帝京大学薬学部 | 研究室ページ | English | |
製剤学研究室 | ||
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論文リスト | ||
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Involvement of proton-coupled organic cation antiporter in varenicline transport at blood-brain barrier of rats and in human brain capillary endothelial cells.; Kurosawa T, Higuchi K, Okura T, Kobayashi K, Kusuhara H, Deguchi Y; J. Pharm. Sci., in press (2017) | |
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Activation of PPARγ at an early stage of differentiation enhances adipocyte differentiation of MEFs derived from Type II diabetic TSOD mice and alters lipid droplet morphology.; Ishibashi K, Takeda Y, Nakatani E, Sugawara K, Imai R, Sekiguchi M, Takahama R, Ohkura N, Atsumi G; Biol. Pharm. Bull. in press (2017) | |
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Histamine elimination from the cerebrospinal fluid across the blood-cerebrospinal fluid barrier: involvement of plasma membrane monoamine transporter (PMAT/SLC29A4).; Usui T, Nakazawa A, Okura T, Deguchi Y, Akanuma SI, Kubo Y, Hosoya KI; J Neurochem. 139(3), 408-418 (2016) | |
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Cocktail-dosing microdialysis study to simultaneously assess delivery of multiple organic-cationic drugs to the brain.; Kitamura A, Okura T, Higuchi K, Deguchi Y; J. Pharm. Sci. 105(2), 935-940 (2016) | |
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麻薬性鎮痛薬の中枢効果を制御する血液脳関門輸送機構.; 黄倉 崇,樋口 慧,出口芳春; 薬学雑誌135(5), 697-702 (2015) | |
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Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model.; Higuchi K, Kitamura A, Okura T, Deguchi Y; Drug Metab Pharmacokinet., 30(2), 182-187 (2015) | |
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Transport characteristics of tramadol in the blood-brain barrier.; Kitamura A, Higuchi K, Okura T, Deguchi Y; J. Pharm. Sci., 103(10), 3335-3341 (2014) | |
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Proton-coupled organic cation antiporter-mediated uptake of apomorphine enantiomers in human brain capillary endothelial cell line hCMEC/D3.; Okura T, Higuchi K, Kitamura A, Deguchi Y; Biol Pharm Bull., 37 (2), 286-291 (2014) | |
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Functional expression of organic cation/carnitine transporter 2 (OCTN2/SLC22A5) in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model.; Okura T, Kato S, Deguchi Y; Drug Metab Pharmacokinet., 29 (1), 69-74 (2014) | |
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Endothelin-1 receptors in rat tissues: characterization by bosentan, ambrisentan and CI-1020.; Yokoyama Y, Osano A, Hayashi H, Itoh K, Okura T, Deguchi Y, Ito Y, Yamada S; Biol. Pharm. Bull., 37 (3), 461-465 (2014) | |
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Bladder endothelin-1 receptor binding of bosentan and ambrisentan.; Osano A, Yokoyama Y, Hayashi H, Itoh K, Okura T, Deguchi Y, Ito Y, Yamada S; J Pharmacol Sci., 124(1), 86-91 (2014) | |
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Muscarinic receptor binding of the novel radioligand, [(3)H]imidafenacin in the human bladder and parotid gland.; Yoshida A, Kuraoka S, Ito Y, Okura T, Deguchi Y, Otsuka A, Ozono S, Takeda M, Masuyama K, Araki I, Yamada S; J. Pharmcol. Sci., 124 (1), 40-46 (2014) | |
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Muscarinic receptor binding of the novel radioligand, [3h]imidafenacin in the human bladder and parotid gland.; Yoshida A, Kuraoka S, Ito Y, Okura T, Deguchi Y, Otsuka A, Ozono S, Takeda M, Masuyama K, Araki I, Yamada S; J Pharmacol Sci. 124(1):40-46 (2014) | |
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Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model.; Shimomura K, Okura T, Kato S, Couraud PO, Schermann JM, Terasaki T, Deguchi Y; Fluid Barrier CNS, 10:8, (2013). | |
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Suppression of murine collagen-induced arthritis by vaccination of synovial vascular endothelial cells.; Sawaguchi Y, Hirata K, Suzuki R, Utoguchi N, Maruyama K; Life Sci.; 92(23), 1125-1130 (2013) | |
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Suppression of murine collagen-induced arthritis by vaccination of synovial vascular endothelial cells.; Sawaguchi Y, Hirata K, Suzuki R, Utoguchi N, Maruyama K; Life Sci.; 92(23), 1125-1130 (2013) | |
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Prophylactic immunization with Bubble liposomes and ultrasound-treated dendritic cells provided a four-fold decrease in the frequency of melanoma lung metastasis.; Oda Y, Suzuki R, Otake S, Nishiie N, Hirata K, Koshima R, Nomura T, Utoguchi N, Kudo N, Tachibana K, Maruyama K.; J Control Release. 160(2):362-366 (2012) | |
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Associations between plasma PAI-1 concentrations and its expressions in various organs in obese model mice.; Ohkura N, Shirakura M, Nakatani E, Oishi K, Atsumi G; Thrombosis research 130: e301-4 (2012) | |
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Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo.; Muhammad Waqas Sadiq, Annika Borgs, Takashi Okura, Keita Shimomura, Sayaka Kato, Yoshiharu Deguchi, Britt Jansson1, Sven Bjorkman, Tetsuya Terasaki, Margareta Hammarlund-Udenaes; J. Pharm. Sci., 100 (9), 3912 - 3923 (2011) | |
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Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers.; Okura T, Kato S, Takano Y, Sato T, Yamashita A, Morimoto R, Ohtsuki S, Terasaki T, Deguchi Y; J. Pharm. Sci. 100 (9), 3924 - 3938 (2011) | |
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Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure.; Suzuki R, Namai E, Oda Y, Nishiie N, Otake S, Koshima R, Hirata K, Taira Y, Utoguchi N, Negishi Y, Nakagawa S, Maruyama K.; J Control Release.; 142(2):245-250 (2010) | |
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Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier transport and antinociceptive effect.; Nakazawa Y, Okura T, Shimomura K, Terasaki T, Deguchi Y; J. Pharm. Sci., 99(1), 467-474 (2010). | |
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Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells.; Okura T, Ibe M, Umegaki K, Shinozuka K, Yamada S; Biol Pharm Bull. 33(2):255-259 (2010) | |
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Effects of repeated morphine treatment on the antinociceptive effects, intestinal absorption, and efflux from intestinal epithelial cells of morphine.; Okura T, Ozawa T, Ibe M, Taki Y, Kimura M, Kagawa Y, Kato Y, Yamada S; Biol Pharm Bull. 32(9):1571-1575 (2009) | |
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Effects of quinidine on antinociception and pharmacokinetics of morphine in rats.; Okura T, Morita Y, Ito Y, Kagawa Y, Yamada S; J Pharm Pharmacol. 61(5), 593-597 (2009) | |
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Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone.; Okura T, Hattori A, Takano Y, Sato T, Hammarlund-Udenaes M, Terasaki T, Deguchi Y; Drug Metab Dispos.; 36(10), 2005-2013 (2008) | |
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Enhancement by grapefruit juice of morphine antinociception.; Okura T, Ozawa T, Ito Y, Kimura M, Kagawa Y, Yamada S; Biol Pharm Bull.; 31(12), 2338-2341 (2008) | |
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Blood-brain barrier transport of pramipexole, a dopamine D2 agonist.; Okura T, Ito R, Ishiguro N, Tamai I, Deguchi Y; Life Sci.; 80(17), 1564-1571 (2007) | |
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Prediction of alpha1-adrenoceptor occupancy in the human prostate from plasma concentrations of silodosin, tamsulosin and terazosin to treat urinary obstruction in benign prostatic hyperplasia.; Yamada S, Kato Y, Okura T, Kagawa Y, Kawabe K; Biol Pharm Bull.; 30(7), 1237-1241 (2007) | |
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Different effects of morphine and morphine-6beta-glucuronide on formalin-evoked spinal glutamate release in conscious and freely moving rats.; Okura T, Komiyama N, Morita Y, Kimura M, Yamada S; Neurosci Lett.; 415(2), 169-173 (2007) | |
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Comparative measurement of spinal CSF microdialysate concentrations and concomitant antinociception of morphine and morphine-6beta-glucuronide in rats.; Okura T, Komiyama N, Morita Y, Kimura M, Deguchi Y, Yamada S; Life Sci.; 80(14), 1319-1326 (2007) | |
著書リスト・その他 | ||
1.
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薬物分布実験法 脳関門; 黄倉崇・出口芳春; 薬剤学実験 必携マニュアル; 南江堂; 124-137 (2014) | |
2.
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褐色脂肪細胞から肝臓へのおくりもの; 中谷絵理子; ファルマシア; 51, 8 (2014) | |
3.
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トロイの木馬抗体を用いた中枢作用型タンパク質・遺伝子医薬開発の最前線; 黄倉崇・出口芳春; 細胞工学; 秀潤社; 962-964 (2013) | |
4.
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Pharmacokinetic and pharmacodynamic interaction of functional foods with medicines.; Yamada S, Taki Y, Misaka S, Okura T DeguchiY , Umegaki K, Watanabe H,Watanabe Y Skinner M;Bioactives in Fruit: Health benefits and functional foods, First edition; Wiley-Blackwell; 59-80 (2013) | |
5.
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分布; 黄倉崇・出口芳春; コンパス生物薬剤学(改訂第2版); 南江堂; 51-67 (2012) | |
6.
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カチオン性薬物の血液脳関門輸送機構の解明をめざして 麻薬性鎮痛薬の受容体研究から血液脳関門研究; 出口芳春; 薬剤学, 69, 426-429 (2009) | |
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