 帝京大学薬学部 |
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| 薬物動態学研究室 | ||
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論文リスト | |
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1.
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Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening; Moeno Kadoguchi, Hiroshi Arakawa, Ryokichi Honda, Kazuki Hotta, Yoshiyuki Shirasaka, Yoshiharu Deguchi, Ikumi Tamai; Pharm. Res., 39(7), 1549-1559 (2022) | |
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Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics; Irena Loryan, David E Smith, Per Artursson, Douwe Breimer, Yoshiharu Deguchi, Lennart Paalzow, Yuichi Sugiyama, Tetsuya Terasaki, Elizabeth C M de Lange; Pharm. Res., 39(7), 1283-1289 (2022) | |
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3.
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Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood-Brain Barrier; Toshiki Kurosawa, Yuma Tega, Yasuo Uchida, Kei Higuchi, Hidetsugu Tabata, Takaaki Sumiyoshi, Yoshiyuki Kubo, Tetsuya Terasaki, Yoshiharu Deguchi; Pharmaceutics, 14(8), 1683 (2022) | |
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4.
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Functional characteristics of 3'-azido-3'-deoxythymidine transport at the blood-testis barrier; Takeru Ito, Yoshiyuki Kubo, Shin-Ichi Akanuma, Ken-Ichi Hosoya; Int. J. Pharm., 625:122044 (2022) | |
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5.
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Naltrexone Transport by a Proton-Coupled Organic Cation Antiporter in hCMEC/D3 Cells, an in Vitro Human Blood-Brain Barrier Model; Atsushi Kitamura, Kei Higuchi, Toshiki Kurosawa, Takashi Okura, Yoshiyuki Kubo, Yoshiharu Deguchi; Biol. Pharm. Bull., 45(10), 1585-1589 (2022) | |
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6.
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Construction and Functional Evaluation of a Three-Dimensional Blood–Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells.; Toshiki Kurosawa, Daiki Sako, Yuma Tega, Yasuyuki Debori, Yumi Tomihara, Kazunobu Aoyama, Yoshiyuki Kubo, Nobuyuki Amano, Yoshiharu Deguchi.; Pharm Res. Online ahead of print. (2022) | |
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7.
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Involvement of TauT/SLC6A6 in Taurine Transport at the Blood-Testis Barrier.; Yoshiyuki Kubo, Sakiko Ishizuka, Takeru Ito, Daisuke Yoneyama, Shin-Ichi Akanuma, Ken-Ichi Hosoya.; Metabolites. 12(1):66. (2022) | |
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8.
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Transport Characteristics of 6-Mercaptopurine in Brain Microvascular Endothelial Cells Derived From Human Induced Pluripotent Stem Cells.; Toshiki Kurosawa, Yuma Tega, Daiki Sako, Tatsuki Mochizuki, Tomoko Yamaguchi, Kenji Kawabata, Katsuhisa Inoue, Naoki Ito, Hiroyuki Kusuhara, Yoshiharu Deguchi.; J Pharm Sci. 110(10):3484-3490. (2021) | |
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9.
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Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier.; Tatsuki Mochizuki, Tadahaya Mizuno, Toshiki Kurosawa, Tomoko Yamaguchi, Kei Higuchi, Yuma Tega, Yoshitane Nozaki, Kenji Kawabata, Yoshiharu Deguchi and Hiroyuki Kusuhara.; Drug Metab Dispos. 49(1):3-11 (2021) | |
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10.
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Fibronectin is essential for formation of fenestrae in endothelial cells of the fenestrated capillary.; Takashi Nakakura, Takeshi Suzuki, Hideyuki Tanaka, Kenjiro Arisawa, Toshio Miyashita, Yoko Nekooki-Machida, Toshiki Kurosawa, Yuma Tega, Yoshiharu Deguchi, Haruo Hagiwara.; Cell Tissue Res. 383(2):823-833 (2021) | |
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11.
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Structural Requirements for Uptake of Diphenhydramine Analogs into hCMEC/D3 Cells Via the Proton-Coupled Organic Cation Antiporter.; Yuma Tega, Hidetsugu Tabata, Toshiki Kurosawa, Atsushi Kitamura, Fumio Itagaki, Tetsuta Oshitari, Yoshiharu Deguchi.; J Pharm Sci. 110(1):397-403 (2021) | |
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12.
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血液脳関門透過性を有するヒストン脱アセチル化酵素阻害剤の探索; 住吉孝明, 平中誠弥, 出口芳春, 伊藤昭博, 吉田稔; MEDCHEM NEWS Vol. 30 No. 1 (2020) | |
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13.
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Expression and functional characterization of SLC transporters in brain microvascular endothelial cells derived from human induced pluripotent stem cells, Yuma Tega, Toshiki Kurosawa, Kei Higuchi, Tomoko Yamaguchi, Takashi Nakakura, Tatsuki Mochizuki, Hiroyuki Kusuhara, Kenji Kawabata, Yoshiharu Deguchi, Abstracts from the 13th International Conference on Cerebral Vascular Biology (CVB 2019), Fluids and Barriers of the CNS, 16 (2019) | |
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14.
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Expression and Functional Characterization of Drug Transporters in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.; Kurosawa T, Tega Y, Higuchi K, Yamaguchi T, Nakakura T, Mochizuki T, Kusuhara H, Kawabata K, and Deguchi Y.; Mol. Pharmaceut., 15(12), 5546-5555 (2018) | |
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15.
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Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line;Takahashi Y, Nishimura T, Higuchi K, Noguchi S, Tega Y, Kurosawa T, Deguchi Y, and Tomi M.; Pharm Res. 35(12), 246 (2018) | |
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16.
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Impact of Nicotine Transport across the Blood-Brain Barrier: Carrier-Mediated Transport of Nicotine and Interaction with Central Nervous System Drugs; Tega Y, Yamazaki Y, Akanuma SI, Kubo Y, and Hosoya KI.; Biol Pharm Bull., 41(9),1330-1336 (2018) | |
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17.
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Design, synthesis, and blood-brain barrier transport study of pyrilamine derivatives as histone deacetylase inhibitors; Hiranaka S, Tega Y, Higuchi K, Kurosawa T, Deguchi, Y, Arata M, Ito A, Yoshida M, Nagaoka Y, and Sumiyoshi T.;ACS Med. Chem. Lett., 9(9), 884-888 (2018) | |
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18.
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Recent advances in research on biological membranes that regulate the central nervous system; Nakanishi T, Tamai I, and eguchi Y.; Biol. Pharm. Bull. 41(9), 1322-1323 (2018) | |
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Prostaglandin Transporter OATP2A1/SLCO2A1 Is Essential for Body Temperature Regulation during Fever; Nakamura Y, Nakanishi T, Shimada H, Shimizu J, Aotani R, Maruyama S, Higuchi K, Okura T, Deguchi Y, and Tamai I.; J. Neurosci. 38(24), 5584-5595 (2018) | |
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20.
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Involvement of proton-coupled organic cation antiporter in varenicline transport at blood-brain barrier of rats and in human brain capillary endothelial cells; Kurosawa T, Higuchi K, Okura T, Kobayashi K, Kusuhara H, and Deguchi Y.; J. Pharm. Sci., 106(9), 2576-2582 (2017) | |
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21.
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Functional expression of nicotine influx transporter in A549 human alveolar epithelial cells. Tega Y, Yuzurihara C, Kubo Y, Akanuma SI, Ehrhardt C, Hosoya KI. Drug Metab. Pharmacokinet., 31(1), 99-101(2016) |
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22.
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Histamine elimination from the cerebrospinal fluid across the blood-cerebrospinal fluid barrier . Involvement of plasma membrane monoamine transporter (PMAT/SLC29A4). Usui T, Nakazawa A, Okura T, Deguchi, Y, Akanuma SI, Kubo Y, Hosoya K; J Neurochem. 139, 408 ? 418 (2016) | |
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23.
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Cocktail-dosing microdialysis study to simultaneously assess delivery of multiple organic-cationic drugs to the brain. Kitamura A, Higuchi K, Okura T, Deguchi Y; J. Pharm. Sci. 105, 935-940 (2016) | |
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24.
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Involvement of the H+/organic cation antiporter in nicotine transport in rat liver. Tega Y, Akanuma S, Kubo Y, Hosoya K. Drug Metab. Dispos., 43(1), 89-92 (2015) | |
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25.
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Carrier-Mediated Transport of Nicotine Across the Inner Blood-Retinal Barrier: Involvement of a Novel Organic Cation Transporter Driven by an Outward H(+) Gradient. Tega Y, Kubo Y, Yuzurihara C, Akanuma S, Hosoya K. J. Pharm. Sci., 104(9), 3069-3075 (2015) | |
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26.
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The blood-brain barrier transport mechanism controlling analgesic effects of opioid drugs in CNS. Okura T, Higuchi K, Deguchi Y; Yakugaku Zasshi. 135, 697-702 (2015). | |
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27.
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Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model; Higuchi K, Kitamura A, Okura T, Deguchi Y; Drug Metab Pharmacokinet., 30 (2), 182-187 (2015) | |
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28.
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Endothelin-1 receptors in rat tissues: characterization by bosentan, ambrisentan and CI-1020; Yoshinari Yokoyama, Ayaka Osano, Hideki Hayashi, Kunihiko Itoh, Takashi Okura, Yoshiharu Deguchi, Yoshihiko Ito, Shizuo Yamada; Biol. Pharm. Bull., 37 (3), 461-465 (2014) | |
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29.
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Fetal Growth Retardation and Lack of Hypotaurine in Ezrin Knockout Mice; Nishimura T, Higuchi K, Sai Y, Sugita Y, Yoshida Y, Tomi M, Wada M, Wakayama T, Tamura A, Tsukita S, Soga T, Nakashima E; PLoS One. 9 (8), e105423 (2014) | |
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30.
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Transport characteristics of tramadol in the blood-brain barrier; Atsushi Kitamura, Kei Higuchi, Takashi Okura, and Yoshiharu Deguchi; J. Pharm. Sci., 103 (10), 3335-3341 (2014) | |
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31.
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Functional expression of organic cation/carnitine transporter 2 (OCTN2/SLC22A5) in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model; Okura T, Kato S, Deguchi Y; Drug Metab Pharmacokinet., 29 (1), 69-74 (2014) | |
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32.
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System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts; Nishimura T, Yagi R, Usuda M, Oda K, Yamazaki M, Suda S, Takahashi Y, Okazaki F, Sai Y, Higuchi K, Maruyama T, Tomi M, Nakashima E; Biochim Biophys Acta., 1838( 5),1306-1312 (2014) | |
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33.
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Proton-Coupled Organic Cation Antiporter-Mediated Uptake of Apomorphine Enantiomers in Human Brain Capillary Endothelial Cell Line hCMEC/D3; Okura T, Higuchi K, Kitamura A, Deguchi Y; Biol Pharm Bull., 37 (2), 286?291 (2014) | |
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34.
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Bladder endothelin-1 receptor binding of bosentan and ambrisentan; Osano A, Yokoyama Y, Hayashi H, Itoh K, Okura T, Deguchi Y, Ito Y, Yamada S; J Pharmacol Sci., 124(1), 86-91 (2014) | |
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35.
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Muscarinic receptor binding of the novel radioligand, [(3)h]imidafenacin in the human bladder and parotid gland; Yoshida A, Kuraoka S, Ito Y, Okura T, Deguchi Y, Otsuka A, Ozono S, Takeda M, Masuyama K, Araki I, Yamada S; J. Pharmcol. Sci., 124 (1), 40-46 (2014) | |
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36.
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Ependymal cells of the mouse brain express urate transporter 1 (URAT1); Tomioka NH, Nakamura M, Doshi M, Deguchi Y, Ichida K, Morisaki T, Hosoyamada M; Fluids Barriers CNS., 10 (1), 31. doi: 10.1186/2045-8118-10-31. (2013) | |
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37.
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Evaluation of rat in vivo fetal-to-maternal transfer clearances of various xenobiotics by umbilical perfusion; Nishimura T, Takanohashi T, Tomi M, Horikoshi M, Higuchi K, Sai Y, Nakashima E; J Pharm Sci.,102 (9), 3356-3363 (2013) | |
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38.
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Estrogen receptor α induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells; Oda K, Nishimura T, Higuchi K, Ishido N, Ochi K, Iizasa H, Sai Y, Tomi M, Nakashima E; J Pharm Sci.,102(9), 3364-3372 (2013) | |
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39.
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Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model; Keita Shimomura, Takashi Okura, Sayaka Kato, Pierre-Oliver Couraud, Yoshiharu Deguchi; Fluid Barrier CNS, 10:8, (2013). | |
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40.
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Characterization of the Carrier-mediated Transport of Ketoprofen, a Nonsteroidal Anti-Inflammatory Drug, in Rabbit Corneal Epithelium Cells; Shinobu Fujii, Hideki Hayashi, Kunihiko Itoh, Shizuo Yamada, Yoshiharu Deguchi and Kouichi Kawazu; J. Pharm. Pharmacol., 65, 171-180 (2013) | |
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41.
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Blood-to-brain influx transport of nicotine at the rat blood-brain barrier: involvement of a pyrilamine-sensitive organic cation transport process. Tega Y, Akanuma S, Kubo Y, Terasaki T, Hosoya K. Neurochem. Int., 62(2), 173-81 (2012) |
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42.
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Measurement of glomerular filtration rate by rapid intravenous injection of a newly developed insulin fraction; Yoshitaka Maeda, Yuya Araki, Tomomi Uno, Akiho Yoshida Keisuke Nishigaki, Naoto Inaba, Hiroaki Hayashi, and Yoshiharu Deguchi; J. Rural Med, 6(1), 9-15 (2011) | |
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43.
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The blood-brain barrier as a focus of drug metabolism and pharmacokinetics; Yoshiharu Deguchi; Drug Metab. Pharmacokinet. 26 (3), 1 (2011) | |
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44.
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Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo; Muhammad Waqas Sadiq, Annika Borgs, Takashi Okura, Keita Shimomura, Sayaka Kato, Yoshiharu Deguchi, Britt Jansson1, Sven Bjorkman, Tetsuya Terasaki, Margareta Hammarlund-Udenaes; J. Pharm. Sci., 100 (9), 3912 - 3923 (2011) | |
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45.
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Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers; Takashi Okura, Sayaka Kato, Yusuke Takano, Takenori Sato, Atsushi Yamashita, Riyo Morimoto, Sumio Ohtsuki, Tetsuya Terasaki, Yoshiharu Deguchi; J. Pharm. Sci. 100 (9), 3924 - 3938 (2011) | |
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46.
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Differential expression of ezrin and CLP36 in the two layers of syncytiotrophoblast in rats; Higuchi K., Iizasa H, Sai Y, Horieya S, Lee K. E, Wada M, Deguchi M, Nishimura T, Wakayama T, Tamura A, Tsukita S, Kose N, Kang Y. S, and Nakashima E; Biol. Pharm. Bull., 33(8), 1400-1406 (2011) | |
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47.
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Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier transport and antinociceptive effect; Yusuke Nakazawa, Takashi Okura, Keita Shimomura, Tetsuya Terasaki, Yoshiharu Deguchi; J. Pharm. Sci., 99, 467-474 (2010). | |
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48.
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Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells; Takashi Okura, Michiko Ibe, Keizo Umegaki, Kazumasa Shinozuka, Shizuo Yamada; Biol. Pharm. Bull. 33, 255-259 (2010) | |
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49.
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A possible mechanism for the decrease in serum thyroxine level by a TCDD-like PCB congener, 3,3',4,4',5- pentachlorobiphenyl in mice; Yoshihisa Kato, Koichi Haraguchi, Makio Kubota, Yoshiki Seto, Takashi Okura, Shin-ichi Ikushiro, Nobuyuki Koga, Shizuo Yamada, Masakuni Degawa; Drug Metab. Dispos. 38, 150-156 (2010) | |
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50.
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Genetic deficiency of carnitine/organic cation transporter2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice; Sayaka Kato, Yukio Kato, Tadakatsu Nakamura, Tomoko Sugiura, Yoshiyuki Kubo, Yoshiharu Deguchi, and Akira Tsuji; Bio. Drug Dispos., 39, 495-507 (2009). | |
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51.
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Effects of repeated morphine treatment on the antinociceptive effects, intestinal absorption, and efflux from intestinal epithelial cells of morphine; Takashi Okura, Tadahiro Ozawa, Michiko Ibe, Yuko Taki, Midori Kimura, Yoshiyuki Kagawa, Yoshihisa Kato, Shizuo Yamada; Biol. Pharm. Bull. 32, 1571-1575 (2009) | |
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52.
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Effects of quinidine on antinociception and pharmacokinetics of morphine in rats; Takashi Okura, Yuki Morita, Yoshihiko Ito, Yoshiyuki Kagawa, Shizuo Yamada; J. Pharm. Pharmacol. 61, 593-597 (2009) | |
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53.
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Involvement of Pyrilamine Transporter, a Putative Organic Cation Transporter, in Blood-Brain Barrier Transport of Oxycodone: Takashi. Okura, Asami. Hattori, Yusuke Takano, Takenori Sato, Margareta Hummerlund-Udenaes, Tetsuya Terasaki and Yoshiharu Deguchi; Drug Metab. Dispos., 36(10), 2005 - 2013 (2008). | |
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54.
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Enhancement by grapefruit juice of morphine antinociception; Takashi Okura, Tadahiro Ozawa, Yoshihiko Ito, Midori Kimura, Yoshiyuki Kagawa, Shizuo Yamada; Biol. Pharm. Bull. 31, 2338-2341 (2008) | |
55. |
Comparative Analysis of Partition Coefficients in Linear and Nonlinear eliminating organs without measurering tissue concentrations; H. Ito, N. Kose, Y. Deguchi, L. Z. Benet, E. Nakashima, J. Kyoritsu Univ. Pharm., 3, 9-18 (2007). | |
56. |
Blood-brain barrier transport of pramipexole, a dopamine D2 agonist; Takashi Okura, Rie Ito, Naoki Ishiguro, Ikumi Tamai and Yoshiharu Deguchi; Life Sci., 80: 1564 - 1571 (2007) | |
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57.
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Comparative measurement of spinal CSF microdialysate concentrations and concomitant antinociception of morphine and morphine-6b-glucuronide in rats; T Okura, N Komiyama, Y Morita, M Kimura, Y Deguchi and S Yamada; Life Sci., 80: 1319 - 1326 (2007). | |
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58.
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Prediction of α1-adrenoceptor occupancy in the human prostate from plasma concentrations of silodosin, tamsulosin and terazosin to treat urinary obstruction in benign prostatic hyperplasia; Shizuo Yamada, Yasuhiro Kato, Takashi Ohkura, Yoshiyuki Kagawa and Kazuki Kawabe; Biol. Pharm. Bull. 30, 1237-1241 (2007) | |
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59.
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Different effects of morphine and morphine-6β-glucuronide on formalin-evoked spinal glutamate release in conscious and freely-moving rats; Takashi Okura, Noriyuki Komiyama, Yuki Morita, Midori Kimura, Shizuo Yamada; Neurosci. Lett. 415, 169-173 (2007) | |
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著書リスト・その他 | |
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1.
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分担執筆 久保義行、出口芳春； エピソード 薬物動態学 第2版 TSUJI's PHARMACOKINETICS -薬物動態学の解明-； 京都廣川書店 (2023) | |
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2.
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ヒトiPS細胞由来血液脳関門モデルの構築とトランスポーター機能評価; 黒澤俊樹、佐孝大樹、久保義行、出口芳春; Drug Delivery System, Vol.38 No.2 (2023) | |
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3.
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分担執筆 出口芳春; わかりやすい薬物動態計算問題の解き方; ネオメディカル (2019) | |
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4.
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薬物速度論 (1), (2); 出口芳春; 薬の生体内運命 (改定第8版); ネオメディカル; pp. 144 - 165 (2019) | |
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5.
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添付文書がちゃんと読める物理・化学; 高橋秀依, 出口芳春, 夏苅英昭(監修); じほう (2017) | |
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6.
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薬物速度論(1); 出口芳春; 薬の生体内運命（改訂第７版）; ネオメディカル; pp. 136 - 153 (2017) | |
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7.
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妊娠時における薬物のタンパク結合・胎児移行と血液胎盤関門; 3. 出口芳春; パートナー薬剤学（改訂第３版）; 南江堂; pp. 84-88 (2017). | |
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8.
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分布-脳への移行、胎児への移行と胎盤関門; 出口芳春; コンパス生物薬剤学（改訂第２版; 南江堂; pp.82-90 (2016) | |
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9.
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薬物分布実験法 脳関門; 黄倉崇・出口芳春; 薬剤学実験 必携マニュアル; 南江堂; pp.124-137 (2014) | |
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10.
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トロイの木馬抗体を用いた中枢作用型タンパク質・遺伝子医薬開発の最前線; 黄倉崇・出口芳春; 細胞工学; 秀潤社; 962-964; 2013 | |
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11.
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排泄・クリアランス: 出口芳春; 辻' 薬物動態学; 京都廣川書店; 2012 | |
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12.
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分布; 黄倉崇・出口芳春; コンパス生物薬剤学（改訂第２版）; 南江堂; pp. 51 - 67; 2012 | |
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13.
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血液脳関門の輸送機能に魅せられて; 出口芳春; 薬剤学, 71(3), 153 - 158 (2011) | |
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14.
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血液脳関門ペプチド・タンパク輸送系を利用した脳へのデリバリー; - カチオン性ペプチド・タンパクを中心に-; 遺伝子医学MOOK別冊; メディカル・ドゥ, pp. 251-257 (2011) | |
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15.
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分布: 原島秀吉・出口芳春: 新薬剤学（改訂第３版）; 南江堂; pp. 97 - 102 (2011) | |
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16.
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薬動学: 出口芳春: 薬の生体内運命（改訂第４版）; ネオメディカル; pp. 218 - 241 (2009) | |
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