Laboratory of Molecular Pharmacology
Lab page | Japanese
Publication List (Journals)
1.
 Real-time monitoring of cortical brain activity in response to acute pain using wide-area Ca2+ imaging.
Inami C, Haruta M, Ohta Y, Tanaka M, So M, Sobue K, Akay Y, Kume K, Ohta J, Akay M, Ohsawa M.
Biochem Biophys Res Commun. 2024 May 14;708:149800. doi: 10.1016/j.bbrc.2024.149800. Epub 2024 Mar 18.
2.
 Reinstating olfactory bulb-derived limbic gamma oscillations alleviates depression-like behavioral deficits in rodents.
Li Q, Takeuchi Y, Wang J, Gellert L, Barcsai L, Pedraza LK, Nagy AJ, Kozak G, Nakai S, Kato S, Kobayashi K, Ohsawa M, Horvath G, Kekesi G, L?rincz ML, Devinsky O, Buzsaki G, Berenyi A.
Neuron. 2023 Jul 5;111(13):2065-2075.e5. doi: 10.1016/j.neuron.2023.04.013. Epub 2023 May 9.
3.
 Multi-Region Microdialysis Imaging Platform Revealed Dorsal Raphe Nucleus Calcium Signaling and Serotonin Dynamics during Nociceptive Pain.
Akbar L, Castillo VCG, Olorocisimo JP, Ohta Y, Kawahara M, Takehara H, Haruta M, Tashiro H, Sasagawa K, Ohsawa M, Akay YM, Akay M, Ohta J.
Int J Mol Sci. 2023 Apr 3;24(7):6654. doi: 10.3390/ijms24076654.
4.
 Peripheral neuropathy in the pre-diabetic state of the type 2 diabetes mouse model (TSOD mice) involves TRPV1 expression in dorsal root ganglions.
Shida K, Ohsawa M, Takahashi S, Ota H, Tamura T, Kusama N, Nakasone M, Yamazaki H, Sobue K.
IBRO Neurosci Rep. 2022 Feb 8;12:163-169. doi: 10.1016/j.ibneur.2022.02.001. eCollection 2022
5.
 GI-SleepNet: A Highly Versatile Image-Based Sleep Classification Using a Deep Learning Algorithm.
Gao T, Li J, Watanabe Y, Hung C, Yamanaka A, Horie K, Yanagisawa M, Ohsawa M, Kume K.
Clocks Sleep. 2021 Nov 1;3(4):581-597. doi: 10.3390/clockssleep3040041.
6.
 Development of a neural probe integrated with high-efficiency MicroLEDs for in vivo application
Yasunaga H, Takagi T, Shinko D, Nakayama Y, Takeuchi Y, Nishikawa A, Loesing A, Ohsawa M, Sekiguchi H
2021 Jpn. J. Appl. Phys. 60 016503
7.
 Neoline, an active ingredient of the processed aconite root in Goshajinkigan formulation, targets Nav1.7 to ameliorate mechanical hyperalgesia in diabetic mice.
Nakatani Y, Negoro K, Yamauchi M, Katasho M, Ishikura KI, Iwaki A, Tsukada K, Yamaguchi M, Uehara A, Yoshida M, Ishiuchi K, Makino T, Kitajima M, Ohsawa M, Amano T.
J Ethnopharmacol. 2020 Sep 15;259:112963. doi: 10.1016/j.jep.2020.112963. Epub 2020 May 18.
8.
 Visualization of Brain Activity in a Neuropathic Pain Model Using Quantitative Activity-Dependent Manganese Magnetic Resonance Imaging.
Inami C, Tanihira H, Kikuta S, Ogasawara O, Sobue K, Kume K, Osanai M, Ohsawa M.
Front Neural Circuits. 2019 Nov 26;13:74. doi: 10.3389/fncir.2019.00074. eCollection 2019.
9.
 Involvement of l-lactate in hippocampal dysfunction of type I diabetes.
Kobayashi R, Maruoka J, Norimoto H, Ikegaya Y, Kume K, Ohsawa M.
J Pharmacol Sci. 2019 Sep;141(1):79-82. doi: 10.1016/j.jphs.2019.09.004. Epub 2019 Sep 13.
10.
 Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats.
Tanimura Y, Yoshida M, Ishiuchi K, Ohsawa M, Makino T.
J Ethnopharmacol. 2019 Sep 15;241:111859. doi: 10.1016/j.jep.2019.111859. Epub 2019 Apr 8.
11.
 Chronic brain blood-flow imaging device for a behavioral experiment using mice.
Haruta M, Kurauchi Y, Ohsawa M, Inami C, Tanaka R, Sugie K, Kimura A, Ohta Y, Noda T, Sasagawa K, Tokuda T, Katsuki H, Ohta J.
Biomed Opt Express. 2019 Mar 4;10(4):1557-1566. doi: 10.1364/BOE.10.001557. eCollection 2019 Apr 1.
12.
 Astrocyte-neuron lactate shuttle sensitizes nociceptive transmission in the spinal cord.
Miyamoto K, Ishikura KI, Kume K, Ohsawa M.
Glia. 2019 Jan;67(1):27-36. doi: 10.1002/glia.23474. Epub 2018 Nov 14.
13.
 Effect of Ninjin'yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice.
Ohsawa M, Maruoka J, Inami C, Iwaki A, Murakami T, Ishikura KI.
Front Pharmacol. 2018 Nov 30;9:1400. doi: 10.3389/fphar.2018.01400. eCollection 2018.
14.
 Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito.
Hosogi S, Ohsawa M, Kato I, Kuwahara A, Inui T, Inui A, Marunaka Y.
Front Nutr. 2018 Nov 27;5:112. doi: 10.3389/fnut.2018.00112. eCollection 2018.
15.
 N- and L-type calcium channels blocker cilnidipine ameliorates neuropathic pain.
Yamamoto S, Suzuki Y, Ono H, Kume K, Ohsawa M.
Eur J Pharmacol. 2016 Dec 15;793:66-75. doi: 10.1016/j.ejphar.2016.11.001. Epub 2016 Nov 5.
16.
 Involvement of inhibition of RhoA/Rho kinase signaling in simvastatin-induced amelioration of neuropathic pain.
Ohsawa M, Ishikura K, Mutoh J, Hisa H.
Neuroscience. 2016 Oct 1;333:204-13. doi: 10.1016/j.neuroscience.2016.07.029. Epub 2016 Jul 25.
17.
 A Retrospective Study on the Effectiveness of Switching to Oral Methadone for Relieving Severe Cancer-Related Neuropathic Pain and Limiting Adjuvant Analgesic Use in Japan.
Sugiyama Y, Sakamoto N, Ohsawa M, Onizuka M, Ishida K, Murata Y, Iio A, Sugano K, Maeno K, Takeyama H, Akechi T, Kimura K.
J Palliat Med. 2016 Oct;19(10):1051-1059. doi: 10.1089/jpm.2015.0303. Epub 2016 Jul 12.
18.
 Processed aconite root and its active ingredient neoline may alleviate oxaliplatin-induced peripheral neuropathic pain.
Suzuki T, Miyamoto K, Yokoyama N, Sugi M, Kagioka A, Kitao Y, Adachi T, Ohsawa M, Mizukami H, Makino T.
J Ethnopharmacol. 2016 Jun 20;186:44-52. doi: 10.1016/j.jep.2016.03.056. Epub 2016 Mar 30.
19.
 Involvement of renal sympathetic nerve activation on the progression of ischemic acute kidney injury in the mouse.
Mutoh J, Ohsawa M, Hisa H.
J Pharmacol Sci. 2014;125(4):415-21. doi: 10.1254/jphs.13234fp. Epub 2014 Jul 26.
20.
 Identification of the sensory nerve fiber responsible for lysophosphatidic acid-induced allodynia in mice
M Ohsawa, Y Miyabe, H Katsu, S Yamamoto, H Ono
Neuroscience. 2013 Sep 5:247:65-74. doi: 10.1016j.neuroscience.2013.05.014. Epub 2013 May 16. 
21.
 Effect of naloxone on ischemic acute kidney injury in the mouse.
Mutoh J, Ohsawa M, Hisa H.
Neuropharmacology. 2013 Aug;71:10-8. doi: 10.1016/j.neuropharm.2013.03.001. Epub 2013 Mar 19.
22.
 Mevalonate sensitizes the nociceptive transmission in the mouse spinal cord.
Ohsawa M, Mutoh J, Hisa H.
Pain. 2008 Feb;134(3):285-292. doi: 10.1016/j.pain.2007.04.031. Epub 2007 Aug 30.
23.
 KiSS-1 expression and metastin-like immunoreactivity in the rat brain.
Brailoiu GC, Dun SL, Ohsawa M, Yin D, Yang J, Chang JK, Brailoiu E, Dun NJ.
J Comp Neurol. 2005 Jan 17;481(3):314-29. doi: 10.1002/cne.20350.
24.
 Beacon/ubiquitin-like 5-immunoreactivity in the hypothalamus and pituitary of the mouse.
Brailoiu GC, Dun SL, Chi M, Ohsawa M, Chang JK, Yang J, Dun NJ.
Brain Res. 2003 Sep 12;984(1-2):215-23. doi: 10.1016/s0006-8993(03)03161-5.
25.
 Modulation of nociceptive transmission by pituitary adenylate cyclase activating polypeptide in the spinal cord of the mouse.
Ohsawa M, Brailoiu GC, Shiraki M, Dun NJ, Paul K, Tseng LF.
Pain. 2002 Nov;100(1-2):27-34. doi: 10.1016/s0304-3959(02)00207-5.
26.
 Differential antinociception induced by spinally administered endomorphin-1 and endomorphin-2 in the mouse.
Ohsawa M, Mizoguchi H, Narita M, Nagase H, Kampine JP, Tseng LF.
J Pharmacol Exp Ther. 2001 Aug;298(2):592-7.
27.
 Differential mechanisms mediating descending pain controls for antinociception induced by supraspinally administered endomorphin-1 and endomorphin-2 in the mouse.
Ohsawa M, Mizoguchi H, Narita M, Chu M, Nagase H, Tseng LF.
J Pharmacol Exp Ther. 2000 Sep;294(3):1106-11.
28.
 Role of the phosphatidylinositol-specific phospholipase C pathway in delta-opioid receptor-mediated antinociception in the mouse spinal cord.
Narita M, Ohsawa M, Mizoguchi H, Aoki T, Suzuki T, Tseng LF.
Neuroscience. 2000;99(2):327-31. doi: 10.1016/s0306-4522(00)00202-5.
29.
 Differential antinociceptive effects of endomorphin-1 and endomorphin-2 in the mouse.
Tseng LF, Narita M, Suganuma C, Mizoguchi H, Ohsawa M, Nagase H, Kampine JP.
J Pharmacol Exp Ther. 2000 Feb;292(2):576-83.
30.
 Pretreatment with protein kinase C activator phorbol 12,13-dibutyrate attenuates the antinociception induced by mu- but not epsilon-opioid receptor agonist in the mouse.
Narita M, Ohsawa M, Mizoguchi H, Kamei J, Tseng LF.
Neuroscience. 1997 Jan;76(1):291-8. doi: 10.1016/s0306-4522(96)00354-5.
31.
 Establishment and pathological characterization of type 2 diabetic mouse model produced by streptozotocin and nicotinamide.; Nakamura, T., Terajima, T., Ogata, T., Ueno, K., Hashimoto, N., Ono, K. & Yano, S.: Biol. Pharm. Bull. 29: 1167-1174, 2006.
32.
 Isolation of Gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of Gelsemium alkaloids for A431 epidermoid carcinoma cells.; Kitajima, M., Nakamura, T., Kogure, N., Ogawa, M., Mitsuno, Y., Ono, K., Yano, S., Aimi, N. & Takayama, H.: J. Natural Products 69: 715-718, 2006.
33.
 Memory and learning-enhancing effect of Daikenchuto, a traditional Japanese herbal medicine, in mice.; Nakamura, T., Komai, N., Isogami, I., Ueno, K., Ikegami, F., Ono, K. & Yano, S.: J. Nat. Med. 60: 64-67, 2006.
34.
 Elucidation of anti-allergic activities of Curcumin-related compounds with a special reference to their anti-oxidative activities.;Suzuki, M., Nakamura, T., Iyoki, S., Fujiwara, A., Watanabe, Y., Mohri, K., Isobe, K., Ono, K., & Yano, S.: Biol. Pharm. Bull. 28: 1438-1443, 2005.
35.
 Prevention of Stroke by a Japanese Traditional Medicine, Shichimotsu-koka-to, in Stroke-Prone Spontaneously Hypertensive Rats - a Histopathological Study.；Higuchi, Y., Ono, K., Onodera, H., Mitsumori, K., Sekita, S., Satake, M. & Ozaki, Y.: Natural Medicines 57: 12-17, 2003.
36.
 Elucidation with the protease α-chymotrypsin of the inhibitory modulating action of endogenous Neuropeptide Y over sympathetic neurotransmission in rat vas deferens.；Ono, K., Saito, A., Goto, K., Kasuya, Y. & Shigenoobu, K.: Journal of Pharmacological Sciences 91: 113-124, 2003.
37.
 Augmentation of the delayed rectifier potassium current by ETA endothelin receptor in guinea pig atrial myocytes.；Ono, K.: Journal of Pharmacological Sciences 91: 79-82, 2003.
38.
 Antiinflammatory effect of glycyrrhizin topically applied to the cotton pellet by granuloma porch method in rats.；Ozaki, Y. & Ono, K.: Natural Medicines 56: 261-263, 2002.
39.
 αB-Crystallin-like immunoreactivity localized at both the M- and Z-lines in isolated Syrian hamster ventricular myocytes.Ono, K., Imazawa, T. & Sakamoto, A.: Bioimages 10: 75-79, 2002.
41.
 Histological study of the accelerating effect of Shikonin and Alkannin on the proliferation of granulation tissue in rats.; Ozaki, Y., Ono, K., Sakaguchi, I. & Kato, Y.: Natural Medicines 56: 29-33, 2002.
42.
 Electrophysiological analysis of the negative chronotropic effect of endothelin-1 in rabbit sinoatrial node cells.; Ono, K., Masumiya, H., Sakamoto, A., Christ?,.G., Shijuku, T., Tanaka, H., Shigenobu, K. & Ozaki, Y.: Journal of Physiology 537: 467?488, 2001.
43.
 Histamine H2 receptor antagonism by T-593: studies on cAMP generation in Hepa cells expressing histamine H2 receptor.; Tashiro, T., Ono, K., Watanabe, T., Inoie, M., Arai, H., Kimura, S. & Kurokawa, K.: Pharmacology 59: 1-10, 1999.
44.
 Desensitization of ETA endothelin receptor-mediated negative chronotropic response in right atria - species difference and intracellular mechanisms.; Ono, K., Sakamoto, A., Masaki, T. & Satake, M.: British Journal of Pharmacology 125: 787-797,
45.
 Preventive effects of Shichimotsu-koka-to on renal lesions in stroke-prone spontaneously hypertensive rats.; Higuchi, Y., Ono, K., Sekita, S., Onodera, H., Mitsumori, K., Nara, Y. & Satake, M.: Biological and Pharmaceutical Bulletin 21: 914-918, 1998.
46.
 Both hypertrophic and dilated cardiomyopathies are caused by mutation of the same gene, δ-sarcoglycan, in hamster: an animal model of disrupted dystrophin-associated glycoprotein complex.; Sakamoto, A., Ono, K., Abe, M., Jasmin, G., Eki, T., Murakami, Y., Masaki, T., Toyo-oka, T. & Hanaoka, F.: Proceedings of the National Academy of Science (USA) 94: 13873-13878, 1997.
47.
 Truncation of the receptor carboxyl terminus impairs membrane signaling but not ligand binding of human ETB endothelin receptor.; Koshimizu, T., Tsujimoto, G., Ono, K., Masaki, T. & Sakamoto, A.: Biochemical and Biophysical Research Communications 217: 354-362, 1995.
48.
 ETA receptor-mediated modulation of calcium and potassium currents in guinea-pig and rabbit atrial myocytes.; Ono, K., Eto, K., Sakamoto, A., Masaki, T., Tsujimoto, G. & Satake, M.: Heart and Vessels Suppl. 9: 102-105, 1995.
49.
 Negative chronotropic effect of endothelin-1 mediated through ETA receptors in guinea-pig atria.; Ono, K., Eto, K., Sakamoto, A., Masaki, T., Shibata, K., Sada, T., Hashimoto, K. & Tsujimoto, G.: Circulation Research 76: 284-292, 1995.
50.
 Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents.; Ono, K., Tsujimoto, G., Sakamoto, A., Eto, K., Masaki, T., Ozaki, Y. & Satake, M.: Nature 370: 301-304, 1994.
51.
 Electrophysiological effects of calcitonin gene-related peptide in bull-frog and guinea-pig atrial myocytes.; Ono, K. & Giles, W.: Journal of Physiology 436: 195-217, 1991.
52.
 Propranolol blocks cocaine-induced potentiation of the contraction in the smooth muscle of the rat vas deferens.; Suzuki, N., Gomi, Y., Inagaki, O., Ono, K. & Kasuya, Y.: Journal of Pharmacobio-Dynamics 13: 172-178, 1990.
53.
 Calcitonin gene-related peptide regulates calcium current in heart muscle.; Ono, K., Delay, M., Nakajima, T., Irisawa, H. & Giles, W.: Nature 340: 721-724, 1989.
54.
 Modulation of the delayed rectifier K+ current by isoprenaline in bull-frog atrial myocytes.; Giles, W., Nakajima, T., Ono, K. and Shibata, E. F.: Journal of Physiology 415: 233-249, 1989.
55.
 Organ culture of young rat vas deferens as an in vitro model for the study of denervation supersensitivity.; Ono, K., Kasuya, Y. & Shigenobu, K.: European Journal of Pharmacology 117: 159-168, 1985.
Publication List (Books)