Laboratory of Human Physiology & Pathology
	Lab page | Japanese
	Publication List (Journals)

1.	Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain. Tomioka NH, Tamura Y, Takada T, Shibata S, Suzuki H, Uchida S, Hosoyamada M. Fluids Barriers CNS. 2016 Dec 12;13(1):22.
2.	Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury. Hosoyamada M, Tsurumi Y, Hirano H, Tomioka NH, Sekine Y, Morisaki T, Uchida S. Nucleosides Nucleotides Nucleic Acids. 2016 Dec;35(10-12):543-549.
3.	Uric acid metabolism of kidney and intestine in a rat model of chronic kidney disease. Nagura M, Tamura Y, Kumagai T, Hosoyamada M, Uchida S. Nucleosides Nucleotides Nucleic Acids. 2016 Dec;35(10-12):550-558.
4.	Urinary excretion of uric acid, allantoin, and 8-OH-Deoxyguanosine in uricase-knockout mice. Inazawa K, Yamaguchi S, Hosoyamada M, Fukuuchi T, Tomioka NH, Yamaoka N, Kaneko K. Nucleosides Nucleotides Nucleic Acids. 2016 Dec;35(10-12):559-565.
5.	GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes. Nakayama A, Nakaoka H, Yamamoto K, Sakiyama M, Shaukat A, Toyoda Y, Okada Y, Kamatani Y, Nakamura T, Takada T, Inoue K, Yasujima T, Yuasa H, Shirahama Y, Nakashima H, Shimizu S, Higashino T, Kawamura Y, Ogata H, Kawaguchi M, Ohkawa Y, Danjoh I, Tokumasu A, Ooyama K, Ito T, Kondo T, Wakai K, Stiburkova B, Pavelka K, Stamp LK, Dalbeth N; Eurogout Consortium., Sakurai Y, Suzuki H, Hosoyamada M, Fujimori S, Yokoo T, Hosoya T, Inoue I, Takahashi A, Kubo M, Ooyama H, Shimizu T, Ichida K, Shinomiya N, Merriman TR, Matsuo H. Ann Rheum Dis. 2017 May;76(5):869-877.
6.	The Mechanism of False in Vitro Elevation of Uric Acid Level in Mouse Blood. Watanabe T, Tomioka NH, Watanabe S, Suzuki Y, Tsuchiya M, Hosoyamada M. Biol Pharm Bull. 2016 Jul 1;39(7):1081-4.
7.	Targeting Uric Acid and the Inhibition of Progression to End-Stage Renal Disease--A Propensity Score Analysis. Uchida S, Chang WX, Ota T, Tamura Y, Shiraishi T, Kumagai T, Shibata S, Fujigaki Y,Hosoyamada M, Kaneko K, Shen ZY, Fujimori S. PLoS One. 2015 Dec 23;10(12):e0145506.
8.	Apoptosis induced by an uromodulin mutant C112Y and its suppression by topiroxostat. Utami SB, Mahati E, Li P, Maharani N, Ikeda N, Bahrudin U, Munemura C, Hosoyamada M, Yamamoto Y, Yoshida A, Nakayama Y, Higaki K, Nanba E, Ninomiya H, Shirayoshi Y, Ichida K, Yamamoto K, Hosoya T, Hisatome I. Clin Exp Nephrol. 2014 Sep 20. [Epub ahead of print]
9.	Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures. Tomioka NH, Yasuda H, Miyamoto H, Hatayama M, Morimura N, Matsumoto Y, Suzuki T, Odagawa M, Odaka YS, Iwayama Y, Won Um J, Ko J, Inoue Y, Kaneko S, Hirose S, Yamada K, Yoshikawa T, Yamakawa K, Aruga J. Nat Commun. 2014 Jul 22;5:4501..
10.	Identification of a hypouricemia patient with SLC2A9 R380W, a pathogenic mutation for renal hypouricemia type 2. Chiba T, Matsuo H, Nagamori S, Nakayama A, Kawamura Y, Shimizu S, Sakiyama M, Hosoyamada M, Kawai S, Okada R, Hamajima N, Kanai Y, Shinomiya N. Nucleosides Nucleotides Nucleic Acids. 2014;33(4-6):261-5.
11.	False in vitro and in vivo elevations of uric acid levels in mouse blood. Watanabe T, Tomioka NH, Watanabe S, Tsuchiya M, Hosoyamada M. Nucleosides Nucleotides Nucleic Acids. 2014;33(4-6):192-8.
12.	Ependymal cells of the mouse brain express urate transporter 1 (URAT1). Tomioka NH, Nakamura M, Doshi M, Deguchi Y, Ichida K, Morisaki T, Hosoyamada M. Fluids Barriers CNS. 2013 Oct 24;10(1):31.
13.	Common dysfunctional variants in ABCG2 are a major cause of early-onset gout. Matsuo H, Ichida K, Takada T, Nakayama A, Nakashima H, Nakamura T, Kawamura Y, Takada Y, Yamamoto K, Inoue H, Oikawa Y, Naito M, Hishida A, Wakai K, Okada C, Shimizu S, Sakiyama M, Chiba T, Ogata H, Niwa K, Hosoyamada M, Mori A, Hamajima N, Suzuki H, Kanai Y, Sakurai Y, Hosoya T, Shimizu T, Shinomiya N. Sci Rep. 2013;3:2014.
14.	Macrophage migration inhibitory factor is a possible candidate for the induction of microalbuminuria in diabetic db/db mice. Watanabe T, Tomioka NH, Doshi M, Watanabe S, Tsuchiya M, Hosoyamada M. Biol Pharm Bull. 2013;36(5):741-7.
15.	Ichida K, Matsuo H, Takada T, Nakayama A, Murakami K, Shimizu T, Yamanashi Y, Kasuga H, Nakashima H, Nakamura T, Takada Y, Kawamura Y, Inoue H, Okada C, Utsumi Y, Ikebuchi Y, Ito K, Nakamura M, Shinohara Y, Hosoyamada M, Sakurai Y, Shinomiya N, Hosoya T, Suzuki H. Decreased extra-renal urate excretion is a common cause of hyperuricemia. Nat Commun. 3:764. 2012
16.	Doshi M, Takiue Y, Saito H,?Hosoyamada M. The increased protein level of URAT1 was observed in obesity/metabolic syndrome model mice. Nucleosides Nucleotides Nucleic Acids. 30(12):1290-4, 2011
17.	Yasuda M, Kaneko K, Hachisu H, Yamaoka N, Mawatari K, Nakagomi K, Minoura N, Hosoyamada M. Detection of mutant uromodulin in transgenic mouse harboring a mutant human UMOD gene. Nucleosides Nucleotides Nucleic Acids. 30(12):1284-9, 2011
18.	Sebesta I, Stiburkova B, Bartl J, Ichida K, Hosoyamada M, Taylor J, Marinaki A. Diagnostic tests for primary renal hypouricemia. Nucleosides Nucleotides Nucleic Acids. 30(12):1112-6. 2011
19.	Takiue Y, Hosoyamada M, Kimura M, Saito H. The effect of female hormones upon urate transport systems in the mouse kidney. Nucleosides Nucleotides Nucleic Acids. 30(2):113-9, 2011
20.	Takiue Y, Hosoyamada M, Kimura M, Saito H. Enhancement of Androgen Action in the Kidneys of Transgenic Mice Harboring the Mutant Human UMOD Gene. J Pharmacol Sci. 115(3):383-9, 2011
21.	Hosoyamada M, Takiue Y, Shibasaki T, Saito H: The effect of testosterone upon the urate reabsorptive transport system in mouse kidney. Nucleosides Nucleotides Nucleic Acids. 29(7):574-579, 2010
22.	Yasuda M, Kaneko K, Hachisu H, Ochiai M, Yamanobe T, Mawatari K, Nakagomi K, Minoura N, Hosoyamada M: Development of LC-MS method for detection of mutant uromodulin protein. Nucleosides Nucleotides Nucleic Acids. 29(4-6):515-7, 2010
23.	Hosoyamada M, Takiue Y, Morisaki H, Cheng J, Ikawa M, Okabe M, Morisaki T, Ichida K, Hosoya T, Shibasaki T: Establishment and analysis of SLC22A12 (URAT1) knockout mouse. Nucleosides Nucleotides Nucleic Acids. 29(4-6):314-320, 2010
24.	Nindita Y, Hamada T, Bahrudin U, Hosoyamada M, Ichida K, Iwai C, Urashima S, Kuwabara N, Utami SB, Mizuta E, Yamada K, Igawa O, Shigemasa C, Ninomiya H, Tsuchihashi T, Hisatome I: Effect of losartan and benzbromarone on the level of human urate transporter 1 mRNA. Arzneimittelforschung. 60(4):186-8, 2010
25.	Shimizu M, Khoshnoodi J, Akimoto Y, Kawakami H, Hirano H, Higashihara E, Hosoyamada M, Sekine Y, Kurayama R, Kurayama H, Joh K, Hirabayashi J, Kasai K, Tryggvason K, Ito N, Yan K: Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome. Lab Invest. 89, 178-95, 2009
26.	Hamada T, Ichida K, Hosoyamada M, Mizuta E, Yanagihara K, Sonoyama K, Sugihara S, Igawa O, Hosoya T, Ohtahara A, Shigamasa C, Yamamoto Y, Ninomiya H, Hisatome I, Uricosuric Action of Losartan via the Inhibition of Urate Transporter 1 (URAT 1) in Hypertensive Patients. Am J Hypertens 21, 1157-62, 2008
27.	Takiue Y, Hosoyamada M, Yokoo T, Kimura M, Ochiai M, Kaneko K, Ichida K, Hosoya T, Shibasaki T. Production and characterization of transgenic mice harboring mutant human UMOD gene. Nucleotides Nucleic Acids. 27, 596-600, 2008
28.	Ichida K, Hosoyamada M, Kamatani N, Kamitsuji S, Hisatome I, Shibasaki T, Hosoya T. Age and origin of the G774A mutation in SLC22A12 causing renal hypouricemia in Japanese. Clin Genet 74, 243-51, 2008
29.	Takiue Y, Hosoyamada M, Yokoo T, Kimura M, Shibasaki T: Progressive accumulation of intrinsic mouse uromodulin in the kidneys of transgenic mice harboring the mutant human uromodulin gene. Biol Pharm Bull, 31, 405-11, 2008
30.	Suzuki T, Momoi K, Hosoyamada M, Kimura M, Shibasaki T: Normal cadmium uptake in microcytic anemia mk/mk mice suggests that DMT1 is not the only cadmium transporter in vivo. Toxicol Appl Pharmacol 227, 462-7, 2008
	Publication List (Books)