Laboratory of Molecular Pharmaceutics
Publication List (Journals)
1. Expression of a novel 90-kDa protein, Lsd90, involved in the metabolism of very long-chain fatty acid-containing phospholipids in a mitosis-defective fission yeast mutant; Yokoyama, K., Nakagawa, M., Satoh, M., Saitoh, S., Dohmae, N., Harada, A., Satoh, N., Karasawa, K., Takio, K., Yanagida, M., Inoue, K.: J. Biochem. 143(3) 369-375 (2008) PMID 18079165
2. Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors; Valentine, W.J., Fells, J.I., Perygin, D.H., Mujahid, S., Yokoyama, K., Fujiwara, Y., Tsukahara, R., Van Brocklyn, J.R., Parrill, A.L., and Tigyi, G.: J. Biol. Chem. 283(18) 12175-12187 (2008) PMID 18316373
3. Clinical aspects of plasma platelet-activating factor-acetylhydrolase; Karasawa, K.: Biochim. Biophys. Acta. 1761(11) 1359-1372 (2006) REVIEW PMID 17049457
4. Adenovirus-mediated gene transfer and lipoprotein-mediated protein delivery of plasma PAF-AH ameliorates proteinuria in rat model of glomerulosclerosis; Iso-O, N., Noto, H., Hara, M., Togo, M., Karasawa, K., Ohashi, N., Noiri, E., Hashimoto, Y., Kadowaki, T., Kimura, S., Watanabe, T. and Tsukamoto, K.: Mol. Ther. 13(1) 118-126 (2006) PMID 16213192
5. Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration; Long, J.S., Yokoyama, K., Tigyi, G., Pyne, N.J. and Pyne, S.: Biochem J. 394(2) 495-500 (2006) PMID 16356167
6. Red blood cells highly express type I platelet-activating factor-acetylhydrolase (PAF-AH) which consists of the alpha1/alpha2 complex; Karasawa, K., Shirakura, M., Harada, A., Satoh, N., Yokoyama, K., Setaka, M. and Inoue, K.: J Biochem (Tokyo). 138(4) 509-517 (2005) PMID: 16272147
7. Local expression of platelet-activating factor-acetylhydrolase reduces accumulation of oxidized lipoproteins and inhibits inflammation, shear stress-induced thrombosis, and neointima formation in balloon-injured carotid arteries in nonhyperlipidemic rabbits; ¥ Arakawa, H., Qian, J.Y., Baatar, D., Karasawa, K., Asada, Y., Sasaguri, Y., Miller, E.R., Witztum, J.L. and Ueno, H.: Circulation 111(24) 3302-3309 (2005) PMID 15956136
8. Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level; Yue, J., Yokoyama, K., Balazs, L., Baker, D.L., Smalley, D., Pilquil, C., Brindley, D.N. and Tigyi, G.: Cell Signal. 16(3) 385-399 (2004) PMID 14687668
9. Plasma platelet activating factor-acetylhydrolase (PAF-AH); Karasawa, K., Harada, A., Satoh, N., Inoue, K. and Setaka, M.: Prog. Lipid Res. 42(2) 93-114 (2003) PMID: 12547653
10. Regulation of activities of cytidine 5'-diphospho-choline:1-O-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase, an enzyme responsible for de novo synthesis of platele-activating factor, by membrane phospholipids; Satoh, N., Harada, A., Yokoyama, K., Karasawa, K., Inoue, K. and Setaka, M.: J. Health Sci. 49(1) 13-21 (2003)
11. Human plasma platelet-activating factor acetylhydrolase binds to all the murine lipoproteins, conferring protection against oxidative stress; Noto, H., Hara, M., Karasawa, K., Iso-O, N., Satoh, H., Togo, M., Hashimoto, Y., Yamada, Y., Kosaka, T., Kawamura, M., Kimura, S. and Tsukamoto, K.: Arterioscler. Thromb. Vasc. Biol. 23(5) 829-35 (2003) PMID: 12649088
12. Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors; Virag, T., Elrod, D.B., Liliom, K., Sardar, V.M., Parrill, A.L., Yokoyama, K., Durgam, G., Deng, W., Miller, D.D. and Tigyi, G.: Mol. Pharmacol. 63(5) 1032-1042 (2003) PMID: 12695531
13. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production; Umezu-Goto. M., Kishi, Y., Taira, A., Hama, K., Dohmae, N., Takio, K., Yamori, T., Mills, G.B., Inoue, K., Aoki, J. and Arai, H.: J. Cell Biol. 158(2) 227-233 (2002) PMID: 12119361
14. Stereochemical properties of lysophosphatidic acid signaling and metabolism; Yokoyama, K., Baker, D., Virag, T., Liliom, K., Byun, H.-S., Tigyi, G. and Bittman, R.: Biochim. Biophys. Acta 1582(1-3) 295-308 (2002) PMID: 12069841
15. Molecular basis for lysophosphatidic acid receptor antagonist selectivity; Sardar, V.M., Bautista, D.L., Fischer, D.J., Yokoyama, K., Nusser, N., Virag, T., Wang, D., Baker, D.L., Tigyi, G. and Parrill, A.L.: Biochim. Biophys. Acta 1582(1-3) 309-317 (2002) PMID: 12069842
16. Identification and functional characterization of nadrin variants, a novel family of GTPase activating protein for rho GTPases; Furuta, B., Harada, A., Kobayashi, Y., Takeuchi, K., Kobayashi, T. and Umeda, M.: J. Neurochem. 82(5) 1018-1028 (2002) PMID: 12358749
17. Very-long-chain fatty acid-containing phospholipids accumulate in fatty acid synthase temperature-sensitive mutant strains of the fission yeast Schizosaccharomyces pombe fas2/lsd1; Yokoyama, K., Saitoh, S., Ishida, M., Yamakawa, Y., Nakamura, K., Inoue, K., Taguchi, R. Tokumura, A., Nishijima, M., Yanagida, M. and Setaka, M.: Biochim. Biophys. Acta 1532(3), 223-233 (2001) PMID: 11470243
18. Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis; Shibata, N., Arita, M., Misaki, Y., Dohmae, N., Takio, K., Ono, T., Inoue, K. and Arai, H.: Proc. Natl. Acad. Sci. USA. 98(5) 2244-2249 (2001) PMID: 11226224
19. Alpha-tocopherol transfer protein is important for the normal development of placental labyrinthine trophoblasts in mice; Jishage, K., Arita, M., Igarashi, K., Iwata, T., Watanabe, M., Ogawa, M., Ueda, O., Kamada, N., Inoue, K., Arai, H. and Suzuki, H.: J. Biol. Chem. 276(3) 1669-1672 (2001) PMID: 11076932
20. Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme; Min, J.H., Wilder, C., Aoki, J., Arai, H., Inoue, K. Paul, L., and Gelb, M.H.: Biochemistry 40(15) 4539-4549 (2001) PMID: 11294621
21. Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors; Fischer, D.J., Nusser, N., Virag, T., Yokoyama, K., Wang, D., Baker, D.L., Bautista, D., Parrill, A.L. and Tigyi, G.: Mol. Pharmacol. 60(4), 776-784 (2001) PMID: 11562440
22. Simultaneous separation of lysophospholipids from the total lipid fraction of crude biological samples using two-dimensional thin-layer chromatography; Yokoyama, K., Shimizu, F. and Setaka, M.: J. Lipid Res. 41(1) 142-147 (2000) PMID: 10627512
23. Transfection of the plasma-type platelet-activating factor acetylhydrolase gene attenuates glutamate-induced apoptosis in cultured rat cortical neurons; Hirashima, Y., Ueno, H., Karasawa, K., Yokoyama, K., Setaka, M. and Takaku, A.: Brain Res. 885(1) 128-132 (2000) PMID: 11121539
24. The functional implications of the dimerization of the catalytic subunits of the mammalian brain platelet-activating factor acetylhydrolase (Ib); McMullen, T.W., Li, J., Sheffield, P.J., Aoki, J., Martin, T.W., Arai, H., Inoue, K. and Derewenda, Z.S.: Protein Eng. 13(12):865-871 (2000) PMID: 11239086
25. Platelet-activating factor (PAF)-dependent transacetylase and its relationship with PAF acetylhydrolases; Bae, K., Longobardi, L., Karasawa, K., Malone, B., Inoue, T., Aoki, J., Arai, H., Inoue, K. and Lee, T.: J. Biol. Chem. 275(35) 26704-26709 (2000) PMID: 10867005
26. Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis; Harada, A., Furuta, B., Takeuchi, K., Itakura, M., Takahashi, M. and Umeda, M.: J. Biol. Chem. 275(47) 36885-36891 (2000) PMID: 10967100
27. The Escherichia coli pldC gene encoding lysophospholipase L1 is identical to the apeA and tesA genes encoding protease I and thioesterase I, respectively; Karasawa, K., Yokyama, K., Setaka, M. and Nojima, S.: J. Biochem. 126(2) 445-448 (1999) PMID: 10423542
28. Purification and characterization from rat kidney membranes of a novel platelet-activating factor (PAF)-dependent transacetylase that catalyzes the hydrolysis of PAF, formation of PAF analogs, and C2-ceramide; Karasawa, K., Qiu, X and Lee, T. J. Biol. Chem. 274(13) 8655-8661 (1999). PMID: 10085103

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