Faculty of Pharma Sciences, Teikyo University Publication | Japanese
Laboratory of Human Physiology & Pathology

Outline of Research
Goal: Pharmacotherapy to prevent progression of renal dysfunction (CKD)

1. Mechanisms of the pathogenesis of hyperuricemia
 
1) Sex difference, metabolic syndrome, and diuretic therapy related hyperuricemia
  
Although premenopausal women hardly affect hyperuricemia, one in five adult Japanese males
  affects it. The hyperuricemia seen in adult males is considered according to the metabolic
  syndrome. Diuretic therapy also induces hyperuricemia. We consider these environmental
  agents for hyperuricemia.
 2) Uric acid and brain.
  
Parkinson’s disease and Alzheimer disease were reported to be related to hyporuricemia.
  We consider the effect of uric acid to CNS.

2. Mechanism of the onset of proteinuria
 
1) Developing mechanisms of proteinuria in Alport syndrome
  
In order to create therapeutics of Alport syndrome, a rare hereditary kidney disease,
  we examined mouse model of Alport syndrome.


Staff
Professor Makoto Hosoyamada, M.D.,Ph.D.
Senior
Assistant
Professor
Masaru Doshi, Ph.D.
Fellow・Graduate Student