 帝京大学薬学部 |
研究室ページ | English | |
| 物理薬剤学研究室 | ||
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論文リスト | |
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Ceramide synthase CERS4 gene downregulation is associated with KRAS mutation in colorectal cancer; Hayama T., Hama K., Ozawa T., Fujiwara Y., Nozawa K., Matsuda K., Yokoyama K., Hashiguchi Y., Ochiai H., Misawa T., Fukagawa T.; Sci. Rep., 13, 16249.1-8, (2023) | |
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オンデマンド形式の授業による分野横断統合演習の実施と学習効果の検討、岩澤晴代, 岸本成史, 長谷川仁美, 安原眞人, 厚味巌一, 北加代子, 安藤崇仁, 渡邊真知子, 横山和明, 板垣文雄, 長田洋一, 奥直人;薬学教育, 7, doi: 10.24489/jjphe.2023-020, 1-12 (2023) | |
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脂肪酸の選択的重水素化法の開発と脂質・脂肪酸の代謝解析への応用、濱弘太郎, 横山和明, 滝田良;ファルマシア, 59(1), 43-47 (2023)（総説） | |
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Controlled Tetradeuteration of Straight-Chain Fatty Acids: Synthesis, Application, and Insight into the Metabolism of Oxidized Linoleic Acid; Watanabe A., Hama K., Watanabe K., Fujiwara Y., Yokoyama K., Murata S., Takita R.; Angew. Chem. Int. Ed., e202202779.1-11, (2022) | |
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Cathepsin G-induced malignant progression of MCF-7 cells involves suppression of PAF signaling through induced expression of PAFAH1B2; Tanigawa K., Kiriya M., Hayashi Y.,Shinden Y., Kijima Y., Natsugoe S., Sumimoto T., Morimoto-Kamata R., Yui S., Hama K., Yokoyama K., Nakamura Y., Suzuki K., Nojiri H., Inoue K., Karasawa K.; Biochim. Biophys. Acta. Mol. Cell Biol. Lipids, 1867(8) 159164.1-10 (2022) | |
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Application of LC-ESI-MS/MS in the analysis of lipid species in samples from patients with X-linked adrenoleukodystrophy, a peroxisomal disease; Hama K., Fujiwara Y., Yokoyama K., Med. Mass Spectrom., 6, 101-111, (2022) (Review) | |
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Glycosphingolipids with Very Long-Chain Fatty Acids Accumulate in Fibroblasts from Adrenoleukodystrophy Patients Yuko Fujiwara, Kotaro Hama, Nobuyuki Shimozawa, Kazuaki Yokoyama; International Journal of Molecular Sciences, 22(16), 8645.1-8645.19 (2021) | |
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Development of a liquid chromatography-electrospray ionization tandem mass spectrometric method for the simultaneous analysis of free fatty acids. Hyeon-Cheol Lee-Okada, Kotaro Hama, Kazuaki Yokoyama, Takehiko Yokomizo Journal of biochemistry, 170(3), 389-397 (2021) | |
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Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues.Hama K., Fujiwara Y., Hayama T., Ozawa T., Nozawa K., Matsuda K., Hashiguchi Y., and Yokoyama K.Sci. Rep., 11, 6163 (2021) | |
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Hexacosenoyl-CoA is the most abundant very long-chain acyl-CoA in ATP-binding cassette transporter D1-deficient cells.: Hama K, Fujiwara Y, Takashima S, Hayashi Y, Yamashita A, Shimozawa N, Yokoyama K. J. Lipid Res., 61, 523-536 (2020) | |
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Mass spectrometry in combination with a chiral column and multichannel-MRM allows comprehensive analysis of glycosphingolipid molecular species from mouse brain. Fujiwara Y, Hama K, Yokoyama K. Carbohydr. Res. (doi:10.1016/j.carres.2020.107959.) | |
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Quantitative and Qualitative Method for Sphingomyelin by LC-MS Using Two Stable Isotopically Labeled Sphingomyelin Species. Hama K, Fujiwara Y, Yokoyama K. Journal of visualized experiment_May, doi: 10.3791/57293 (2018). | |
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Profiling and Imaging of Phospholipids in Brains of Abcd1-Deficient Mice.Hama K, Fujiwara Y, Morita M, Yamazaki F, Nakashima Y, Takei S, Takashima S, Setou M, Shimozawa N, Imanaka T, Yokoyama K.Lipids. 2018 Jan;53(1):85-102 | |
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Acyl Chain Preference in Foam Cell Formation from Mouse Peritoneal Macrophages.Fujiwara Y, Hama K, Tsukahara M, Izumi-Tsuzuki R, Nagai T, Ohe-Yamada M, Inoue K, Yokoyama K.Biol Pharm Bull. 2018;41(1):86-91. | |
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Comprehensive Quantitation Using Two Stable Isotopically Labeled Species and Direct Detection of N-Acyl Moiety of phingomyelin.Hama K, Fujiwara Y, Tabata H, Takahashi H, Yokoyama K.Lipids. 2017 Sep;52(9):789-799. | |
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Molecular species of phospholipids with very long chain fatty acids in skin fibroblasts of Zellweger syndrome; Hama, K., Nagai, T., Nishizawa, C., Ikeda, K., Morita, M., Satoh, N., Nakanishi, H., Imanaka, T., Shimozawa, N., Taguchi, R., Inoue, K. and Yokoyama, K. Lipids 48(12), 1253-1267 (2013) PMID: 24122089 | |
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Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis; Gotoh, M., Fujiwara, Y., Yue, J., Liu, J., Lee, S., Fells, J., Uchiyama, A., Murakami-Murofushi, K., Kennel, S., Wall, J., Patil, R., Gupte, R., Balazs, L., Miller, D. D., Tigyi, G. J. Biochem. Soc. Trans., 40(1), 31-36 (2012) PMID:22260662 | |
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Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish; Yukiura H., Hama K., Nakanaga K., Tanaka M., Asaoka Y., Okudaira S., Arima N., Inoue A., Hashimoto T., Arai H., Kawahara A., Nishina H., and Aoki J.: J. Biol. Chem. 286(51) 43972-43983 (2011) PMID 21971049 | |
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LPA3, a unique G protein-coupled receptor for lysophosphatidic acid; Hama K., and Aoki J.: Prog. Lipid Res. 49(4) 335-342 (2010) PMID 20230855 | |
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Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation; Williams, J. R., Khandoga, A. L., Goyal, P., Fells, J. I., Perygin, D. H., Siess, W., Parrill, A. L., Tigyi, G.; Fujiwara, Y.; J. Biol. Chem., 284(25), (2009) 17304-17319 PMID:19366702 | |
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In vivo imaging of zebrafish digestive organ function using multiple quenched fluorescent reporters; Hama K., Provost E., Baranowski TC., Rubinstein AL., Anderson JL., Leach SD. and Farber SA.: Am. J. Physiol.-Gastrointestinal and Liver Physiology 296(2) 445-453 (2009) PMID 19056761 | |
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A unique bioactive phospholipid Cyclic phosphatidic acid; Fujiwara, Y.; Biochim. Biophys. Acta, 1781(9), 519-524 (2008) PMID:18554524 | |
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Expression of a novel 90-kDa protein, Lsd90, involved in the metabolism of very long-chain fatty acid-containing phospholipids in a mitosis-defective fission yeast mutant; Yokoyama, K., Nakagawa, M., Satoh, M., Saitoh, S., Dohmae, N., Harada, A., Satoh, N., Karasawa, K., Takio, K., Yanagida, M., Inoue, K.: J. Biochem. 143(3) 369-375 (2008) PMID 18079165 | |
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Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors; Valentine, W.J., Fells, J.I., Perygin, D.H., Mujahid, S., Yokoyama, K., Fujiwara, Y., Tsukahara, R., Van Brocklyn, J.R., Parrill, A.L., and Tigyi, G.: J. Biol. Chem. 283(18) 12175-12187 (2008) PMID 18316373 | |
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Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice; Hama K., Aoki J., Inoue A., Endo T., Amano T., Motoki R., Kanai M., Ye X., Chun J., Matsuki N., Suzuki H., Shibasaki M. and Arai H.: Biol Reprod 77(6) 954-959 (2007) PMID 17823089 |
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Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration; Long, J.S., Yokoyama, K., Tigyi, G., Pyne, N.J. and Pyne, S.: Biochem J. 394(2) 495-500 (2006) PMID 16356167 | |
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Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus; Hama K., Aoki J., Bandoh K., Inoue A., Endo T., Amano T., Suzuki H. and Arai H.: Life Sci. 79(18) 1736-1740 (2006) PMID 16815476 | |
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Red blood cells highly express type I platelet-activating factor-acetylhydrolase (PAF-AH) which consists of the alpha1/alpha2 complex; Karasawa, K., Shirakura, M., Harada, A., Satoh, N., Yokoyama, K., Setaka, M. and Inoue, K.: J Biochem (Tokyo). 138(4) 509-517 (2005) PMID: 16272147 | |
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LPA3-mediated lysophosphatidic acid signaling in implantation and embryo spacing; Ye X.*, Hama K.*, Contos JA., Anlinker B., Inoue A., Skinner MK., Suzuki H., Amano T., Kennedy G., Arai H., Aoki J. and Chun J. (*co-first author): Nature 435(7038):104-108 (2005) PMID 15875025 | |
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Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level; Yue, J., Yokoyama, K., Balazs, L., Baker, D.L., Smalley, D., Pilquil, C., Brindley, D.N. and Tigyi, G.: Cell Signal. 16(3) 385-399 (2004) PMID 14687668 | |
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Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1; Hama K., Aoki J., Fukaya M.,Kishi Y.,Sakai T.,Suzuki R.,Ohta H., Yamori T., Watanabe M., Chun J. and Arai H.: J. Biol. Chem. 279(17) 17634-17639 (2004) PMID 14744855 | |
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Regulation of activities of cytidine 5'-diphospho-choline:1-O-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase, an enzyme responsible for de novo synthesis of platele-activating factor, by membrane phospholipids; Satoh, N., Harada, A., Yokoyama, K., Karasawa, K., Inoue, K. and Setaka, M.: J. Health Sci. 49(1) 13-21 (2003) | |
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Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors; Virag, T., Elrod, D.B., Liliom, K., Sardar, V.M., Parrill, A.L., Yokoyama, K., Durgam, G., Deng, W., Miller, D.D. and Tigyi, G.: Mol. Pharmacol. 63(5) 1032-1042 (2003) PMID: 12695531 | |
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Stereochemical properties of lysophosphatidic acid signaling and metabolism; Yokoyama, K., Baker, D., Virag, T., Liliom, K., Byun, H.-S., Tigyi, G. and Bittman, R.: Biochim. Biophys. Acta 1582(1-3) 295-308 (2002) PMID: 12069841 | |
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Molecular basis for lysophosphatidic acid receptor antagonist selectivity; Sardar, V.M., Bautista, D.L., Fischer, D.J., Yokoyama, K., Nusser, N., Virag, T., Wang, D., Baker, D.L., Tigyi, G. and Parrill, A.L.: Biochim. Biophys. Acta 1582(1-3) 309-317 (2002) PMID: 12069842 | |
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Lysophosphatidic acid （LPA） receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors; Hama K., Bandoh K., Kakehi Y., Aoki J. and Arai H.: FEBS Lett. 523(1-3) 187-192 (2002) PMID 12123830 | |
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37.
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Very-long-chain fatty acid-containing phospholipids accumulate in fatty acid synthase temperature-sensitive mutant strains of the fission yeast Schizosaccharomyces pombe fas2/lsd1; Yokoyama, K., Saitoh, S., Ishida, M., Yamakawa, Y., Nakamura, K., Inoue, K., Taguchi, R. Tokumura, A., Nishijima, M., Yanagida, M. and Setaka, M.: Biochim. Biophys. Acta 1532(3), 223-233 (2001) PMID: 11470243 | |
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38.
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Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors; Fischer, D.J., Nusser, N., Virag, T., Yokoyama, K., Wang, D., Baker, D.L., Bautista, D., Parrill, A.L. and Tigyi, G.: Mol. Pharmacol. 60(4), 776-784 (2001) PMID: 11562440 | |
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Simultaneous separation of lysophospholipids from the total lipid fraction of crude biological samples using two-dimensional thin-layer chromatography; Yokoyama, K., Shimizu, F. and Setaka, M.: J. Lipid Res. 41(1) 142-147 (2000) PMID: 10627512 | |
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40.
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Transfection of the plasma-type platelet-activating factor acetylhydrolase gene attenuates glutamate-induced apoptosis in cultured rat cortical neurons; Hirashima, Y., Ueno, H., Karasawa, K., Yokoyama, K., Setaka, M. and Takaku, A.: Brain Res. 885(1) 128-132 (2000) PMID: 11121539 | |
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41. |
The Escherichia coli pldC gene encoding lysophospholipase L1 is identical to the apeA and tesA genes encoding protease I and thioesterase I, respectively; Karasawa, K., Yokoyama, K., Setaka, M. and Nojima, S.: J. Biochem. 126(2) 445-448 (1999) PMID: 10423542 | |
42. |
Deficient platelet-activating factor and related enzymes in hemimegalencephaly; Hirashima, Y., Endo, S., Karasawa, K., Sato, N., Yokoyama, K., Kurimoto, M., Ikeda, H., Setaka, M., and Takaku, A. Childs Nerv. Syst., 15(2-3), 98-101 (1999). PMID: 10230665 | |
43. |
Changes in composition of newly synthesized sphingolipids of HeLa cells during the cell cycle: suppression of sphingomyelin and higher-glycosphingolipids synthesis and accumulation of ceramide and glucosylceramide in mitotic cells; Yokoyama, K., Suzuki, M., Kawashima, I., Karasawa, K., Nojima, S., Enomoto, T., Tai T., Suzuki, A., and Setaka, M. Eur. J. Biochem., 249, 450-455 (1997). PMID: 9370353 | |
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44.
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Cloning, expression and characterization of plasma platelet-activating factor-acetylhydrolase from Guinea Pig; Karasawa, K., Kuge, O., Kawasaki, K., Nishijima, M., Nakano, Y., Tomita, M., Yokoyama, K., Setaka, M. and Nojima, S. J. Biochem., 120, 838-844 (1996). PMID: 8947850 | |
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Clear differences in ceramide metabolism between glycosphingolipids and sphingomyelin in a human promyelocytic leukemia cell line HL-60 stimulated by a differentiation inducer; Yokoyama, K. Nojiri, H. Suzuki, M., Setaka, M., Suzuki, A. and Nojima, A. FEBS Lett., 368, 477-480 (1995). PMID: 7635202 |
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Phospholipid degradation in rat calcium ionophore-activated platelets is catalyzed mainlyby two discrete secretory phospholipase As; Yokoyama, K., Kudo, I., and Inoue, K. J. Biochem., 117, 1280-1287 (1995). PMID: 7490272 | |
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A possible role for extracellular bicarbonate in U-46619-induced rat platelet aggregation; Yokoyama K.,, Kudo, I., Nakamura, H. and Inoue, K. Thromb. Res., 74, 369-376 (1994). PMID: 8085238 | |
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著書リスト・その他 | |
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1.
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Lipidomics of peroxisomal disorders, in Peroxisomes: Biogenesis, Function, and Role in Human Disease, Springer, Editors: Imanaka T., Shimozawa N. (ISBN 978-981-15-1168-4) Hama K, Fujiwara Y, Yokoyama K., (2019) | |
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脂肪酸関連代謝物 グリセロ脂質など、発色その他の分析法、横山 和明、試料分析講座 脂質分析、pp45-53、丸善出版、(2011) | |
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医薬品と製剤材料の安定性、横山 和明、基礎から学ぶ製剤化のサイエンス 増補版、山本 恵司監修、pp.96-121、エルゼビアジャパン、(2011) | |
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4.
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医薬品と製剤材料の安定性、横山 和明、基礎から学ぶ製剤化のサイエンス、山本 恵司監修、pp.95-121、エルゼビアジャパン、(2008) | |
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