帝京大学薬学部 研究室ページ | English
臨床分析学研究室

論文リスト
1.
Comprehensive study of metabolic changes induced by a ketogenic diet therapy using GC/MS- and LC/MS-based metabolomics; Akiyama M, Akiyama T, Saigusa D, Hishinuma E, Matsukawa N, Shibata T, Tsuchiya H, Mori A, Fujii Y, Mogami Y, Tokorodani C, Kuwahara K, Numata-Uematsu Y, Inoue K, Kobayashi K; Seizure., 107:52-59 (2023)
2.
Decreased β-hydroxybutyrate and ketogenic amino acid levels in depressed human adults; Sato S, Yu Z, Sakai M, Motoike IN, Saigusa D, Hirayama R, Kikuchi Y, Abe T, Kinoshita K, Koshiba S, Tomita H; Eur J Neurosci., 57(6):1018-1032 (2023)
3.
Modulations of bioactive lipids and their receptors in postmortem Alzheimer's disease brains; Kurano M, Saito Y, Uranbileg B, Saigusa D, Kano K, Aoki J, Yatomi Y; Front Aging Neurosci., 9;14:1066578 (2022)
4.
Quantification of threonine-containing lysophospholipids using ESI-LC-MS/MS in mouse tissues; Okudaira M, Kano K, Makide K, Saigusa D, Ohwada T, Aoki J; Medical Mass Spectrometry., 6(2): 138-148 (2022)
5.
Lipidomic and metabolic profiling of plasma and plasma-derived extracellular vesicles by UHPLC-MS/MS; Saigusa D, Honda T, Iwasaki Y, Ueda K, Hishinuma E, Matsukawa N, Togashi A, Matsutani N, Seki N; Medical Mass Spectrometry., 6(2): 126-137 (2022)
6.
Dynamic modulations of urinary sphingolipid and glycerophospholipid levels in COVID-19 and correlations with COVID-19-associated kidney injuries; Kurano M, Jubishi D, Okamoto K, Hashimoto H, Sakai E, Morita Y, Saigusa D, Kano K, Aoki J, Harada S, Okugawa S, Doi K, Moriya K, Yatomi Y; J Biomed Sci., 10;29(1):94 (2022)
7.
Plasma metabolic disturbances during pregnancy and postpartum in women with depression; Yu Z, Matsukawa N, Saigusa D, Motoike IN, Ono C, Okamura Y, Onuma T, Takahashi Y, Sakai M, Kudo H, Obara T, Murakami K, Shirota M, Kikuchi S, Kobayashi N, Kikuchi Y, Sugawara J, Minegishi N, Ogishima S, Kinoshita K, Yamamoto M, Yaegashi N, Kuriyama S, Koshiba S, Tomita H; iScience., 25(12):105666 (2022)
8.
Analytical evaluation of fatty acid esters of hydroxy fatty acid quantity in fermented brown rice and rice bran (FRBA); Watanabe A, Balas L, Saigusa D, Ogura J, Durand T, Mano N, Yamaguchi H; Food Chemistry Advances., 1:100040 (2022)
9.
Dynamic modulations of sphingolipids and glycerophospholipids in COVID-19; Kurano M, Okamoto K, Jubishi D, Hashimoto H, Sakai E, Saigusa D, Kano K, Aoki J, Harada S, Okugawa S, Doi K, Moriya K, Yatomi Y; Clin Transl Med., 12(10):e1069 (2022)
10.
Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice; Liu Y, Uruno A, Saito R, Matsukawa N, Hishinuma E, Saigusa D, Liu H, Yamamoto M; Redox Biol., 58:102525 (2022)
11.
Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment; Tatara Y, Yamazaki H, Katsuoka F, Chiba M, Saigusa D, Kasai S, Nakamura T, Inoue J, Aoki Y, Shoji M, Motoike IN, Tamada Y, Hashizume K, Shoji M, Kinoshita K, Murashita K, Nakaji S, Yamamoto M, Itoh K; Curr Res Transl Med., 71(1):103367.(2023)
12.
Metabolic and Epigenetic Regulation of SMAD7 by STC1 Ameliorates Lung Fibrosis; Ohkouchi S, Kanehira M, Saigusa D, Ono M, Tazawa R, Terunuma H, Hirano T, Numakura T, Notsuda H, Inoue C, Saito-Koyama R, Tabata M, Irokawa T, Ogawa H, Kurosawa H, Okada Y; Am J Respir Cell Mol Biol., 67(3):320-333 (2022)
13.
Introducing the Lipidomics Minimal Reporting Checklist; McDonald JG, Ejsing CS, Kopczynski D, Hol?apek M, Aoki J, Arita M, Arita M, Baker ES, Bertrand-Michel J, Bowden JA, Brugger B, Ellis SR, Fedorova M, Griffiths WJ, Han X, Hartler J, Hoffmann N, Koelmel JP, Kofeler HC, Mitchell TW, O'Donnell VB, Saigusa D, Schwudke D, Shevchenko A, Ulmer CZ, Wenk MR, Witting M, Wolrab D, Xia Y, Ahrends R, Liebisch G, Ekroos K; Nat Metab., 4(9):1086-1088 (2022) 
14.
Codon Usage and mRNA Stability are Translational Determinants of Cellular Response to Canonical Ferroptosis Inducers; Rashad S, Byrne SR, Saigusa D, Xiang J, Zhou Y, Zhang L, Begley TJ, Tominaga T, Niizuma K; Neuroscience., 1;501:103-130 (2022)
15.
Purine content of hospital meals and its effect on serum uric acid, urine pH, and urinary uric acid excretion; Takayanagi F, Uchino T, Motoki N, Uchida K, Asakura H, Uno-Eder K, Nomura T, Tsukamoto K, Fukuuchi T, Yamaoka N, Kaneko K; Nucleosides Nucleotides Nucleic Acids.,41(12):1296-1304 (2022)
16.
Determination of total purine and free purine content in milk, soymilk, and enteral nutritional supplements to assist nutritional therapy for hyperuricemia and gout; Fukuuchi T, Itahashi I, Takayanagi F, Yamaoka N, Kaneko K; Nucleosides Nucleotides Nucleic Acids., 41(12):1287-1295 (2022)
17.
Xanthinuria Type 1 with a Novel Mutation in Xanthine Dehydrogenase and a Normal Endothelial Function; Miyazaki S, Hamada T, Sugihara S, Mizuta E, Endo Y, Ohtahara A, Komatsu K, Kuwabara M, Fukuuchi T, Kaneko K, Ichida K, Ogino K, Ninomiya H, Yamamoto K, Nakamura T, Hisatome I; Intern Med., 61(9):1383-1386 (2022)
18.
Lysophosphatidic acid receptor1/3 antagonist inhibits the activation of satellite glial cells and reduces acute nociceptive responses; Hoshino Y, Okuno T, Saigusa D, Kano K, Yamamoto S, Shindou H, Aoki J, Uchida K, Yokomizo T, Ito N; FASEB J., 36(4):e22236 (2022)
19.
Urine autotaxin levels reflect the disease activity of sarcoidosis; Murakami K, Tamada T, Saigusa D, Miyauchi E, Nara M, Ichinose M, Kurano M, Yatomi Y, Sugiura H; Sci Rep., 14;12(1):4372 (2022)
20.
Increased Lung Uric Acid Deteriorates Pulmonary Arterial Hypertension; Watanabe T, Ishikawa M, Abe K, Ishikawa T, Imakiire S, Masaki K, Hosokawa K, Fukuuchi T, Kaneko K, Ohtsubo T, Hirano M, Hirano K, Tsutsui H; J Am Heart Assoc., 7;10(23):e022712 (2021)
21.
Effects of islatravir (4'-ethynyl-2-fluoro-2'-deoxyadenosine or EFdA) on renal tubular cells and islatravir's interactions with organic anion transporters; Kaneko M, Reien Y, Morio H, Fukuuchi T, Kaneko K, Hirayama Y, Hashimoto H, Kuwata N, Mitsuya H, Anzai N; J Pharmacol Sci., 146(2):82-87 (2021)
22.
Measurement of the total purine contents and free nucleosides, nucleotides, and purine bases composition in Japanese anchovies (Engraulis japonicus) using high-performance liquid chromatography with UV detection; Takayanagi F, Fukuuchi T, Yamaoka N, Kaneko K; Nucleosides Nucleotides Nucleic Acids.,39(10-12):1458-1464.(2020)
23.
Differentiation of Positional Isomers of Halogenated Benzoylindole Synthetic Cannabinoid Derivatives in Serum by Hybrid Quadrupole/Orbitrap Mass Spectrometry. Fukuuchi T, Moriya SS, Sugiyama T, Tabata H, Kaneko K.Anal Sci. 10;37(2):329-335, 2021
24.
西京味噌浸漬によるめかじきのプリン体組成の変化。高柳 ふくえ, 福内 友子, 山岡 法子, 安田 誠, 馬渡 健一, 奥 直人, 金子 希代子。痛風と尿酸・核酸 (2435-0095)44巻2号 Page177-185(2020)
25.
Measurement of the total purine contents and free nucleosides, nucleotides, and purine bases composition in Japanese anchovies (Engraulis japonicus) using high-performance liquid chromatography with UV detection.Takayanagi F, Fukuuchi T, Yamaoka N, Kaneko K. Nucleosides Nucleotides Nucleic Acids. 39(10-12):1458-1464, 2020
26.
Determination of Total Purine and Purine Base Content of 80 Food products to Aid Nutritional Therapy for Gout and Hyperuricemia.. K. Kaneko, F. Takayanagi, T. Fukuuchi, N. Yamaoka, S. Fujimori, Nucleosides Nucleotides Nucleic Acids. 39(10-12):1449-1457, 2020
27.
Species-dependent patterns of incorporation of purine mononucleotides and nucleosides by lactic acid bacteria. Kano H, Saito C, Yamada N, Fukuuchi T, Yamaoka N, Kaneko K, Asami Y. Nucleosides Nucleotides Nucleic Acids. 39(10-12):1440-1448, 2020
28.
Lactobacillus gasseri PA-3 directly incorporates purine mononucleotides and utilizes them for growth.Yamada N, Saito C, Kano H, Fukuuchi T, Yamaoka N, Kaneko K, Asami Y.Nucleic Acids. 20:1-10, 2020
29.
Lactic Acid Bacteria Show Different Patterns of Incorporation of Purine Mononucleotides and Nucleosides Depending on the Species. H. Kano, C. Saito, N. Yamada, T. Fukuuchi, N. Yamaoka and K. Kaneko. Nucleosides Nucleotides Nucleic Acids. 39(10-12):1440-1448, 2020
30.
Lactobacillus Gasseri PA-3 Incorporates Purine Mononucleotides and Utilizes Them for RNA/DNA Synthesis. N. Yamada, C. Saito, H. Kano, Y. Fukuuchi, N. Yamaoka, K. Kaneko, and Y. Asami. Nucleosides Nucleotides Nucleic Acids. 20;1-10. 2020
31.
Determination of Total Purine and Purine Base Content of 80 Food products to Aid Nutritional Therapy for Gout and Hyperuricemia.. K. Kaneko, F. Takayanagi, T. Fukuuchi, N. Yamaoka, S. Fujimori, Nucleosides Nucleotides Nucleic Acids. 2020 Apr 20:1-9. doi: 10.1080/15257770.2020.1748197.
32.
Determination of Dipicolinic Acid in "Natto" by High Performance Liquid Chromatography Coupled with Postcolumn Photoirradiation with Zinc Acetate. Mawatari KI, Atsumi M, Nakamura F, Yasuda M, Fukuuchi T, Yamaoka N, Kaneko K, Nakagomi K, Oku N. Int J Tryptophan Res. 2019 Jun 19;12:1178646919852120. doi: 10.1177/1178646919852120. eCollection 2019.
33.
Simultaneous Determination of Kynurenine and Kynurenic Acid by High-Performance Liquid Chromatography Photoirradiation System Using a Mobile Phase Containing 18-crown-6. Atsumi M, Mawatari KI, Morooka A, Yasuda M, Fukuuchi T, Yamaoka N, Kaneko K, Nakagomi K, Oku N. Int J Tryptophan Res. 2019 Mar 14;12:1178646919834551. doi: 10.1177/1178646919834551. eCollection 2019.
34.
Sensitive Analysis of Sialic Acid and Related Compound by Hydrophilic Interaction Liquid Chromatography Using Fluorescence Detection after Derivatization with DBD-PZ. A.Kawasaki, M.Yasuda, K.Mawatari, T.Fukuuchi, N.Yamaoka, K.Kaneko, R.Iijima, S.Yui, M.Satoh and K.Nakagomi. Anal. Sci. 34: 841-844, 2018
35.
Change in the Purine Composition of Food by Soaking in Sake Lees. Takayanagi F, Fukuuchi T, Yamaoka N, Kaneko K. Nucleosides, Nucleotides and Nucleic Acids 37 (5): 273-279, 2018
36.
Measurement of Purine Content in Umami Soup And Evaluation of its Effects on Extra- And Intracellular Purine Metabolism Using HPLC Simultaneous Determination. Fukuuchi T, Iyama N, Yamaoka N, Kaneko K. Nucleosides, Nucleotides and Nucleic Acids 37(6): 348-352, 2018
37.
Proteomic Analysis of A Urinary Stone with Two Layers Composed of Calcium Oxalate Monohydrate and Uric Acid. Kaneko K, Kabeya M, Kondo H, Fukuuchi T, Yamaoka N, Yasuda M, .Yamagichi S. Nucleosides, Nucleotides and Nucleic Acids: https://doi.org/10.1080/15257770.2018.1478095.
38.
湯煎および電子レンジ加熱調理による食品中のプリン体含量の変動。福内 友子, 岩崎 円香, 山岡 法子, 金子 希代子。痛風と核酸代謝(1344-9796)42巻2号 Page165-172(2018.12)
39.
Clinical studies on changes in purine compounds in blood and urine by the simultaneous administration of febuxostat and inosine, or by single administration of each. Kamatani N, Hashimoto M, Sakurai K, Gokita K, Yoshihara J, Sekine M, Mochii M, Fukuuchi T, Yamaoka N, and Kaneko K. Gout and Nucleic Acid Metabolism 141 (2): 171-181, 2017
40.

.
Evaluation of cellular purine transport and metabolism in the Caco-2 cell using comprehensive high-performance liquid chromatography method for analysis of purines. Fukuuchi, T.,Kobayashi, M.,Yamaoka, N.,Kaneko, K.. Nucleosides, Nucleotides and Nucleic Acids 35(10-12), pp. 663-669 2016
41.
Analysis of l-DOPA-derived melanin and a novel degradation product formed under alkaline conditions. Hidetoshi Omotani, Makoto Yasuda, Ritsuko Ishii, Tsukasa Ikarashi, Tomoko Fukuuchi, Noriko Yamaoka, Ken-ichi Mawatari, Kiyoko Kaneko, Kazuya Nakagomi. Journal of Pharmaceutical and Biomedical Analysis. 125: 22-26, 2016.
42.
Urinary excretion of uric acid, allantoin, and 8-OH-deoxyguanosine in uricase-knockout mice. K. Inazawa, S. Yamaguchi, M. Hosoyamada, T. Fukuuchi, N. H. Tomioka, N. Yamaoka, and K. Kaneko. Nucleosides, Nucleotides and Nucleic Acids. 35(10-12): 559-565, 2016
43.
Evaluation of purine utilization by Lactobacillus gasseri strains with potential to decrease the absorption of food-derived purines in the human intestine. N. Yamada, C. Iwamoto, H. Kano, N. Yamaoka, T. Fukuuchi, K. Kaneko, and Y. Asami. Nucleosides, Nucleotides and Nucleic Acids. 35(10-12): 670-676, 2016
44.
Proteomic Analysis after Sequential Extraction of Matrix Proteins in Urinary Stones Composed of Calcium Oxalate Monohydrate and Calcium Oxalate Dihydrate. Kiyoko Kaneko, Shin-ichiro Nishii, Yoko Izumi, Makoto Yasuda, Tomoyo Yamanobe, Tomoko Fukuuchi, Noriko Yamaoka, and Shigeo Horie. Ana Sci 31(9): 935-942, 2015
45.
Analysis of Intra- and Extracellular Levels of Purine Bases, Nucleosides, and Nucleotides in HepG2 cells by High-performance Liquid Chromatography. Tomoko Fukuuchi, Noriko Yamaoka, and Kiyoko Kaneko. Ana Sci 31(9): 895-901, 2015
46.
Total Purine and Purine Base Content of Common Foodstuffs for Facilitating Nutritional Therapy for Gout and Hyperiricemia. Kaneko K, Aoyagi Y, Inazawa K, Fukuuchi T, Yamaoka N.Biological and Pharmaceutical Bulletin 37 (5), 709-72, 2014
47.
食品中プリン体含量および塩基別含有率の比較。金子希代子、福内友子、稲沢克紀、山岡法子、藤森 新。痛風と核酸代謝 39(1): 7-21, 2015
48.
Characterizing substrate properties of purine-related compounds with purine metabolism enzymes for enzymatic peak-shift HPLC method. Fukuuchi T, Morimura A, Kawatani M, Yamamoto K, Yamaoka N, Kaneko K. Nucleosides Nucleotides Nucleic Acids., 33(4-6), 445-453. 2014
49.
Proteomic analysis of a rare urinary stone composed of calcium carbonate and calcium oxalate dihydrate: A case report. Kaneko K, Matsuta Y, Moriyama M, YasudaM, ChishimaN, Yamaoka N, Fukuuchi T, Miyazawa K, and Suzuki K. Int J Urol, 21: 341-346, 2014. (doi: 10.1111/iju.12282, 2013)
50.
Determination and profiling of purines in foods by using HPLC and LC-MS. Inazawa K, Sato A, Kato Y, Yamaoka N, Fukuuchi T, Yasuda M, Mawatari K, Nakagomi K, and Kaneko K. Nucleosides Nucleotides Nucleic Acids., 33(4-6), 439-444.2014
51.
Development of a fluorescence analysis method for N-acetylneuraminic acid and its oxidized product ADOA. Ota T, Yasuda M, Iijima R, Yui S, Mawatari K, Fukuuchi T, Yamaoka N, Kaneko K, Nakagomi K. Journal of Chromatography B, 932: 152-157, 2013
52.
Simultaneous determination of nicotine and cotinine in serum using high-performance liquid chromatography with fluorometric detection and postcolumn UV-photoirradiation system. Yasuda M, Ota T, Morikawa A, Mawatari K, Fukuuchi T, Yamaoka N, Kaneko K, Nakagomi K Journal of Chromatography B, 934: 41-45, 2013..
53.
Proteomic analysis to examine the role of matrix proteins in a gouty tophus from a patient with recurrent gout. Kaneko K, Iwamoto H, Yasuda M, Inazawa K, Yamaoka N, Fukuuchi T, Tamura Y, Uchida S, Mawatari K, Nakagomi K, Yamada Y, and Fujimori S. Nucleosides Nucleotides Nucleic Acids., 33(4-6), 199-207. 2014
54.
A simple HPLC method for determining the purine content of beer and beer-like alcoholic beverages. Fukuuchi T, Yasuda M, Inazawa K, Ota T,Yamaoka N, Mawatari K, Nakagomi K, and Kaneko K. Analytical Sciences, 29: 511-517, 2013
55.
Enhancing Effect of Aged Garlic Extract on Induction of Morphological Differentiation with Neurite Outgrowth in NGF-treated PC12 Cells. Kohda K., Itoh K., Goda H., Samejima K., Fukuuchi T., Morihara N., Imamura K., Kodera Y., Oka T.; Pharmacology & Pharmacy, 3: 37-43, 2012
56.
Simultaneous determination of purine and pyrimidine metabolites in HPRT-deficient cell lines. Yamaoka N, Inazawa K, Inagawa S, Fujimori S., Yasuda M., Mawatari K., Nakagomi K., Yamada Y., and Kaneko K.; Nucleosides Nucleotides Nucleic Acids, 30 (12): 1256-1259, 2011
57.
HPLC及びLC-MSを用いたきのこ4種中のプリン体プロファイリング。稲沢克紀、山岡法子、稲川覚子、安田誠、馬渡健一、中込和哉、久留一郎、金子希代子; 痛風と核酸代謝, 35 (2): 175-181, 2011
58.
Detection of mutant uromodulin in transgenic mouse harboring a mutant human UMOD gene. Yasuda M, Kaneko K, Hachisu H, Yamaoka N, Mawatari K, Nakagomi K, Minoura N, Hosoyamada M; Nucleosides Nucleotides Nucleic Acids, 30 (12): 1284-1289, 2011
59.
Molecular analysis of X-Linked inborn errors of purine metabolism: HPRT1 and PRPS1 mutations. Yamada.Y., YamadaK., Nomura N., Yamano A, Kimura R., Naiki M., Fukushi., Wakamatsu N., Taniguchi A., Yamaoka N., Kaneko K., Fujimori S.; Nucleosides Nucleotides Nucleic Acids, 30 (12): 1272-1275, 2011
60.
Novel pathway of metabolic activation of bisphenol A-related compounds for estrogenic activity.Okuda K., Fukuuchi T., Takiguchi M., Yoshihara S.; Drug metabolism and disposition, 39(9): 1696-1703,2011
61.
Simultaneous determination of nucleosides and nucleotides in dietary foods and beverages using ion-pairing liquid chromatography-electrospray ionization-mass spectrometry. Yamaoka N., Kudo Y., Inazawa K., Inagawa S., Yasuda M., Mawatari K., Nakagomi K., and Kaneko K.; J Chromatography B 878: 2054-2060, 2010
著書リスト・その他
1.
アルコールと核酸代謝異常。【アルコールによる代謝異常と疾患】、金子 希代子, 福内 友子, 高柳 ふくえ, 山岡 法子。糖尿病・内分泌代謝科(2435-1946)52巻1号 Page14-21(2021.01)
2.
『血清尿酸値を上昇させる食生活』 in 特集/心血管疾患の残余リスクとしてのキサンチンオキシダーゼ(XO)。金子希代子、福内友子、高蛯モくえ、山岡法子:循環器内科 87 (1): 95-101, 2020.
3.
『食品中のプリン体と過剰摂取による痛風・高尿酸血症のリスク』 in 特集 高尿酸血症と痛風における生活指導の最前線?「高尿酸血症・痛風の治療ガイドライン第3版」より。金子希代子、福内友子、高蛯モくえ、山岡法子:臨床栄養 135 (2): 177-183, 2019.
4.
アルコール飲料中のプリン体と血清尿酸値への影響 【高尿酸血症と痛風における生活指導の最前線-「高尿酸血症・痛風の治療ガイドライン第3版」より】 山岡 法子, 福内 友子。臨床栄養(0485-1412)135巻2号 Page190-193(2019.08)
5.
プリン体の測定と食事療法への応用。金子希代子、福内友子、高蛯モくえ、山岡法子:痛風と尿酸・核酸 43 (1): 1-9, 2019.7
6.
第20章 核酸代謝学?機器分析を用いたプリン代謝研究?。 in『代謝センシング』。三林浩二監修。金子希代子、福内友子、山岡法子:pp172-184、シーエムシー出版、2018年9月
7.
『分析化学 II 第2版』 福内友子: 中込和哉、秋澤俊史編、朝倉書店
8.
『薬学生のための漢方医薬学 第3版』 p310-312、山岡法子、小林義典、南江堂、2017、3月
9.
酒類中のプリン体含量と尿酸値との関連。【高尿酸血症・低尿酸血症-最近の診断と治療-】 高尿酸血症の臨床 高尿酸血症・痛風の検査・診断・治療、 金子 希代子、福内 友子, 山岡 法子。日本臨床、74巻増刊9 高尿酸血症・低尿酸血症: 288-293、2016.
10.
非薬物性(高プリン体食品、アルコール、果糖)の要因による高尿酸血症。【高尿酸血症・低尿酸血症-最近の診断と治療-】 高尿酸血症の臨床 高尿酸血症の病理・病態 二次性高尿酸血症(産生過剰型・排泄低下型・混合型) 金子 希代子、山岡 法子, 福内 友子。日本臨床、74巻増刊9、 高尿酸血症・低尿酸血症:161-165、2016. 
11.
リポート:薬学部漢方教育のいま・これから?、山岡法子、漢方医薬学雑誌:vol.23, No.3, p100-101, 2015、12月
12.
『生薬処方電子事典U」(CD-ROM) 木下武司、山岡法子著、OFFICE21、2012, 8