1. Mechanisms of the pathogenesis of hyperuricemia
　1) Sex difference, metabolic syndrome, and diuretic therapy related hyperuricemia
　　Although premenopausal women hardly affect hyperuricemia, one in five adult Japanese males
　　affects it. The hyperuricemia seen in adult males is considered according to the metabolic
　　syndrome. Diuretic therapy also induces hyperuricemia. We consider these environmental
　　agents for hyperuricemia.
　2) Uric acid and brain.
　　Parkinson’s disease and Alzheimer disease were reported to be related to hyporuricemia.
　　We consider the effect of　uric acid to CNS.

2. Mechanism of the onset of proteinuria
　1) Developing mechanisms of proteinuria in Alport syndrome
　　In order to create therapeutics of Alport syndrome, a rare hereditary kidney disease,
　　we examined mouse model of Alport syndrome.