Faculty of Pharma Sciences, Teikyo University Lab page | Japanese
Laboratory of Biomedical and Analytical Sciences

Publication List (Journals)
1.
Comprehensive study of metabolic changes induced by a ketogenic diet therapy using GC/MS- and LC/MS-based metabolomics; Akiyama M, Akiyama T, Saigusa D, Hishinuma E, Matsukawa N, Shibata T, Tsuchiya H, Mori A, Fujii Y, Mogami Y, Tokorodani C, Kuwahara K, Numata-Uematsu Y, Inoue K, Kobayashi K; Seizure., 107:52-59 (2023)
2.
Decreased -hydroxybutyrate and ketogenic amino acid levels in depressed human adults; Sato S, Yu Z, Sakai M, Motoike IN, Saigusa D, Hirayama R, Kikuchi Y, Abe T, Kinoshita K, Koshiba S, Tomita H; Eur J Neurosci., 57(6):1018-1032 (2023)
3.
Modulations of bioactive lipids and their receptors in postmortem Alzheimer's disease brains; Kurano M, Saito Y, Uranbileg B, Saigusa D, Kano K, Aoki J, Yatomi Y; Front Aging Neurosci., 9;14:1066578 (2022)
4.
Quantification of threonine-containing lysophospholipids using ESI-LC-MS/MS in mouse tissues; Okudaira M, Kano K, Makide K, Saigusa D, Ohwada T, Aoki J; Medical Mass Spectrometry., 6(2): 138-148 (2022)
5.
Lipidomic and metabolic profiling of plasma and plasma-derived extracellular vesicles by UHPLC-MS/MS; Saigusa D, Honda T, Iwasaki Y, Ueda K, Hishinuma E, Matsukawa N, Togashi A, Matsutani N, Seki N; Medical Mass Spectrometry., 6(2): 126-137 (2022)
6.
Dynamic modulations of urinary sphingolipid and glycerophospholipid levels in COVID-19 and correlations with COVID-19-associated kidney injuries; Kurano M, Jubishi D, Okamoto K, Hashimoto H, Sakai E, Morita Y, Saigusa D, Kano K, Aoki J, Harada S, Okugawa S, Doi K, Moriya K, Yatomi Y; J Biomed Sci., 10;29(1):94 (2022)
7.
Plasma metabolic disturbances during pregnancy and postpartum in women with depression; Yu Z, Matsukawa N, Saigusa D, Motoike IN, Ono C, Okamura Y, Onuma T, Takahashi Y, Sakai M, Kudo H, Obara T, Murakami K, Shirota M, Kikuchi S, Kobayashi N, Kikuchi Y, Sugawara J, Minegishi N, Ogishima S, Kinoshita K, Yamamoto M, Yaegashi N, Kuriyama S, Koshiba S, Tomita H; iScience., 25(12):105666 (2022)
8.
Analytical evaluation of fatty acid esters of hydroxy fatty acid quantity in fermented brown rice and rice bran (FRBA); Watanabe A, Balas L, Saigusa D, Ogura J, Durand T, Mano N, Yamaguchi H; Food Chemistry Advances., 1:100040 (2022)
9.
Dynamic modulations of sphingolipids and glycerophospholipids in COVID-19; Kurano M, Okamoto K, Jubishi D, Hashimoto H, Sakai E, Saigusa D, Kano K, Aoki J, Harada S, Okugawa S, Doi K, Moriya K, Yatomi Y; Clin Transl Med., 12(10):e1069 (2022)
10.
Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice; Liu Y, Uruno A, Saito R, Matsukawa N, Hishinuma E, Saigusa D, Liu H, Yamamoto M; Redox Biol., 58:102525 (2022)
11.
Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment; Tatara Y, Yamazaki H, Katsuoka F, Chiba M, Saigusa D, Kasai S, Nakamura T, Inoue J, Aoki Y, Shoji M, Motoike IN, Tamada Y, Hashizume K, Shoji M, Kinoshita K, Murashita K, Nakaji S, Yamamoto M, Itoh K; Curr Res Transl Med., 71(1):103367.(2023)
12.
Metabolic and Epigenetic Regulation of SMAD7 by STC1 Ameliorates Lung Fibrosis; Ohkouchi S, Kanehira M, Saigusa D, Ono M, Tazawa R, Terunuma H, Hirano T, Numakura T, Notsuda H, Inoue C, Saito-Koyama R, Tabata M, Irokawa T, Ogawa H, Kurosawa H, Okada Y; Am J Respir Cell Mol Biol., 67(3):320-333 (2022)
13.
Introducing the Lipidomics Minimal Reporting Checklist; McDonald JG, Ejsing CS, Kopczynski D, Hol?apek M, Aoki J, Arita M, Arita M, Baker ES, Bertrand-Michel J, Bowden JA, Brugger B, Ellis SR, Fedorova M, Griffiths WJ, Han X, Hartler J, Hoffmann N, Koelmel JP, Kofeler HC, Mitchell TW, O'Donnell VB, Saigusa D, Schwudke D, Shevchenko A, Ulmer CZ, Wenk MR, Witting M, Wolrab D, Xia Y, Ahrends R, Liebisch G, Ekroos K; Nat Metab., 4(9):1086-1088 (2022) 
14.
Codon Usage and mRNA Stability are Translational Determinants of Cellular Response to Canonical Ferroptosis Inducers; Rashad S, Byrne SR, Saigusa D, Xiang J, Zhou Y, Zhang L, Begley TJ, Tominaga T, Niizuma K; Neuroscience., 1;501:103-130 (2022)
15.
Purine content of hospital meals and its effect on serum uric acid, urine pH, and urinary uric acid excretion; Takayanagi F, Uchino T, Motoki N, Uchida K, Asakura H, Uno-Eder K, Nomura T, Tsukamoto K, Fukuuchi T, Yamaoka N, Kaneko K; Nucleosides Nucleotides Nucleic Acids.,41(12):1296-1304 (2022)
16.
Determination of total purine and free purine content in milk, soymilk, and enteral nutritional supplements to assist nutritional therapy for hyperuricemia and gout; Fukuuchi T, Itahashi I, Takayanagi F, Yamaoka N, Kaneko K; Nucleosides Nucleotides Nucleic Acids., 41(12):1287-1295 (2022)
17.
Xanthinuria Type 1 with a Novel Mutation in Xanthine Dehydrogenase and a Normal Endothelial Function; Miyazaki S, Hamada T, Sugihara S, Mizuta E, Endo Y, Ohtahara A, Komatsu K, Kuwabara M, Fukuuchi T, Kaneko K, Ichida K, Ogino K, Ninomiya H, Yamamoto K, Nakamura T, Hisatome I; Intern Med., 61(9):1383-1386 (2022)
18.
Lysophosphatidic acid receptor1/3 antagonist inhibits the activation of satellite glial cells and reduces acute nociceptive responses; Hoshino Y, Okuno T, Saigusa D, Kano K, Yamamoto S, Shindou H, Aoki J, Uchida K, Yokomizo T, Ito N; FASEB J., 36(4):e22236 (2022)
19.
Urine autotaxin levels reflect the disease activity of sarcoidosis; Murakami K, Tamada T, Saigusa D, Miyauchi E, Nara M, Ichinose M, Kurano M, Yatomi Y, Sugiura H; Sci Rep., 14;12(1):4372 (2022)
20.
Increased Lung Uric Acid Deteriorates Pulmonary Arterial Hypertension; Watanabe T, Ishikawa M, Abe K, Ishikawa T, Imakiire S, Masaki K, Hosokawa K, Fukuuchi T, Kaneko K, Ohtsubo T, Hirano M, Hirano K, Tsutsui H; J Am Heart Assoc., 7;10(23):e022712 (2021)
21.
Effects of islatravir (4'-ethynyl-2-fluoro-2'-deoxyadenosine or EFdA) on renal tubular cells and islatravir's interactions with organic anion transporters; Kaneko M, Reien Y, Morio H, Fukuuchi T, Kaneko K, Hirayama Y, Hashimoto H, Kuwata N, Mitsuya H, Anzai N; J Pharmacol Sci., 146(2):82-87 (2021)
22.
Measurement of the total purine contents and free nucleosides, nucleotides, and purine bases composition in Japanese anchovies (Engraulis japonicus) using high-performance liquid chromatography with UV detection; Takayanagi F, Fukuuchi T, Yamaoka N, Kaneko K; Nucleosides Nucleotides Nucleic Acids.,39(10-12):1458-1464.(2020)
23.
Differentiation of Positional Isomers of Halogenated Benzoylindole Synthetic Cannabinoid Derivatives in Serum by Hybrid Quadrupole/Orbitrap Mass Spectrometry.@Fukuuchi T, Moriya SS, Sugiyama T, Tabata H, Kaneko K.Anal Sci. 10;37(2):329-335, 2021
24.
Measurement of the total purine contents and free nucleosides, nucleotides, and purine bases composition in Japanese anchovies (Engraulis japonicus) using high-performance liquid chromatography with UV detection.Takayanagi F, Fukuuchi T, Yamaoka N, Kaneko K. Nucleosides Nucleotides Nucleic Acids. 39(10-12):1458-1464, 2020
25.
Determination of total purine and purine base content of 80 food products to aid nutritional therapy for gout and hyperuricemia.Kaneko K, Takayanagi F, Fukuuchi T, Yamaoka N, Yasuda M, Mawatari KI, Fujimori S. Nucleosides Nucleotides Nucleic Acids.39(10-12):1449-1457, 2020
26.
Species-dependent patterns of incorporation of purine mononucleotides and nucleosides by lactic acid bacteria. Kano H, Saito C, Yamada N, Fukuuchi T, Yamaoka N, Kaneko K, Asami Y. Nucleosides Nucleotides Nucleic Acids. 39(10-12):1440-1448, 2020
27.
Lactobacillus gasseri PA-3 directly incorporates purine mononucleotides and utilizes them for growth.Yamada N, Saito C, Kano H, Fukuuchi T, Yamaoka N, Kaneko K, Asami Y.Nucleic Acids. 20:1-10, 2020
28.
Lactic Acid Bacteria Show Different Patterns of Incorporation of Purine Mononucleotides and Nucleosides Depending on the Species. H. Kano, C. Saito, N. Yamada, T. Fukuuchi, N. Yamaoka and K. Kaneko. Nucleosides Nucleotides Nucleic Acids. 39(10-12):1440-1448, 2020
29.
Lactobacillus Gasseri PA-3 Incorporates Purine Mononucleotides and Utilizes Them for RNA/DNA Synthesis. N. Yamada, C. Saito, H. Kano, Y. Fukuuchi, N. Yamaoka, K. Kaneko, and Y. Asami. Nucleosides Nucleotides Nucleic Acids. 20;1-10. 2020
30.
Determination of Total Purine and Purine Base Content of 80 Food products to Aid Nutritional Therapy for Gout and Hyperuricemia.. K. Kaneko, F. Takayanagi, T. Fukuuchi, N. Yamaoka, S. Fujimori, Nucleosides Nucleotides Nucleic Acids. 2020 Apr 20:1-9. doi: 10.1080/15257770.2020.1748197.
31.
Determination of Dipicolinic Acid in "Natto" by High Performance Liquid Chromatography Coupled with Postcolumn Photoirradiation with Zinc Acetate. Mawatari KI, Atsumi M, Nakamura F, Yasuda M, Fukuuchi T, Yamaoka N, Kaneko K, Nakagomi K, Oku N. Int J Tryptophan Res. 2019 Jun 19;12:1178646919852120. doi: 10.1177/1178646919852120. eCollection 2019.
32.
Simultaneous Determination of Kynurenine and Kynurenic Acid by High-Performance Liquid Chromatography Photoirradiation System Using a Mobile Phase Containing 18-crown-6. Atsumi M, Mawatari KI, Morooka A, Yasuda M, Fukuuchi T, Yamaoka N, Kaneko K, Nakagomi K, Oku N. Int J Tryptophan Res. 2019 Mar 14;12:1178646919834551. doi: 10.1177/1178646919834551. eCollection 2019.
33.
Sensitive Analysis of Sialic Acid and Related Compound by Hydrophilic Interaction Liquid Chromatography Using Fluorescence Detection after Derivatization with DBD-PZ. A.Kawasaki, M.Yasuda, K.Mawatari, T.Fukuuchi, N.Yamaoka, K.Kaneko, R.Iijima, S.Yui, M.Satoh and K.Nakagomi. Anal. Sci. 34: 841-844, 2018
34.
Change in the Purine Composition of Food by Soaking in Sake Lees. Takayanagi F, Fukuuchi T, Yamaoka N, Kaneko K. Nucleosides, Nucleotides and Nucleic Acids 37 (5): 273-279, 2018
35.
Measurement of Purine Content in Umami Soup And Evaluation of its Effects on Extra- And Intracellular Purine Metabolism Using HPLC Simultaneous Determination. Fukuuchi T, Iyama N, Yamaoka N, Kaneko K. Nucleosides, Nucleotides and Nucleic Acids 37(6): 348-352, 2018
36.
Proteomic Analysis of A Urinary Stone with Two Layers Composed of Calcium Oxalate Monohydrate and Uric Acid. Kaneko K, Kabeya M, Kondo H, Fukuuchi T, Yamaoka N, Yasuda M, .Yamagichi S. Nucleosides, Nucleotides and Nucleic Acids: https://doi.org/10.1080/15257770.2018.1478095.
37.
Clinical studies on changes in purine compounds in blood and urine by the simultaneous administration of febuxostat and inosine, or by single administration of each. Kamatani N, Hashimoto M, Sakurai K, Gokita K, Yoshihara J, Sekine M, Mochii M, Fukuuchi T, Yamaoka N, and Kaneko K. Gout and Nucleic Acid Metabolism 141 (2): 171-181, 2017
38.
Evaluation of cellular purine transport and metabolism in the Caco-2 cell using comprehensive high-performance liquid chromatography method for analysis of purines. Fukuuchi, T.,Kobayashi, M.,Yamaoka, N.,Kaneko, K.. Nucleosides, Nucleotides and Nucleic Acids 35(10-12): 663-669@2016
39.
Analysis of l-DOPA-derived melanin and a novel degradation product formed under alkaline conditions. Hidetoshi Omotani, Makoto Yasuda, Ritsuko Ishii, Tsukasa Ikarashi, Tomoko Fukuuchi, Noriko Yamaoka, Ken-ichi Mawatari, Kiyoko Kaneko, Kazuya Nakagomi. Journal of Pharmaceutical and Biomedical Analysis. 125: 22-26, 2016.
40.

.
Urinary excretion of uric acid, allantoin, and 8-OH-deoxyguanosine in uricase-knockout mice. K. Inazawa, S. Yamaguchi, M. Hosoyamada, T. Fukuuchi, N. H. Tomioka, N. Yamaoka, and K. Kaneko. Nucleosides, Nucleotides and Nucleic Acids. 35(10-12): 559-565, 2016
41.
Evaluation of purine utilization by Lactobacillus gasseri strains with potential to decrease the absorption of food-derived purines in the human intestine. N. Yamada, C. Iwamoto, H. Kano, N. Yamaoka, T. Fukuuchi, K. Kaneko, and Y. Asami. Nucleosides, Nucleotides and Nucleic Acids. 35(10-12): 670-676, 2016
42.
Proteomic Analysis after Sequential Extraction of Matrix Proteins in Urinary Stones Composed of Calcium Oxalate Monohydrate and Calcium Oxalate Dihydrate. Kiyoko Kaneko, Shin-ichiro Nishii, Yoko Izumi, Makoto Yasuda, Tomoyo Yamanobe, Tomoko Fukuuchi, Noriko Yamaoka, and Shigeo Horie. Ana Sci 31(9): 935-942, 2015
43.
Analysis of Intra- and Extracellular Levels of Purine Bases, Nucleosides, and Nucleotides in HepG2 cells by High-performance Liquid Chromatography. Tomoko Fukuuchi, Noriko Yamaoka, and Kiyoko Kaneko. Ana Sci 31(9): 895-901, 2015
44.
Total purine content and comparison of the ratio of purine bases in common foodstuffs. Kiyoko Kaneko, Tomoko Fukuuchi, Katsunori Inazawa, Noriko Yamaoka, Shin Fujimori. Gout and Nucleic Acid Metabolism 39(1): 7-21, 2015.
45.
Characterizing substrate properties of purine-related compounds with purine metabolism enzymes for enzymatic peak-shift HPLC method. Fukuuchi T, Morimura A, Kawatani M, Yamamoto K, Yamaoka N, Kaneko K. Nucleosides Nucleotides Nucleic Acids., 33(4-6), 445-453. 2014
46.
Determination and profiling of purines in foods by using HPLC and LC-MS. Inazawa K, Sato A, Kato Y, Yamaoka N, Fukuuchi T, Yasuda M, Mawatari K, Nakagomi K, and Kaneko K. Nucleosides Nucleotides Nucleic Acids., 33(4-6), 439-444.2014
47.
Development of a fluorescence analysis method for N-acetylneuraminic acid and its oxidized product ADOA. Ota T, Yasuda M, Iijima R, Yui S, Mawatari K, Fukuuchi T, Yamaoka N, Kaneko K, Nakagomi K. Journal of Chromatography B, 932: 152-157, 2013
48.
Simultaneous determination of nicotine and cotinine in serum using high-performance liquid chromatography with fluorometric detection and postcolumn UV-photoirradiation system. Yasuda M, Ota T, Morikawa A, Mawatari K, Fukuuchi T, Yamaoka N, Kaneko K, Nakagomi K Journal of Chromatography B, 934: 41-45, 2013..
49.
Proteomic analysis of a rare urinary stone composed of calcium carbonate and calcium oxalate dihydrate: A case report. Kaneko K, Matsuta Y, Moriyama M, YasudaM, ChishimaN, Yamaoka N, Fukuuchi T, Miyazawa K, and Suzuki K. Int J Urol, 21: 341-346, 2014. (doi: 10.1111/iju.12282, 2013)
50.
A simple HPLC method for determining the purine content of beer and beer-like alcoholic beverages. Fukuuchi T, Yasuda M, Inazawa K, Ota T,Yamaoka N, Mawatari K, Nakagomi K, and Kaneko K. Analytical Sciences, 29: 511-517, 2013
51.
Enhancing Effect of Aged Garlic Extract on Induction of Morphological Differentiation with Neurite Outgrowth in NGF-treated PC12 Cells. Kohda K., Itoh K., Goda H., Samejima K., Fukuuchi T., Morihara N., Imamura K., Kodera Y., Oka T.; Pharmacology & Pharmacy, 3: 37-43, 2012
52.
Simultaneous determination of purine and pyrimidine metabolites in HPRT-deficient cell lines. Yamaoka N, Inazawa K, Inagawa S, Fujimori S., Yasuda M., Mawatari K., Nakagomi K., Yamada Y., and Kaneko K.; Nucleosides Nucleotides Nucleic Acids, 30 (12): 1256-1259, 2011
53.
Profiling of purines in four kinds of mushroom with the use of HPLC and LC-MS. Inazawa K., Yamaoka N., Inagawa S., Yasuda M., Mawatari K., Nakagomi K., Hisatome .I, Kaneko K.; (Abstract in English) Gout and Nucleic Acid Metabolism, 35 (2): 175-181, 2011.
54.
Urinary stone analysis in a patient with hyperuricemia to determine the mechanism of stone formation. Kaneko K, Yoshida N, Okazaki K, Yamanobe T, Yamaoka N, Yasuda M, Ogata N, Yamada Y, Uchida S, Fujimori S; Nucleosides Nucleotides Nucleic Acids, 30 (12): 1272-1276, 2011
55.
Detection of mutant uromodulin in transgenic mouse harboring a mutant human UMOD gene. Yasuda M, Kaneko K, Hachisu H, Yamaoka N, Mawatari K, Nakagomi K, Minoura N, Hosoyamada M; Nucleosides Nucleotides Nucleic Acids, 30 (12): 1284-1289, 2011
56.
Molecular analysis of X-Linked inborn errors of purine metabolism: HPRT1 and PRPS1 mutations. Yamada.Y., YamadaK., Nomura N., Yamano A, Kimura R., Naiki M., Fukushi., Wakamatsu N., Taniguchi A., Yamaoka N., Kaneko K., Fujimori S.; Nucleosides Nucleotides Nucleic Acids, 30 (12): 1272-1275, 2011
57.
Novel pathway of metabolic activation of bisphenol A-related compounds for estrogenic activity.Okuda K., Fukuuchi T., Takiguchi M., Yoshihara S.; Drug metabolism and disposition, 39(9): 1696-1703,2011
58.
Simultaneous determination of nucleosides and nucleotides in dietary foods and beverages using ion-pairing liquid chromatography-electrospray ionization-mass spectrometry. Yamaoka N., Kudo Y., Inazawa K., Inagawa S., Yasuda M., Mawatari K., Nakagomi K., and Kaneko K.; J Chromatography B, 878: 2054-2060, 2010
59.
Analysis of purine in purine-rich cauliflower. Yamaoka N., Kaneko K., Kudo Y., Aoki M., Yasuda M., Mawatari K., Nakagomi K., Y Yamada Y., and Yamamoto T.; Nucleosides, Nucleotides and Nucleic Acids, 29: 518-521, 2010
Publication List (Books and others)