal growth factor binding in human breast cancer cell lines by an alkyl-lysophospholipid.; Kosano H, Takatani O.;Cancer Res. 1988 Nov 1;48(21):6033-6.
43.
 On the activities of parathyroid hormone-like factor and transforming growth factors in extract of pancreatic cancer associated with humoral hypercalcemia of malignancy.; Akatsu T, Nagata N, Kugai N, Yasutomo Y, Kinoshita T, Kosano H, Takatani O, Takishima K, Mamiya G.; Acta Endocrinol (Copenh). 1988 Jun;118(2):232-8.
44.
 Distribution of estradiol and percentage of free testosterone in sera of Japanese women: preoperative breast cancer patients and normal controls.; Takatani O, Kosano H, Okumoto T, Akamatsu K, Tamakuma S, Hiraide H.; J Natl Cancer Inst. 1987 Dec;79(6):1199-204.
45.
 Enhancement of cyclic adenosine monophosphate content in bone cells by the factor extracted from a pancreatic cancer associated with hypercalcemia.; Nagata N, Kugai N, Maemura M, Akatsu T, Shimauchi T, Kinoshita T, Kosano H, Takatani O, Tsuda H, Fuse Y.; Metabolism. 1986 Jun;35(6):529-34.
46.
 Change in concentrations of myogenic components of serum during 93 h of strenuous physical exercise.; Kosano H, Kinoshita T, Nagata N, Takatani O, Isobe M, Yazaki Y.; Clin Chem. 1986 Feb;32(2):346-8.
Publication List (Books)