| 薬効解析学研究室 | |
| 研究室ページ | English | |
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論文リスト |
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Real-time monitoring of cortical brain activity in response to acute pain using wide-area Ca2+ imaging. Inami C, Haruta M, Ohta Y, Tanaka M, So M, Sobue K, Akay Y, Kume K, Ohta J, Akay M, Ohsawa M. Biochem Biophys Res Commun. 2024 May 14;708:149800. doi: 10.1016/j.bbrc.2024.149800. Epub 2024 Mar 18. |
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Reinstating olfactory bulb-derived limbic gamma oscillations alleviates depression-like behavioral deficits in rodents. Li Q, Takeuchi Y, Wang J, Gellert L, Barcsai L, Pedraza LK, Nagy AJ, Kozak G, Nakai S, Kato S, Kobayashi K, Ohsawa M, Horvath G, Kekesi G, L?rincz ML, Devinsky O, Buzsaki G, Berenyi A. Neuron. 2023 Jul 5;111(13):2065-2075.e5. doi: 10.1016/j.neuron.2023.04.013. Epub 2023 May 9. |
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Multi-Region Microdialysis Imaging Platform Revealed Dorsal Raphe Nucleus Calcium Signaling and Serotonin Dynamics during Nociceptive Pain. Akbar L, Castillo VCG, Olorocisimo JP, Ohta Y, Kawahara M, Takehara H, Haruta M, Tashiro H, Sasagawa K, Ohsawa M, Akay YM, Akay M, Ohta J. Int J Mol Sci. 2023 Apr 3;24(7):6654. doi: 10.3390/ijms24076654. |
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Peripheral neuropathy in the pre-diabetic state of the type 2 diabetes mouse model (TSOD mice) involves TRPV1 expression in dorsal root ganglions. Shida K, Ohsawa M, Takahashi S, Ota H, Tamura T, Kusama N, Nakasone M, Yamazaki H, Sobue K. IBRO Neurosci Rep. 2022 Feb 8;12:163-169. doi: 10.1016/j.ibneur.2022.02.001. eCollection 2022 |
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GI-SleepNet: A Highly Versatile Image-Based Sleep Classification Using a Deep Learning Algorithm. Gao T, Li J, Watanabe Y, Hung C, Yamanaka A, Horie K, Yanagisawa M, Ohsawa M, Kume K. Clocks Sleep. 2021 Nov 1;3(4):581-597. doi: 10.3390/clockssleep3040041. |
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Development of a neural probe integrated with high-efficiency MicroLEDs for in vivo application Yasunaga H, Takagi T, Shinko D, Nakayama Y, Takeuchi Y, Nishikawa A, Loesing A, Ohsawa M, Sekiguchi H 2021 Jpn. J. Appl. Phys. 60 016503 |
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Neoline, an active ingredient of the processed aconite root in Goshajinkigan formulation, targets Nav1.7 to ameliorate mechanical hyperalgesia in diabetic mice. Nakatani Y, Negoro K, Yamauchi M, Katasho M, Ishikura KI, Iwaki A, Tsukada K, Yamaguchi M, Uehara A, Yoshida M, Ishiuchi K, Makino T, Kitajima M, Ohsawa M, Amano T. J Ethnopharmacol. 2020 Sep 15;259:112963. doi: 10.1016/j.jep.2020.112963. Epub 2020 May 18. |
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Visualization of Brain Activity in a Neuropathic Pain Model Using Quantitative Activity-Dependent Manganese Magnetic Resonance Imaging. Inami C, Tanihira H, Kikuta S, Ogasawara O, Sobue K, Kume K, Osanai M, Ohsawa M. Front Neural Circuits. 2019 Nov 26;13:74. doi: 10.3389/fncir.2019.00074. eCollection 2019. |
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Involvement of l-lactate in hippocampal dysfunction of type I diabetes. Kobayashi R, Maruoka J, Norimoto H, Ikegaya Y, Kume K, Ohsawa M. J Pharmacol Sci. 2019 Sep;141(1):79-82. doi: 10.1016/j.jphs.2019.09.004. Epub 2019 Sep 13. |
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Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats. Tanimura Y, Yoshida M, Ishiuchi K, Ohsawa M, Makino T. J Ethnopharmacol. 2019 Sep 15;241:111859. doi: 10.1016/j.jep.2019.111859. Epub 2019 Apr 8. |
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Chronic brain blood-flow imaging device for a behavioral experiment using mice. Haruta M, Kurauchi Y, Ohsawa M, Inami C, Tanaka R, Sugie K, Kimura A, Ohta Y, Noda T, Sasagawa K, Tokuda T, Katsuki H, Ohta J. Biomed Opt Express. 2019 Mar 4;10(4):1557-1566. doi: 10.1364/BOE.10.001557. eCollection 2019 Apr 1. |
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Astrocyte-neuron lactate shuttle sensitizes nociceptive transmission in the spinal cord. Miyamoto K, Ishikura KI, Kume K, Ohsawa M. Glia. 2019 Jan;67(1):27-36. doi: 10.1002/glia.23474. Epub 2018 Nov 14. |
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Effect of Ninjin'yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice. Ohsawa M, Maruoka J, Inami C, Iwaki A, Murakami T, Ishikura KI. Front Pharmacol. 2018 Nov 30;9:1400. doi: 10.3389/fphar.2018.01400. eCollection 2018. |
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Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito. Hosogi S, Ohsawa M, Kato I, Kuwahara A, Inui T, Inui A, Marunaka Y. Front Nutr. 2018 Nov 27;5:112. doi: 10.3389/fnut.2018.00112. eCollection 2018. |
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N- and L-type calcium channels blocker cilnidipine ameliorates neuropathic pain. Yamamoto S, Suzuki Y, Ono H, Kume K, Ohsawa M. Eur J Pharmacol. 2016 Dec 15;793:66-75. doi: 10.1016/j.ejphar.2016.11.001. Epub 2016 Nov 5. |
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Involvement of inhibition of RhoA/Rho kinase signaling in simvastatin-induced amelioration of neuropathic pain. Ohsawa M, Ishikura K, Mutoh J, Hisa H. Neuroscience. 2016 Oct 1;333:204-13. doi: 10.1016/j.neuroscience.2016.07.029. Epub 2016 Jul 25. |
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A Retrospective Study on the Effectiveness of Switching to Oral Methadone for Relieving Severe Cancer-Related Neuropathic Pain and Limiting Adjuvant Analgesic Use in Japan. Sugiyama Y, Sakamoto N, Ohsawa M, Onizuka M, Ishida K, Murata Y, Iio A, Sugano K, Maeno K, Takeyama H, Akechi T, Kimura K. J Palliat Med. 2016 Oct;19(10):1051-1059. doi: 10.1089/jpm.2015.0303. Epub 2016 Jul 12. |
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Processed aconite root and its active ingredient neoline may alleviate oxaliplatin-induced peripheral neuropathic pain. Suzuki T, Miyamoto K, Yokoyama N, Sugi M, Kagioka A, Kitao Y, Adachi T, Ohsawa M, Mizukami H, Makino T. J Ethnopharmacol. 2016 Jun 20;186:44-52. doi: 10.1016/j.jep.2016.03.056. Epub 2016 Mar 30. |
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Involvement of renal sympathetic nerve activation on the progression of ischemic acute kidney injury in the mouse. Mutoh J, Ohsawa M, Hisa H. J Pharmacol Sci. 2014;125(4):415-21. doi: 10.1254/jphs.13234fp. Epub 2014 Jul 26. |
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Identification of the sensory nerve fiber responsible for lysophosphatidic acid-induced allodynia in mice M Ohsawa, Y Miyabe, H Katsu, S Yamamoto, H Ono Neuroscience. 2013 Sep 5:247:65-74. doi: 10.1016j.neuroscience.2013.05.014. Epub 2013 May 16. |
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Effect of naloxone on ischemic acute kidney injury in the mouse. Mutoh J, Ohsawa M, Hisa H. Neuropharmacology. 2013 Aug;71:10-8. doi: 10.1016/j.neuropharm.2013.03.001. Epub 2013 Mar 19. |
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Mevalonate sensitizes the nociceptive transmission in the mouse spinal cord. Ohsawa M, Mutoh J, Hisa H. Pain. 2008 Feb;134(3):285-292. doi: 10.1016/j.pain.2007.04.031. Epub 2007 Aug 30. |
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KiSS-1 expression and metastin-like immunoreactivity in the rat brain. Brailoiu GC, Dun SL, Ohsawa M, Yin D, Yang J, Chang JK, Brailoiu E, Dun NJ. J Comp Neurol. 2005 Jan 17;481(3):314-29. doi: 10.1002/cne.20350. |
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Beacon/ubiquitin-like 5-immunoreactivity in the hypothalamus and pituitary of the mouse. Brailoiu GC, Dun SL, Chi M, Ohsawa M, Chang JK, Yang J, Dun NJ. Brain Res. 2003 Sep 12;984(1-2):215-23. doi: 10.1016/s0006-8993(03)03161-5. |
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Modulation of nociceptive transmission by pituitary adenylate cyclase activating polypeptide in the spinal cord of the mouse. Ohsawa M, Brailoiu GC, Shiraki M, Dun NJ, Paul K, Tseng LF. Pain. 2002 Nov;100(1-2):27-34. doi: 10.1016/s0304-3959(02)00207-5. |
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Differential antinociception induced by spinally administered endomorphin-1 and endomorphin-2 in the mouse. Ohsawa M, Mizoguchi H, Narita M, Nagase H, Kampine JP, Tseng LF. J Pharmacol Exp Ther. 2001 Aug;298(2):592-7. |
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Differential mechanisms mediating descending pain controls for antinociception induced by supraspinally administered endomorphin-1 and endomorphin-2 in the mouse. Ohsawa M, Mizoguchi H, Narita M, Chu M, Nagase H, Tseng LF. J Pharmacol Exp Ther. 2000 Sep;294(3):1106-11. |
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Role of the phosphatidylinositol-specific phospholipase C pathway in delta-opioid receptor-mediated antinociception in the mouse spinal cord. Narita M, Ohsawa M, Mizoguchi H, Aoki T, Suzuki T, Tseng LF. Neuroscience. 2000;99(2):327-31. doi: 10.1016/s0306-4522(00)00202-5. |
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Differential antinociceptive effects of endomorphin-1 and endomorphin-2 in the mouse. Tseng LF, Narita M, Suganuma C, Mizoguchi H, Ohsawa M, Nagase H, Kampine JP. J Pharmacol Exp Ther. 2000 Feb;292(2):576-83. |
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Pretreatment with protein kinase C activator phorbol 12,13-dibutyrate attenuates the antinociception induced by mu- but not epsilon-opioid receptor agonist in the mouse. Narita M, Ohsawa M, Mizoguchi H, Kamei J, Tseng LF. Neuroscience. 1997 Jan;76(1):291-8. doi: 10.1016/s0306-4522(96)00354-5. |
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末吉祥子、丹野雅幸、平野恵子、宮田直樹、小野景義、佐竹元吉：一酸化窒素(NO)発生剤の研究(II) --- Biotransformationモデル化合物の合成とNO発生および平滑筋弛緩作用 磁気共鳴と医学 7: 230-232, 1996. |
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小野景義、粕谷豊、重信弘毅、斉藤亜紀良、後藤勝年： Neuropeptide Y (NPY)のラット輸精管における交感神経伝達における生理的役割について。 日本平滑筋学会雑誌 22: 325-327, 1987. |
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小野景義、重信弘毅、粕谷豊： ラット輸精管の器官培養 --- IV. 神経のextractによるpostjunctional supersensitivityの発現の抑制。 日本平滑筋学会雑誌 21: 311-313, 1986. |
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著書リスト・その他 |
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1.
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小野景義： 薬物拮抗薬・重金属中毒治療薬（分担）、「薬剤師のための常用医薬品情報集」pp. 935-949、2006、廣川書店 |
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2.
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小野景義：高血圧治療薬（分担）、「薬理学―医薬品の作用」竹内幸一、福井裕行、 栗原順一 編 pp. 272-283、2005、廣川書店 |
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3.
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小野景義： 薬物拮抗薬・重金属中毒治療薬（分担）、「薬剤師のための常用医薬品情報集」pp. 1037-1049、2002、廣川書店 |
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4.
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小野景義： Na+ チャネルと薬理、「医系薬理学」遠藤仁、橋本敬太郎、後藤勝年 編著、pp. 53-62、1997、 中外医学社 |
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5.
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小野景義： 単離心筋細胞を用いた膜電流測定法、「生物薬科学実験講座」第14巻 臓器機能測定法 II、岡部進 編著、pp. 277-311、1992、廣川書店 |
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6.
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小野景義： patch clamp法による単離心筋細胞の膜電流測定法、「生物薬科学実験講座」第14巻 臓器機能測定法 II、岡部進 編著、pp. 311-412、1992、廣川書店 |
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7.
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小野景義： パッチクランプ法、ファルマシア 37: 133-135, 2001. |
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8.
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小野景義： エンドセリンの新しい心臓調節作用―電気生理学的知見を中心に― ヒューマンサイエンス 6 (5): 22-25, 1995. (財)ヒューマンサイエンス振興財団 |
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