薬物治療学研究室
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論文リスト
1.
 Regulation of Endothelium-Reticulum-Stress-Mediated Apoptotic Cell Death by a Polymethoxylated Flavone, Nobiletin, Through the Inhibition of Nuclear Translocation of Glyceraldehyde 3-Phosphate Dehydrogenase in Retinal Muller cells; Miyata, Y., Matsumoto, K., Kusano, S., Kusakabe, Y., Katsura, Y., Oshitari, T. and Kosano, H.; Cells, 10(3), 669 (2021)
2.
 Potential Therapeutic Agents, Polymethoxylated Flavones Isolated from Kaempeferia parviflora for Cataract Prevention through Inhibition of Matrix Metalloproteinase-9 in Lens Epithelial Cells; Miyata, Y., Tatsuzaki, J., Yang, J. and Kosano, H.; Biol. Pharm. Bull., 42(10), 1658-1664 (2019)
3.
 In vitro studies on nobiletin isolated from citrus plants and the bioactive metabolites, inhibitory action against gelatinase enzymatic activity and the molecular mechanisms in human retinal Muller cell line; Miyata, Y., Nagase, T., Katsura, Y., Takahashi, H., Natsugari, H., Oshitari, T. and Kosano, H.; Biomed. Pharmacother., 93, 70-80 (2017)
4.
 6年制薬学部卒業時に必要とされる資質の具体例とその評価方法；高橋 寛, 小佐野 博史； 薬学雑誌
5.
 チーム基盤型学習（Team-based Learning; TBL）がもたらす能動的相補型学習　−薬学教育における実践とその成果−；　安原智久、小佐野博史；　YAKUGAKU ZASSHI 134, 169-170 (2014) 135 巻 (2015) 　339-343
6.
 Type I Collagen Accelerates the Spreading of Lens Epithelial Cells through the Expression and Activation of Matrix Metalloproteinases; Shimada, A., Miyata, Y., Kosano, H.; Curr. Eye Res., 1-12 (2014)"
7.
 Cell-mediated contraction of vitreous explants from chicken embryo: Possibility of screening for therapeutic agents against proliferative vitreoretinal diseases; Oki, K., Miyata, Y., Shimada, A., Nagase, T., Katsura, Y., Kosano, H.; Mol. Vis., 19, 2374-2384 (2013)
8.
 Polymethoxyflavones as agents that prevent formation of cataract: Nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells; Miyata, Y., Oshitari, T., Okuyama, Y., Shimada, A., Takahashi, H., Natsugari, H., Kosano, H.; Bioorg. Med. Chem. Lett., 23, 183-187 (2013)
9.
 Protein kinase C-mediated regulation of matrix metalloproteinase and tissue inhibitor of metalloproteinase production in a human retinal m?ller cells.; Miyata Y, Kase M, Sugita Y, Shimada A, Nagase T, Katsura Y, Kosano H.; Curr Eye Res. 2012 Sep;37(9):842-9.
10.
 基礎から臨床へ　後発白内障予防に向けての基礎研究　-新規フラボノイド化合物の可能性ー、
宮田佳樹、嶋田新、小佐野博史、白内障学会雑誌：２４、27-32、2012
11.
 B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.; Oshitari T, Okuyama Y, Miyata Y, Kosano H, Takahashi H, Natsugari H.; Bioorg Med Chem. 2011 Dec 1;19(23):7085-92.
12.
 Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production.; Oshitari T, Okuyama Y, Miyata Y, Kosano H, Takahashi H, Natsugari H.;Bioorg Med Chem Lett. 2011 Aug 1;21(15):4540-4.
13.
 Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin.; Miyata Y, Tanaka H, Shimada A, Sato T, Ito A, Yamanouchi T, Kosano H.; Life Sci. 2011 Mar 28;88(13-14):613-8.
14.
 [Synthetic estrogens: some new pharmacological actions and mechanisms].; Kosano H.; Nihon Rinsho. 2008 Jan;66(1):104-10. Review. Japanese.
15.
 Erythropoietin is highly elevated in vitreous fluid of patients with proliferative diabetic retinopathy.; Katsura Y, Okano T, Matsuno K, Osako M, Kure M, Watanabe T, Iwaki Y,
Noritake M, Kosano H, Nishigori H, Matsuoka T.;Diabetes Care. 2005 Sep;28(9):2252-4.
16.
 硝子体生理機能　-糖尿病網膜症ではなぜ硝子体に新生血管が伸展するかー、小佐野博史、
メディカルテクノロジー、３４（10）：1073-1077、2006
17.
 A trial to assess the amount of insulin antibodies in diabetic patients by surface plasmon resonance.;Kure M, Katsura Y, Kosano H, Noritake M, Watanabe T, Iwaki Y, Nishigori H, Matsuoka T.; Intern Med. 2005 Feb;44(2):100-6.
18.
 Inhibition of glucocorticoid-induced cataracts in chick embryos by RU486: a model for studies on the role of glucocorticoids in development.; Nishigori H, Kosano H, Umeda IO, Nishigori H.; Life Sci. 2004 Nov 5;75(25):3027-33.
19.
 Involvement of hepatic glucocorticoid receptor-mediated functions in steroid-induced cataract formation.; Hamamichi S, Kosano H, Nakai S, Ogihara-Umeda I, Nishigori H.; Exp Eye Res. 2003 Nov;77(5):575-80.
20.
 Effects of endostatin in proliferative diabetic retinopathy. Ozaki, H., Katsura,Y., Noritake, M., Matsuno, K., Okano, T., Kosano, H., Nishigori, H., and Matsuoka, T. J. Tokyo.Med. Univ., 61(3), 226-231, 2003
21.
 ステロイド白内障惹起因子の生成抑制と肝代謝能−ステロイド誘発鶏胚白内障モデルからの解析−、小佐野博史、日本白内障学会誌、１４、５−１２、２００２
22.
 Steroid-induced cataract: other than in the whole animal system, in the lens culture system, androgens, estrogens and progestins as well as glucocorticoids produce a loss of transparency of the lens.; Kosano H, Nishigori H.; Dev Ophthalmol. 2002;35:161-8.
23.
 Suppressive effects of thyroxine on glucocorticoid (gc)-induced metabolic changes and cataract formation on developing chick embryos.; Kosano H, Watanabe H, Nishigori H.; Exp Eye Res. 2001 Jun;72(6):643-8.
24.
 Stimulation of melanogenesis in murine melanoma cells by 2-mercapto-1-(beta-4-pyridethyl) benzimidazole (MPB).; Kosano H, Kayanuma T, Nishigori H.; Biochim Biophys Acta. 2000 Dec 11;1499(1-2):11-18.
25.
 Steroid-induced short term diabetes in chick embryo: reversible effects of insulin on metabolic changes and cataract formation.; Watanabe H, Kosano H, Nishigori H.; Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1846-52.
26.
 メラニン産生に対するキノン化合物の抑制作用。西郡秀夫、小佐野博史、太陽紫外線防御研究委員会学術報告、10(1)、53-62、2000.
27.
 ステロイド白内障とその予防。小佐野博史、西郡秀夫、あたらしい眼科、17(4)、549-553、2000.
28.
 ProMMP-9 (92 kDa gelatinase) in vitreous fluid of patients with proliferative diabetic retinopathy.; Kosano H, Okano T, Katsura Y, Noritake M, Kado S, Matsuoka T, Nishigori H.; Life Sci. 1999;64(25):2307-15.
29.
 The assembly of progesterone receptor-hsp90 complexes using purified proteins.; Kosano H, Stensgard B, Charlesworth MC, McMahon N, Toft D.; J Biol Chem. 1998 Dec 4;273(49):32973-9.
30.
 Hepatocyte growth factor in vitreous fluid of patients with proliferative diabetic retinopathy and other retinal disorders.; Katsura Y, Okano T, Noritake M, Kosano H, Nishigori H, Kado S, Matsuoka T.; Diabetes Care. 1998 Oct;21(10):1759-63.
31.
 Comparison of lens biochemistry and structure between BSO-treated and glucocorticoid-treated developing chick embryos.; Murakami I, Kosano H, Ogihara-Umeda I, Nishigori H, Uga S, Ishikawa S.; Exp Eye Res. 1996 Dec;63(6):673-81.
32.
 Pyrroloquinoline quinone (PQQ) inhibits the expression of tyrosinase mRNA by alpha-melanocyte stimulating hormone in murine B16 melanoma cells.; Kosano H, Setogawa T, Kobayashi K, Nishigori H.; Life Sci. 1995;56(20):1707-13.
33.
 Preventive effect of SA3443, a novel cyclic disulfide, on glucocorticoid-induced cataract formation of developing chick embryo.; Setogawa T, Kosano H, Ogihara-Umeda I, Kayanuma T, Nishigori H.; Exp Eye Res. 1994 Jun;58(6):689-95.
34.
 [Synthetic estrogens--new pharmacological actions and mechanisms].; Kosano H,
Nishigori H.; Nihon Rinsho. 1994 Mar;52(3):587-92. Review. Japanese.
35.
 Mode of action of estra-1,3,5(10)-triene-3, 17 beta-diol, 3-benzoate, 17[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy] acetate] (KM2210) on MCF-7 human breast tumours transplanted into nude mice.; Kubota T, Ishibiki K, Abe O, Kosano H, Ohsawa N, Hoffman RM.; Anticancer Res. 1993 Jul-Aug;13(4):935-40.
36.
 Growth-inhibitory action of an estrogen-chlorambucil conjugate (KM2210) in human breast cancer cell line MCF-7: its relation to reduction of estrogen receptor and transforming growth factor-alpha secretion.; Kosano H, Kubota T, Ohsawa N, Yamamori S, Abe O, Inagaki H, Nagata N.; Cancer Res. 1992 Mar 1;52(5):1187-91.
37.
 A case of asymptomatic cortisol producing adrenal adenoma.; Noritake M, Morimoto K, Kosano H, Nemoto Y, Kugai N, Takao M, Murai M, Tamai S, Tanaka K, Nagata N.; Endocrinol Jpn. 1992 Feb;39(1):19-24.
38.
 The effect of PGF2 alpha on parathyroid hormone-stimulated cyclic AMP production in mouse osteoblastic cell, MC3T3E1.; Wada S, Yasutomo Y, Kosano H, Kugai N, Nagata N.; Biochim Biophys Acta. 1991 May 24;1074(1):182-8.
39.
 Genesis of breast cancer in Japanese: a possible relationship between sex hormone binding globulin (SHBG) and serum lipid components.; Takatani O, Okumoto T, Kosano H.; Breast Cancer Res Treat. 1991 May;18 Suppl 1:S27-9.
40.
 Purification and partial sequencing of inhibitory factor on renal membrane adenylate cyclase in pancreatic cancer extract: identity with histones H1b or H1d.; Yasutomo Y, Suga T,
Wada S, Kosano H, Takishima K, Mamiya G, Kugai N, Nagata N.; Biochem Biophys Res Commun. 1991 Apr 15;176(1):255-61.
41.
 Inhibition of estradiol uptake and transforming growth factor alpha secretion in human breast cancer cell line MCF-7 by an alkyl-lysophospholipid.; Kosano H, Yasutomo Y, Kugai N,
Nagata N, Inagaki H, Tanaka S, Takatani O.; Cancer Res. 1990 Jun 1;50(11):3172-5.
42.
 Inhibition of renal membrane adenylate cyclase by extract of pancreatic cancer associated with humoral hypercalcemia of malignancy.; Yasutomo Y, Kugai N, Nagata N, Akatsu T, Wada S, Kinoshita T, Kosano H, Takatani O.; Bone Miner. 1990 May;9(2):111-20.
43.
 Increase of transferrin binding induced by an alkyl-lysophospholipid in breast cancer cells.; Kosano H, Takatani O.; J Lipid Mediat. 1990 Mar-Apr;2(2):117-21.
44.
 Inhibition by an alkyl-lysophospholipid of the uptake of epidermal growth factor in human breast cancer cell lines in relation to epidermal growth factor internalization.; Kosano H, Takatani O.; Cancer Res. 1989 Jun 1;49(11):2868-70.
45.
 Relationship between the levels of serum thyroid hormones or estrogen status and the risk of breast cancer genesis in Japanese women.; Takatani O, Okumoto T, Kosano H, Nishida M, Hiraide H, Tamakuma S.; Cancer Res. 1989 Jun 1;49(11):3109-12.
46.
 The tumor cells (FA-6) established from a pancreatic cancer associated with humoral hypercalcemia of malignancy: a simultaneous production of parathyroid hormone-like activity and transforming growth factor activity.; Nagata N, Akatsu T, Kugai N, Yasutomo Y, Kinoshita T, Kosano H, Shimauchi T, Takatani O, Ueyama Y.; Endocrinol Jpn. 1989 Feb;36(1):75-85.
47.
 Reduction of epidermal growth factor binding in human breast cancer cell lines by an alkyl-lysophospholipid.; Kosano H, Takatani O.;Cancer Res. 1988 Nov 1;48(21):6033-6.
48.
 On the activities of parathyroid hormone-like factor and transforming growth factors in extract of pancreatic cancer associated with humoral hypercalcemia of malignancy.; Akatsu T, Nagata N, Kugai N, Yasutomo Y, Kinoshita T, Kosano H, Takatani O, Takishima K,
Mamiya G.; Acta Endocrinol (Copenh). 1988 Jun;118(2):232-8.
49.
 Distribution of estradiol and percentage of free testosterone in sera of Japanese women: preoperative breast cancer patients and normal controls.; Takatani O, Kosano H, Okumoto T, Akamatsu K, Tamakuma S, Hiraide H.; J Natl Cancer Inst. 1987 Dec;79(6):1199-204.
50.
 Enhancement of cyclic adenosine monophosphate content in bone cells by the factor extracted from a pancreatic cancer associated with hypercalcemia.; Nagata N, Kugai N, Maemura M, Akatsu T, Shimauchi T, Kinoshita T, Kosano H, Takatani O, Tsuda H, Fuse Y.; Metabolism. 1986 Jun;35(6):529-34.
51.
 Change in concentrations of myogenic components of serum during 93 h of strenuous physical exercise.; Kosano H, Kinoshita T, Nagata N, Takatani O, Isobe M, Yazaki Y.; Clin Chem. 1986 Feb;32(2):346-8.
著書リスト・その他
1.
 コンパス薬物治療学　小佐野博史（共著）　　原　明義、小山　進(監修) 　南江堂　2018
2.
 あたらしい疾病薬学　小佐野博史（共著）　　小野寺憲治(監修) 　テコム(旧:医学評論社)　2016
3.
 放射薬品学　小佐野博史（共著・監修）　　南江堂　2015
4.
 Principal　Pharmacotherapy　小佐野博史（共著）　亀井淳三他（監修）　ネオメディカル　2015
5.
 わかりやすい疾病と処方薬の解説、小佐野博史、（佐藤哲男編集）、アークメディア、2012
6.
 薬学で学ぶ病態生化学　第2版　小佐野博史、（林秀徳、渡辺泰裕監修）、朝倉書店、2012
7.
 わかりやすい薬学生のための病態生理と薬物治療　第2版、ティ・エム・エス、2011
8.
 薬学生のための臨床実習マニュアル　（松田重三編集）、医学評論社、2011
9.
 薬学テキストシリーズ　薬物治療学、（小佐野博史、青山隆夫、山田安彦編集）朝倉書店、2009
10.
 薬学CBTコアカリ１　（薬学CBT対策編集委員会編）、　医学評論社、2009
11.
 Pharmacotherapy　（吉田正、亀井淳三編集）、ネオメディカル、2008
12.
 放射化学・放射性医薬品学、小佐野博史、（堀江正信、五郎丸毅他編集）、朝倉書店、東京、1998
13.
 白内障の薬物治療、小佐野博史、日本白内障屈折矯正手術学会雑誌（IOL＆RS)：２５（２）、158−161、2011
14.
 シンポジウムオーガナイザー印象記　−白内障メカニズムの解析−、小佐野博史、日本白内障学会誌、23、27、２０11
15.
 シンポジウムオーガナイザー印象記　−原因疾患と白内障ー基礎から臨床まで徹底研究−、
小佐野博史、日本白内障学会誌、22、22、２０１０
16.
 シンポジウムオーガナイザー印象記　−水晶体研究はどこへ向かうのか−、小佐野博史、
日本白内障学会誌、17、23、２００５
17.
 第36回水晶体研究会印象記、宮田佳樹、日本白内障学会誌、22、39、２０１０
18.
 US-Japan CCRG印象記、小佐野博史、日本白内障学会誌、14、42、２００３
19.
 薬科大学紹介２　帝京大学、小佐野博史、都薬雑誌：29（３）、42−44、2007
20.
 音楽と薬−愛の薬とニトログリセリン−、小佐野博史、MEDCHEM NEWS、２１（３）、54、2011